Ionis Pharmaceuticals annual free cash flow
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2025
Ionis Pharmaceuticals Free Cash Flow (FCF) History (IONS)
Ionis Pharmaceuticals reported −$320.0M in free cash flow for fiscal 2025, an increase of $226.2M from the previous fiscal year, with a free cash flow margin of −33.91%.
View full Ionis Pharmaceuticals company overviewIonis Pharmaceuticals free cash flow by year
| Fiscal year | Period ended | Free cash flow | Change | Growth | FCF margin |
|---|---|---|---|---|---|
| 2025 | 2025-12-31 | −$320.0M | $226.2M | — | −33.91% |
| 2024 | 2024-12-31 | −$546.2M | −$214.9M | — | −77.46% |
| 2023 | 2023-12-31 | −$331.3M | −$41.2M | — | −42.06% |
| 2022 | 2022-12-31 | −$290.1M | −$308.9M | — | −49.39% |
| 2021 | 2021-12-31 | $18.8M | $18.1M | +2340.93% | +2.33% |
| 2020 | 2020-12-31 | $772,000 | −$313.9M | −99.75% | +0.11% |
| 2019 | 2019-12-31 | $314.7M | −$274.6M | −46.59% | +28.04% |
| 2018 | 2018-12-31 | $589.3M | $449.9M | +322.78% | +98.27% |
| 2017 | 2017-12-31 | $139.4M | $258.6M | — | +27.11% |
| 2016 | 2016-12-31 | −$119.2M | −$132.6M | — | −31.98% |
| 2015 | 2015-12-31 | $13.4M | $14.7M | — | +4.73% |
| 2014 | 2014-12-31 | −$1.2M | −$63.2M | — | −0.58% |
| 2013 | 2013-12-31 | $61.9M | $61.5M | +15502.27% | +42.06% |
| 2012 | 2012-12-31 | $397,000 | $125.4M | — | +0.39% |
| 2011 | 2011-12-31 | −$125.0M | −$48.2M | — | −126.16% |
| 2010 | 2010-12-31 | −$76.8M | $45.0M | — | −70.83% |
| 2009 | 2009-12-31 | −$121.9M | −$320.2M | — | −100.21% |
| 2008 | 2008-12-31 | $198.4M | — | — | +185.06% |
Ionis Pharmaceuticals quarterly free cash flow
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Q2.26
| Fiscal quarter | Period ended | Free cash flow | Change | YoY growth | FCF margin |
|---|---|---|---|---|---|
| Q2 2026 | 2026-06-30 | $549.5M | $410.4M | +295.19% | +205.06% |
| Q1 2026 | 2026-03-31 | −$814.6M | −$651.2M | — | −331.01% |
| Q4 2025 | 2025-12-31 | −$159.0M | −$17.4M | — | −78.20% |
| Q3 2025 | 2025-09-30 | −$136.7M | −$12.7M | — | −87.23% |
| Q2 2025 | 2025-06-30 | $139.0M | $265.1M | — | +30.76% |
| Q1 2025 | 2025-03-31 | −$163.4M | −$8.9M | — | −124.12% |
| Q4 2024 | 2024-12-31 | −$141.6M | −$173.7M | — | −62.51% |
| Q3 2024 | 2024-09-30 | −$124.0M | −$12.9M | — | −92.70% |
| Q2 2024 | 2024-06-30 | −$126.1M | −$16.7M | — | −55.99% |
| Q1 2024 | 2024-03-31 | −$154.4M | −$10.0M | — | −129.23% |
| Q4 2023 | 2023-12-31 | $32.0M | $236.4M | — | +9.88% |
| Q3 2023 | 2023-09-30 | −$111.2M | −$81.2M | — | −77.09% |
| Q2 2023 | 2023-06-30 | −$109.4M | −$87.9M | — | −58.05% |
| Q1 2023 | 2023-03-31 | −$144.5M | −$110.1M | — | −110.68% |
| Q4 2022 | 2022-12-31 | −$204.3M | −$405.5M | — | −134.53% |
| Q3 2022 | 2022-09-30 | −$30.0M | $28.9M | — | −18.76% |
| Q2 2022 | 2022-06-30 | −$21.4M | $45.6M | — | −16.02% |
| Q1 2022 | 2022-03-31 | −$34.4M | $22.1M | — | −24.21% |
| Q4 2021 | 2021-12-31 | $201.2M | $108.4M | +116.73% | +45.72% |
| Q3 2021 | 2021-09-30 | −$58.9M | −$36.8M | — | −44.25% |
| Q2 2021 | 2021-06-30 | −$67.0M | −$13.7M | — | −53.29% |
| Q1 2021 | 2021-03-31 | −$56.4M | −$39.8M | — | −50.56% |
| Q4 2020 | 2020-12-31 | $92.8M | −$177.2M | −65.63% | +31.98% |
| Q3 2020 | 2020-09-30 | −$22.1M | $6.6M | — | −13.79% |
| Q2 2020 | 2020-06-30 | −$53.3M | −$22.2M | — | −36.63% |
| Q1 2020 | 2020-03-31 | −$16.7M | −$121.1M | — | −12.50% |
