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Ionis Pharmaceuticals Inc (IONS)

Price$58.09Cached quote
IONSNasdaq
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Financial charts

Revenue

Net income

Free cash flow

Total cash / debt

CashTotal debt

Financial statements

18 annual periodsNewest to oldest
202520242023202220212020201920182017201620152014201320122011201020092008
Revenue$943.7M$705.1M$787.6M$587.4M$810.5M$729.3M$1.12B$599.7M$514.2M$372.8M$283.7M$214.2M$147.3M$102.0M$99.1M$108.5M$121.6M$107.2M
Gross profit$927.8M$693.9M$778.5M$573.3M$799.6M$717.3M$1.12B$597.9M$514.2M$372.8M————————
Gross margin98.31%98.41%98.84%97.60%98.66%98.36%99.61%99.70%100.00%100.00%————————
Research & development$915.6M$901.5M$899.6M$833.1M$638.2M$531.0M$461.5M$411.9M$372.5M$340.4M$319.5M$238.9M$173.7M$154.6M$153.1M$145.2M$134.6M$106.4M
Operating expenses$1.33B$1.18B$1.14B$997.6M$840.6M$901.3M$756.7M$661.0M$483.1M$392.9M$359.5M$261.9M$199.0M$171.0M$170.2M$156.8M$149.1M$120.3M
Operating income−$381.7M−$475.1M−$353.7M−$410.2M−$30.2M−$172.1M$365.9M−$61.4M$31.0M−$20.2M−$75.8M−$47.7M−$51.7M−$68.9M−$71.1M−$48.4M−$27.5M−$13.1M
Operating margin−40.45%−67.37%−44.91%−69.84%−3.72%−23.60%32.59%−10.23%6.04%−5.41%−26.70%−22.29%−35.08%−67.54%−71.76%−44.58%−22.65%−12.18%
EBITDA−$369.2M−$463.1M−$340.9M−$393.4M−$12.3M−$156.7M$380.3M−$48.8M$39.4M−$11.1M−$68.8M−$41.4M−$45.1M−$61.9M−$64.5M−$43.5M−$23.6M−$10.2M
EBITDA margin−39.13%−65.68%−43.28%−66.99%−1.52%−21.48%33.88%−8.15%7.66%−2.98%−24.24%−19.31%−30.60%−60.61%−65.10%−40.12%−19.41%−9.51%
Net income−$381.4M−$453.9M−$366.3M−$269.7M−$28.6M−$444.3M$278.1M$273.7M$346,000−$60.4M−$88.3M−$39.0M−$60.6M−$65.5M−$84.8M−$61.3M$155.1M−$18.2M
Net profit margin−40.41%−64.37%−46.50%−45.92%−3.53%−60.92%24.78%45.65%0.07%−16.20%−31.12%−18.20%−41.17%−64.16%−85.58%−56.47%127.52%−16.95%
Basic EPSper basic share-$2.38-$3.04-$2.56-$1.90-$0.20-$3.18$2.00$2.09$0.15-$0.50-$0.74-$0.33-$0.55-$0.65-$0.85-$0.62$1.58-$0.19
Diluted EPSper diluted share-$2.38-$3.04-$2.56-$1.90-$0.20-$3.18$1.90$2.07$0.15-$0.50-$0.74-$0.33-$0.55-$0.65-$0.85-$0.62$1.58-$0.19
Review official source filings ↗

