Revenue
2022
2023
2024
2025
| 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | $0 | $0 | $0 | $0 | — | — | — | — | — | — | — | — | — |
| Research & development | $25.7M | $48.2M | $29.5M | $47.3M | $44.9M | $24.7M | $44.4M | $29.8M | $16.3M | $13.2M | $7.6M | $3.7M | $1.5M |
| Operating expenses | $35.3M | $60.1M | $42.8M | $62.7M | — | — | — | — | — | — | — | — | — |
| Operating income | −$35.3M | −$60.1M | −$42.8M | −$62.7M | −$56.2M | −$36.4M | −$63.1M | −$39.7M | −$22.5M | −$18.7M | −$12.0M | −$7.3M | −$3.7M |
| EBITDA | −$35.0M | −$59.9M | −$42.5M | −$62.4M | −$56.0M | −$36.4M | −$63.0M | −$39.6M | −$22.5M | −$18.7M | −$12.0M | −$7.3M | — |
| Net income | −$33.8M | −$55.9M | −$37.5M | −$62.0M | −$57.8M | −$37.6M | −$60.8M | −$38.9M | −$22.3M | −$18.7M | −$12.1M | −$5.2M | $13.1M |
| Basic EPSper basic share | -$0.56 | -$0.94 | -$0.64 | -$1.06 | -$1.07 | -$1.11 | -$2.24 | -$1.79 | -$1.40 | -$1.65 | -$1.40 | -$2.51 | $3.49 |
| Diluted EPSper diluted share | -$0.56 | -$0.94 | -$0.64 | -$1.06 | -$1.07 | -$1.11 | -$2.24 | -$1.79 | -$1.40 | -$1.65 | -$1.40 | -$3.09 | -$17.61 |
Reported shareholders
| Holder | % owned |
|---|---|
PERCEPTIVE LIFE SCIENCES MASTER FUND LTD / EDELMAN JOSEPH / PERCEPTIVE ADVISORS LLC | ≈9.74%5.88M shares |
Knoll Capital Management, LLC | 9.08%5.48M shares |
AQR CAPITAL MANAGEMENT LLC | 6.22%3.75M shares |
KINGDON CAPITAL MANAGEMENT, L.L.C. | 4.40%2.65M shares |
VANGUARD CAPITAL MANAGEMENT LLC | 3.92%2.36M shares |
D. E. Shaw & Co., Inc. | 3.22%1.94M shares |
Brady Todd C | ≈2.85%1.72M shares |
MARSHALL WACE, LLP | 2.50%1.51M shares |
683 Capital Management, LLC | 2.40%1.45M shares |
JANE STREET GROUP, LLC | 2.28%1.38M shares |
BlackRock, Inc. | 2.08%1.26M shares |
Qube Research & Technologies Ltd | 1.87%1.13M shares |
ACADIAN ASSET MANAGEMENT LLC | 1.76%1.06M shares |
ARDSLEY ADVISORY PARTNERS LP | 1.62%975K shares |
RENAISSANCE TECHNOLOGIES LLC | 1.46%882K shares |
VANGUARD PORTFOLIO MANAGEMENT LLC | 1.32%794.86K shares |
GOLDMAN SACHS GROUP INC | 1.20%725.44K shares |
JACOBS LEVY EQUITY MANAGEMENT, INC | 1.07%646.84K shares |
MORGAN STANLEY | 1.01%608.32K shares |
GEODE CAPITAL MANAGEMENT, LLC | 0.99%596.03K shares |
Percentages use 60.32M shares of this listed class outstanding on Jun 30, 2026. ≈ compares the latest reported holding with a share total from a different date; it is not a confirmed current stake.
Gray completes the 100% scale. Reported positions may overlap; holders have different reporting dates.
| Transaction | Insider | Type | Shares | Price | Value | Owned after |
|---|---|---|---|---|---|---|
| Jun 3, 2026Form 4 | Brady Todd CPresident and CEO | BuyCommon Stock | 250.0K | $1.67 | $417.5K | 1.72M |
| Mar 19, 2026Form 4 | DOUGLAS RICHARDDirector | BuyCommon Stock | 70.0K | $1.40 | $98.0K | 195.0K |
| Mar 18, 2026Form 4 | Alfieri MichaelPrincipal Financial Officer | BuyCommon Stock | 5.0K | $1.42 | $7.1K | 7.5K |
| Aug 13, 2025Form 4 | Alfieri MichaelPrincipal Financial Officer | BuyCommon Stock | 2.5K | $5.30 | $13.3K | 2.5K |
| Aug 11, 2025Form 4 | Machatha StephenChief Development Officer | SellCommon Stock | 22.1K | $5.15 | $113.7K | 221.8K |