Revenue
2015
2016
2017
2018
2019
2020
2021
2022
2023
2024
2025
| 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | $234.6M | $91.3M | $17.2M | $10.3M | $63.2M | $75.0M | $8.0M | $5.0M | $10.0M | $16.7M | $17.6M |
| Research & development | $136.0M | $163.8M | $132.3M | $88.8M | $98.5M | $80.0M | $99.3M | $56.2M | $29.4M | $15.4M | $17.3M |
| Operating expenses | $186.7M | $206.2M | $181.6M | $125.4M | $120.0M | $98.9M | $115.4M | $71.7M | $38.8M | $19.7M | $20.9M |
| Operating income | $47.9M | −$114.9M | −$164.4M | −$115.2M | −$56.8M | −$23.9M | −$107.4M | −$66.7M | −$28.8M | −$3.0M | −$3.3M |
| Operating margin | 20.42% | −125.93% | −958.27% | −1,119.41% | −89.93% | −31.84% | −1,342.90% | −1,334.44% | −287.81% | −18.13% | −18.91% |
| EBITDA | $48.5M | −$114.3M | −$163.8M | −$114.5M | −$56.2M | −$23.3M | −$106.9M | −$66.4M | −$28.6M | −$2.8M | −$3.0M |
| EBITDA margin | 20.65% | −125.27% | −954.47% | −1,112.85% | −88.95% | −31.09% | −1,336.48% | −1,328.14% | −285.98% | −16.73% | −17.35% |
| Net income | −$13.2M | −$145.2M | −$163.6M | −$128.7M | −$57.8M | −$19.9M | −$97.3M | −$61.7M | −$30.1M | −$4.3M | −$5.4M |
| Net profit margin | −5.64% | −159.10% | −953.66% | −1,251.33% | −91.49% | −26.57% | −1,216.70% | −1,233.12% | −300.70% | −25.53% | −30.76% |
| Basic EPSper basic share | -$0.46 | -$5.12 | -$6.08 | -$4.57 | -$2.11 | -$0.73 | -$3.60 | -$2.50 | -$1.52 | -$1.62 | -$2.12 |
| Diluted EPSper diluted share | -$0.46 | -$5.12 | -$6.08 | -$4.57 | -$2.11 | -$0.73 | -$3.60 | -$2.50 | -$1.52 | -$1.62 | -$2.12 |
Reported shareholders
Reported holdings Number of shares
| Holder | Shares held |
|---|---|
EcoR1 Capital, LLC | 7.88M |
BlackRock, Inc. | 1.84M |
TANG CAPITAL MANAGEMENT LLC | 1.33M |
STATE STREET CORP | 1.29M |
VANGUARD CAPITAL MANAGEMENT LLC | 906.23K |
Affinity Asset Advisors, LLC | 826.11K |
Sanofi | 821.92K |
MILLENNIUM MANAGEMENT LLC | 807.32K |
Woodline Partners LP | 717.01K |
683 Capital Management, LLC | 660K |
GEODE CAPITAL MANAGEMENT, LLC | 637.87K |
Palo Alto Investors LP | 603.49K |
GOLDMAN SACHS GROUP INC | 584.07K |
First Light Asset Management, LLC | 582K |
D. E. Shaw & Co., Inc. | 539.67K |
VANGUARD PORTFOLIO MANAGEMENT LLC | 527.86K |
Apis Capital Advisors, LLC | 497K |
Faga Daniel | 495.97K |
Sofinnova Investments, Inc. | 493.54K |
ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 488.65K |
Bars compare reported share counts. A matching total for this share class and reporting period is unavailable, so percentages are not shown.
| Transaction | Insider | Type | Shares | Price | Value | Owned after |
|---|---|---|---|---|---|---|
| Mar 30, 2026Form 4 | Schmid John P.Director | SellCommon Stock | 522 | $57.40 | $30.0K | 31.6K |
| Mar 30, 2026Form 4 | Schmid John P.Director | SellCommon Stock | 7.5K | $56.70 | $426.8K | 32.1K |
| Mar 30, 2026Form 4 | Schmid John P.Director | SellCommon Stock | 12.6K | $55.71 | $701.7K | 39.7K |
| Mar 27, 2026Form 4 | Faga DanielPresident, CEO | SellCommon Stock | 100 | $65.99 | $6.6K | 496.0K |
| Mar 27, 2026Form 4 | Faga DanielPresident, CEO | SellCommon Stock | 3.0K | $65.20 | $198.1K | 496.1K |