Revenue
2022
2023
2024
2025
| 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | $120.8M | $128.9M | $8.6M | $63.6M | — | — | — | — | — | — | — | — | — |
| Research & development | $37.4M | $151.5M | $224.8M | $272.5M | $282.0M | $244.7M | $216.1M | $167.5M | $81.2M | $56.5M | $41.6M | $14.4M | $4.3M |
| Operating expenses | $84.9M | $212.4M | $284.6M | $344.1M | $360.8M | $309.1M | $295.7M | $237.1M | $121.5M | $81.2M | $58.4M | $28.2M | $8.6M |
| Operating income | $35.9M | −$83.4M | −$276.0M | −$280.5M | −$340.5M | −$309.1M | −$295.7M | −$237.1M | −$121.5M | −$81.2M | −$58.4M | −$28.2M | −$8.6M |
| Operating margin | 29.69% | −64.71% | −3,219.48% | −441.25% | — | — | — | — | — | — | — | — | — |
| EBITDA | $38.0M | −$78.4M | −$271.2M | −$274.9M | −$331.1M | −$300.7M | −$288.6M | −$233.4M | −$120.6M | −$80.9M | −$58.4M | −$28.1M | −$8.6M |
| EBITDA margin | 31.45% | −60.79% | −3,163.15% | −432.35% | — | — | — | — | — | — | — | — | — |
| Net income | $32.7M | −$85.4M | −$276.1M | −$228.3M | −$340.1M | −$306.6M | −$291.0M | −$230.7M | −$119.5M | −$79.0M | −$57.2M | −$28.0M | −$8.8M |
| Net profit margin | 27.07% | −66.23% | −3,220.88% | −359.12% | — | — | — | — | — | — | — | — | — |
| Basic EPSper basic share | $2.61 | -$11.41 | -$65.19 | -$56.00 | -$90.75 | -$103.75 | -$141.75 | -$131.75 | -$100.00 | -$68.75 | — | — | — |
| Diluted EPSper diluted share | $2.57 | -$11.41 | -$65.19 | -$56.00 | -$90.75 | -$103.75 | -$141.75 | -$131.75 | -$100.00 | -$68.75 | — | — | — |
Reported shareholders
| Holder | % owned |
|---|---|
EcoR1 Capital, LLC | 16.44%1.55M shares |
Panacea Innovation Ltd / Huang James | ≈13.97%1.32M shares |
Ciongoli Gregory Austin | ≈12.93%1.22M shares |
ADAGE CAPITAL PARTNERS GP, L.L.C. | 9.00%850K shares |
Point72 Asset Management, L.P. | 7.28%687.72K shares |
Redmile Group, LLC | 4.68%441.7K shares |
VANGUARD CAPITAL MANAGEMENT LLC | 2.62%247.05K shares |
MACKENZIE FINANCIAL CORP | 2.47%233.25K shares |
Nguyen AnhCo | ≈1.46%137.84K shares |
BlackRock, Inc. | 0.89%84.46K shares |
Touchon Pascal | ≈0.83%77.96K shares |
GEODE CAPITAL MANAGEMENT, LLC | 0.80%75.13K shares |
Cherry Brian N | ≈0.66%62.32K shares |
Hyllengren Eric J | ≈0.60%56.23K shares |
STALEY CAPITAL ADVISERS INC | 0.53%50K shares |
Grant-Huerta Yanina | ≈0.53%49.64K shares |
VANGUARD FIDUCIARY TRUST CO | 0.46%43.04K shares |
ACADIAN ASSET MANAGEMENT LLC | 0.41%38.85K shares |
HEIDEN WILLIAM K | ≈0.36%34.19K shares |
Gallagher Carol Giltner | —33.01K shares |
Percentages use 9.44M shares of this listed class outstanding on Jun 30, 2026. ≈ compares the latest reported holding with a share total from a different date; it is not a confirmed current stake.
Gray completes the 100% scale. Reported positions may overlap; holders have different reporting dates.
| Transaction | Insider | Type | Shares | Price | Value | Owned after |
|---|---|---|---|---|---|---|
| May 18, 2026Form 4 | Nguyen AnhCoPresident and CEO | SellCommon Stock | 5.2K | $9.13 | $47.9K | 137.8K |
| May 18, 2026Form 4 | Grant-Huerta YaninaChief Accounting Officer | SellCommon Stock | 2.4K | $9.13 | $22.0K | 49.6K |
| May 7, 2026Form 4 | Panacea Innovation Ltd +1TenPercentOwner | SellCommon Stock · indirect | 313.4K | $10.10 | $3.17M | 1.01M |
| May 7, 2026Form 4 | EcoR1 Capital, LLCTenPercentOwner | BuyCommon Stock · indirect | 507.4K | $9.35 | $4.74M | 1.55M |
| Mar 2, 2026Form 4 | Grant-Huerta YaninaChief Accounting Officer | SellCommon Stock | 100 | $5.08 | $508.00 | 31.8K |