| Q4 2019 | 2019-12-31 | $270.1M | $156.0M | +136.66% | +54.71% |
| Q3 2019 | 2019-09-30 | −$28.7M | $542,000 | — | −17.10% |
| Q2 2019 | 2019-06-30 | −$31.1M | −$524.7M | — | −19.00% |
| Q1 2019 | 2019-03-31 | $104.5M | $93.7M | +865.40% | +35.15% |
| Q4 2018 | 2018-12-31 | $114.1M | $102.0M | +840.12% | +59.40% |
| Q3 2018 | 2018-09-30 | −$29.2M | −$40.9M | — | −20.12% |
| Q2 2018 | 2018-06-30 | $493.6M | $497.5M | — | +419.21% |
| Q1 2018 | 2018-03-31 | $10.8M | −$108.6M | −90.94% | +7.49% |
| Q4 2017 | 2017-12-31 | $12.1M | $41.8M | — | +7.23% |
| Q3 2017 | 2017-09-30 | $11.7M | −$11.6M | −49.77% | +9.86% |
| Q2 2017 | 2017-06-30 | −$3.9M | $32.6M | — | −3.43% |
| Q1 2017 | 2017-03-31 | $119.4M | $195.8M | — | +103.13% |
| Q4 2016 | 2016-12-31 | −$29.6M | $10.3M | — | −15.89% |
| Q3 2016 | 2016-09-30 | $23.2M | −$11.6M | −33.38% | +20.95% |
| Q2 2016 | 2016-06-30 | −$36.4M | −$98.6M | — | −94.67% |
| Q1 2016 | 2016-03-31 | −$76.4M | −$32.7M | — | −207.18% |
| Q4 2015 | 2015-12-31 | −$39.9M | −$107.0M | — | −77.34% |
| Q3 2015 | 2015-09-30 | $34.9M | $33.8M | +3144.37% | +71.00% |
| Q2 2015 | 2015-06-30 | $62.1M | $97.9M | — | +51.60% |
| Q1 2015 | 2015-03-31 | −$43.7M | −$10.0M | — | −69.83% |
| Q4 2014 | 2014-12-31 | $67.1M | $82.1M | — | +79.11% |
| Q3 2014 | 2014-09-30 | $1.1M | −$64.2M | −98.35% | +2.44% |
| Q2 2014 | 2014-06-30 | −$35.7M | −$58.1M | — | −62.57% |
| Q1 2014 | 2014-03-31 | −$33.7M | −$22.9M | — | −119.78% |
| Q4 2013 | 2013-12-31 | −$14.9M | −$50.5M | — | −35.34% |
| Q3 2013 | 2013-09-30 | $65.3M | $90.3M | — | +276.87% |
| Q2 2013 | 2013-06-30 | $22.4M | $25.7M | — | +58.73% |
| Q1 2013 | 2013-03-31 | −$10.8M | −$4.0M | — | −24.90% |
| Q4 2012 | 2012-12-31 | $35.6M | $62.5M | — | +179.08% |
| Q3 2012 | 2012-09-30 | −$25.0M | $1.1M | — | −215.84% |
| Q2 2012 | 2012-06-30 | −$3.3M | $26.3M | — | −7.03% |
| Q1 2012 | 2012-03-31 | −$6.8M | $35.6M | — | −29.37% |
| Q4 2011 | 2011-12-31 | −$26.9M | −$882,000 | — | −82.96% |
| Q3 2011 | 2011-09-30 | −$26.1M | −$3.8M | — | −126.11% |
| Q2 2011 | 2011-06-30 | −$29.6M | −$33.7M | — | −119.18% |
| Q1 2011 | 2011-03-31 | −$42.4M | −$9.7M | — | −200.59% |
| Q4 2010 | 2010-12-31 | −$26.0M | $7.7M | — | −98.41% |
| Q3 2010 | 2010-09-30 | −$22.3M | — | — | −77.82% |
| Q2 2010 | 2010-06-30 | $4.1M | — | — | +17.64% |
| Q1 2010 | 2010-03-31 | −$32.7M | — | — | −109.27% |
| Q3 2009 | 2009-09-30 | −$33.7M | — | — | −125.89% |
Ionis Pharmaceuticals free cash flow growth trends
Over the last five reported fiscal years, free cash flow declined from $772,000 to −$320.0M, a net decrease of $320.8M. Ionis Pharmaceuticals's latest reported quarter, Q2 2026, generated $549.5M in free cash flow, an increase of 295.19% year over year.
About the metric
What free cash flow means
Free cash flow is the cash a company generates from operations after capital expenditures. Positive FCF can fund dividends, buybacks, debt repayment, or reinvestment; negative FCF means capital spending exceeded operating cash flow for that period.
Calculation and source
How free cash flow is calculated
TickerStat calculates free cash flow as SEC-reported operating cash flow minus capital expenditures. FCF margin equals free cash flow divided by revenue. Fiscal periods can differ from calendar years, so the tables include exact period-end dates.
Review Ionis Pharmaceuticals filings at SEC.gov ↗