Owners

Reported shareholders

Reference date Jun 30, 2026
FMR LLC · 14.87% of listed sharesCapital World Investors · 13.08% of listed sharesBlackRock, Inc. · 6.46% of listed sharesVANGUARD PORTFOLIO MANAGEMENT LLC · 4.75% of listed sharesWELLINGTON MANAGEMENT GROUP LLP · 4.62% of listed sharesVANGUARD CAPITAL MANAGEMENT LLC · 4.35% of listed sharesTWO SIGMA INVESTMENTS, LP · 3.77% of listed sharesROYAL BANK OF CANADA · 3.73% of listed sharesSTATE STREET CORP · 2.62% of listed sharesT. Rowe Price Investment Management, Inc. · 2.39% of listed sharesGEODE CAPITAL MANAGEMENT, LLC · 2.16% of listed sharesPRICE T ROWE ASSOCIATES INC /MD/ · 1.92% of listed sharesJPMORGAN CHASE & CO · 1.61% of listed sharesArtisan Partners Limited Partnership · 1.59% of listed sharesTweedy, Browne Co LLC · 1.38% of listed sharesDeep Track Capital, LP · 1.33% of listed sharesGOLDMAN SACHS GROUP INC · 1.27% of listed sharesBAKER BROS. ADVISORS LP · 1.24% of listed sharesDEERFIELD MANAGEMENT COMPANY, L.P. · 1.20% of listed sharesAMERICAN CENTURY COMPANIES INC · 1.18% of listed shares
14.87%of listed shares
FMR LLC24.63M shares · Jun 30, 2026
View holders
Top 20 reported holders of IONS
Holder% owned
FMR LLC
14.87%24.63M shares
Capital World Investors
13.08%21.67M shares
BlackRock, Inc.
6.46%10.7M shares
VANGUARD PORTFOLIO MANAGEMENT LLC
4.75%7.86M shares
WELLINGTON MANAGEMENT GROUP LLP
4.62%7.65M shares
VANGUARD CAPITAL MANAGEMENT LLC
4.35%7.21M shares
TWO SIGMA INVESTMENTS, LP
3.77%6.25M shares
ROYAL BANK OF CANADA
3.73%6.18M shares
STATE STREET CORP
2.62%4.33M shares
T. Rowe Price Investment Management, Inc.
2.39%3.96M shares
GEODE CAPITAL MANAGEMENT, LLC
2.16%3.58M shares
PRICE T ROWE ASSOCIATES INC /MD/
1.92%3.18M shares
JPMORGAN CHASE & CO
1.61%2.67M shares
Artisan Partners Limited Partnership
1.59%2.64M shares
Tweedy, Browne Co LLC
1.38%2.28M shares
Deep Track Capital, LP
1.33%2.2M shares
GOLDMAN SACHS GROUP INC
1.27%2.11M shares
BAKER BROS. ADVISORS LP
1.24%2.05M shares
DEERFIELD MANAGEMENT COMPANY, L.P.
1.20%1.98M shares
AMERICAN CENTURY COMPANIES INC
1.18%1.95M shares

Percentages use 165.64M shares of this listed class outstanding on Jun 30, 2026.

Gray completes the 100% scale. Reported positions may overlap; holders have different reporting dates.

Source: SEC Form 13F ↗Updated Sep 29, 2026 · Quarterly data

Insider buys & sells

Jul 1, 2024–Jun 30, 2026
Buys3$659.0K disclosed value
Sells (SEC code S)225$199.04M disclosed value
228 recent transactions
TransactionInsiderTypeSharesPriceValueOwned after
Jun 26, 2026Form 4 · 10b5-1Baroldi JosephEVP, Chief Business OfficerSellCommon Stock · indirect5.6K$80.16$451.7K4.7K
Jun 26, 2026Form 4 · 10b5-1O'NEIL PATRICK R.EVP CLO & General CounselSellCommon Stock3.1K$80.00$245.5K61.5K
Jun 26, 2026Form 4 · 10b5-1Schneider EugeneEVP, Chf Clinical Develop OfcrSellCommon Stock26.0K$81.05$2.11M77.1K
Jun 26, 2026Form 4 · 10b5-1Monia Brett PChief Executive OfficerSellCommon Stock50.0K$80.59$4.03M245.6K
Jun 25, 2026Form 4 · 10b5-1Monia Brett PChief Executive OfficerSellCommon Stock21.1K$78.49$1.65M245.6K
Review ownership filings at SEC.gov ↗

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