Ionis Pharmaceuticals annual free cash flow
2008
2009
2010
2011
2012
2013
2014
2015
2016
2017
2018
2019
2020
2021
2022
2023
2024
2025
Ionis Pharmaceuticals Free Cash Flow (FCF) History (IONS)
Ionis Pharmaceuticals reported −$320.0M in free cash flow for fiscal 2025, an increase of $226.2M from the previous fiscal year, with a free cash flow margin of −33.91%.
View full Ionis Pharmaceuticals company overviewIonis Pharmaceuticals free cash flow by year
| Fiscal year | Period ended | Free cash flow | Change | Growth | FCF margin |
|---|---|---|---|---|---|
| 2025 | 2025-12-31 | −$320.0M | $226.2M | — | −33.91% |
| 2024 | 2024-12-31 | −$546.2M | −$214.9M | — | −77.46% |
| 2023 | 2023-12-31 | −$331.3M | −$41.2M | — | −42.06% |
| 2022 | 2022-12-31 | −$290.1M | −$308.9M | — | −49.39% |
| 2021 | 2021-12-31 | $18.8M | $18.1M | +2340.93% | +2.33% |
| 2020 | 2020-12-31 | $772,000 | −$313.9M | −99.75% | +0.11% |
| 2019 | 2019-12-31 | $314.7M | −$274.6M | −46.59% | +28.04% |
| 2018 | 2018-12-31 | $589.3M | $449.9M | +322.78% | +98.27% |
| 2017 | 2017-12-31 | $139.4M | $258.6M | — | +27.11% |
| 2016 | 2016-12-31 | −$119.2M | −$132.6M | — | −31.98% |
| 2015 | 2015-12-31 | $13.4M | $14.7M | — | +4.73% |
| 2014 | 2014-12-31 | −$1.2M | −$63.2M | — | −0.58% |
| 2013 | 2013-12-31 | $61.9M | $61.5M | +15502.27% | +42.06% |
| 2012 | 2012-12-31 | $397,000 | $125.4M | — | +0.39% |
| 2011 | 2011-12-31 | −$125.0M | −$48.2M | — | −126.16% |
| 2010 | 2010-12-31 | −$76.8M | $45.0M | — | −70.83% |
| 2009 | 2009-12-31 | −$121.9M | −$320.2M | — | −100.21% |
| 2008 | 2008-12-31 | $198.4M | — | — | +185.06% |
Ionis Pharmaceuticals quarterly free cash flow
Q3.09
Q1.10
Q2.10
Q3.10
Q4.10
Q1.11
Q2.11
Q3.11
Q4.11
Q1.12
Q2.12
Q3.12
Q4.12
Q1.13
Q2.13
Q3.13
Q4.13
Q1.14
Q2.14
Q3.14
Q4.14
Q1.15
Q2.15
Q3.15
Q4.15
Q1.16
Q2.16
Q3.16
Q4.16
Q1.17
Q2.17
Q3.17
Q4.17
Q1.18
Q2.18
Q3.18
Q4.18
Q1.19
Q2.19
Q3.19
Q4.19
Q1.20
Q2.20
Q3.20
Q4.20
Q1.21
Q2.21
Q3.21
Q4.21
Q1.22
Q2.22
Q3.22
Q4.22
Q1.23
Q2.23
Q3.23
Q4.23
Q1.24
Q2.24
Q3.24
Q4.24
Q1.25
Q2.25
Q3.25
Q4.25
Q1.26
Q2.26
| Fiscal quarter | Period ended | Free cash flow | Change | YoY growth | FCF margin |
|---|---|---|---|---|---|
| Q2 2026 | 2026-06-30 | $549.5M | $410.4M | +295.19% | +205.06% |
| Q1 2026 | 2026-03-31 | −$814.6M | −$651.2M | — | −331.01% |
| Q4 2025 | 2025-12-31 | −$159.0M | −$17.4M | — | −78.20% |
| Q3 2025 | 2025-09-30 | −$136.7M | −$12.7M | — | −87.23% |
| Q2 2025 | 2025-06-30 | $139.0M | $265.1M | — | +30.76% |
| Q1 2025 | 2025-03-31 | −$163.4M | −$8.9M | — | −124.12% |
| Q4 2024 | 2024-12-31 | −$141.6M | −$173.7M | — | −62.51% |
| Q3 2024 | 2024-09-30 | −$124.0M | −$12.9M | — | −92.70% |
| Q2 2024 | 2024-06-30 | −$126.1M | −$16.7M | — | −55.99% |
| Q1 2024 | 2024-03-31 | −$154.4M | −$10.0M | — | −129.23% |
| Q4 2023 | 2023-12-31 | $32.0M | $236.4M | — | +9.88% |
| Q3 2023 | 2023-09-30 | −$111.2M | −$81.2M | — | −77.09% |
| Q2 2023 | 2023-06-30 | −$109.4M | −$87.9M | — | −58.05% |
| Q1 2023 | 2023-03-31 | −$144.5M | −$110.1M | — | −110.68% |
| Q4 2022 | 2022-12-31 | −$204.3M | −$405.5M | — | −134.53% |
| Q3 2022 | 2022-09-30 | −$30.0M | $28.9M | — | −18.76% |
| Q2 2022 | 2022-06-30 | −$21.4M | $45.6M | — | −16.02% |
| Q1 2022 | 2022-03-31 | −$34.4M | $22.1M | — | −24.21% |
| Q4 2021 | 2021-12-31 | $201.2M | $108.4M | +116.73% | +45.72% |
| Q3 2021 | 2021-09-30 | −$58.9M | −$36.8M | — | −44.25% |
| Q2 2021 | 2021-06-30 | −$67.0M | −$13.7M | — | −53.29% |
| Q1 2021 | 2021-03-31 | −$56.4M | −$39.8M | — | −50.56% |
| Q4 2020 | 2020-12-31 | $92.8M | −$177.2M | −65.63% | +31.98% |
| Q3 2020 | 2020-09-30 | −$22.1M | $6.6M | — | −13.79% |
| Q2 2020 | 2020-06-30 | −$53.3M | −$22.2M | — | −36.63% |
| Q1 2020 | 2020-03-31 | −$16.7M | −$121.1M | — | −12.50% |
| Q4 2019 | 2019-12-31 | $270.1M | $156.0M | +136.66% | +54.71% |
| Q3 2019 | 2019-09-30 | −$28.7M | $542,000 | — | −17.10% |
| Q2 2019 | 2019-06-30 | −$31.1M | −$524.7M | — | −19.00% |
| Q1 2019 | 2019-03-31 | $104.5M | $93.7M | +865.40% | +35.15% |
| Q4 2018 | 2018-12-31 | $114.1M | $102.0M | +840.12% | +59.40% |
| Q3 2018 | 2018-09-30 | −$29.2M | −$40.9M | — | −20.12% |
| Q2 2018 | 2018-06-30 | $493.6M | $497.5M | — | +419.21% |
| Q1 2018 | 2018-03-31 | $10.8M | −$108.6M | −90.94% | +7.49% |
| Q4 2017 | 2017-12-31 | $12.1M | $41.8M | — | +7.23% |
| Q3 2017 | 2017-09-30 | $11.7M | −$11.6M | −49.77% | +9.86% |
| Q2 2017 | 2017-06-30 | −$3.9M | $32.6M | — | −3.43% |
| Q1 2017 | 2017-03-31 | $119.4M | $195.8M | — | +103.13% |
| Q4 2016 | 2016-12-31 | −$29.6M | $10.3M | — | −18.48% |
| Q3 2016 | 2016-09-30 | $23.2M | −$11.6M | −33.38% | +20.95% |
| Q2 2016 | 2016-06-30 | −$36.4M | −$98.6M | — | −94.67% |
| Q1 2016 | 2016-03-31 | −$76.4M | −$32.7M | — | −207.18% |
| Q4 2015 | 2015-12-31 | −$39.9M | −$107.0M | — | −77.34% |
| Q3 2015 | 2015-09-30 | $34.9M | $33.8M | +3144.37% | +71.00% |
| Q2 2015 | 2015-06-30 | $62.1M | $97.9M | — | +51.60% |
| Q1 2015 | 2015-03-31 | −$43.7M | −$10.0M | — | −69.83% |
| Q4 2014 | 2014-12-31 | $67.1M | $82.1M | — | +79.11% |
| Q3 2014 | 2014-09-30 | $1.1M | −$64.2M | −98.35% | +2.44% |
| Q2 2014 | 2014-06-30 | −$35.7M | −$58.1M | — | −62.57% |
| Q1 2014 | 2014-03-31 | −$33.7M | −$22.9M | — | −119.78% |
| Q4 2013 | 2013-12-31 | −$14.9M | −$50.5M | — | −35.34% |
| Q3 2013 | 2013-09-30 | $65.3M | $90.3M | — | +276.87% |
| Q2 2013 | 2013-06-30 | $22.4M | $25.7M | — | +58.73% |
| Q1 2013 | 2013-03-31 | −$10.8M | −$4.0M | — | −24.90% |
| Q4 2012 | 2012-12-31 | $35.6M | $62.5M | — | +179.08% |
| Q3 2012 | 2012-09-30 | −$25.0M | $1.1M | — | −215.84% |
| Q2 2012 | 2012-06-30 | −$3.3M | $26.3M | — | −7.03% |
| Q1 2012 | 2012-03-31 | −$6.8M | $35.6M | — | −29.37% |
| Q4 2011 | 2011-12-31 | −$26.9M | −$882,000 | — | −82.96% |
| Q3 2011 | 2011-09-30 | −$26.1M | −$3.8M | — | −126.11% |
| Q2 2011 | 2011-06-30 | −$29.6M | −$33.7M | — | −119.18% |
| Q1 2011 | 2011-03-31 | −$42.4M | −$9.7M | — | −200.59% |
| Q4 2010 | 2010-12-31 | −$26.0M | — | — | −98.41% |
| Q3 2010 | 2010-09-30 | −$22.3M | $11.4M | — | −77.82% |
| Q2 2010 | 2010-06-30 | $4.1M | — | — | +17.64% |
| Q1 2010 | 2010-03-31 | −$32.7M | — | — | −109.27% |
| Q3 2009 | 2009-09-30 | −$33.7M | — | — | −125.89% |
Ionis Pharmaceuticals free cash flow growth trends
Over the last five reported fiscal years, free cash flow declined from $772,000 to −$320.0M, a net decrease of $320.8M. Ionis Pharmaceuticals's latest reported quarter, Q2 2026, generated $549.5M in free cash flow, an increase of 295.19% year over year.
About the metric
What free cash flow means
Free cash flow is the cash a company generates from operations after capital expenditures. Positive FCF can fund dividends, buybacks, debt repayment, or reinvestment; negative FCF means capital spending exceeded operating cash flow for that period.
Calculation and source
How free cash flow is calculated
TickerStat calculates free cash flow as reported operating cash flow minus capital expenditures. FCF margin equals free cash flow divided by revenue. Fiscal periods can differ from calendar years, so the tables include exact period-end dates.
Review Ionis Pharmaceuticals source filings ↗