Revenue
2022
2023
2024
2025
| 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | $0 | $0 | $0 | $0 | — | — | — | — | — | — | — | — |
| Research & development | $33.7M | $19.4M | $16.5M | $24.5M | $29.1M | $31.8M | $38.0M | $38.6M | $46.3M | $29.4M | $11.4M | $38,000 |
| Operating expenses | $43.0M | $27.5M | $23.4M | $32.6M | $38.6M | $43.8M | $48.9M | $49.2M | $56.5M | $37.0M | $13.8M | — |
| Operating income | −$43.0M | −$27.5M | −$23.4M | −$32.6M | −$38.6M | −$43.8M | −$48.9M | −$49.2M | −$56.5M | −$37.0M | −$13.8M | −$161,000 |
| EBITDA | −$42.9M | −$27.5M | −$23.3M | −$32.2M | −$38.2M | −$43.1M | −$48.1M | −$48.4M | −$55.7M | −$36.4M | −$13.6M | — |
| Net income | −$15.3M | −$62.3M | −$27.0M | −$41.3M | −$43.2M | −$6.0M | −$46.7M | −$46.9M | −$55.7M | −$36.4M | −$31.3M | −$161,000 |
| Basic EPSper basic share | -$0.19 | -$1.02 | -$0.56 | -$0.89 | -$1.03 | -$0.20 | -$1.59 | -$1.71 | -$2.72 | -$2.36 | -$83.86 | -$0.95 |
| Diluted EPSper diluted share | -$0.53 | -$1.02 | -$0.56 | -$0.89 | -$1.03 | -$0.20 | -$1.59 | -$1.71 | -$2.72 | -$2.36 | -$83.86 | -$0.95 |
Reported shareholders
| Holder | % owned |
|---|---|
Thompson Peter A. | ≈10.48%8.82M shares |
ORBIMED ADVISORS LLC | 8.52%7.17M shares |
BlackRock, Inc. | 8.49%7.14M shares |
STATE STREET CORP | 5.32%4.47M shares |
PRICE T ROWE ASSOCIATES INC /MD/ | 4.50%3.79M shares |
VANGUARD CAPITAL MANAGEMENT LLC | 3.91%3.29M shares |
ADAMS STREET PARTNERS LLC | 3.89%3.28M shares |
Vivo Capital, LLC | 3.34%2.81M shares |
WELLINGTON MANAGEMENT GROUP LLP | 3.25%2.73M shares |
PERCEPTIVE ADVISORS LLC | 3.17%2.67M shares |
Deep Track Capital, LP | 2.96%2.49M shares |
MILLER RICHARD A MD | ≈2.77%2.33M shares |
BRAIDWELL LP | 2.53%2.13M shares |
GEODE CAPITAL MANAGEMENT, LLC | 2.20%1.85M shares |
Foresite Capital Management VI LLC | 2.18%1.83M shares |
GOLDMAN SACHS GROUP INC | 1.87%1.58M shares |
Hood River Capital Management LLC | 1.87%1.57M shares |
MORGAN STANLEY | 1.60%1.34M shares |
Boxer Capital Management, LLC | 1.31%1.1M shares |
Catalio Capital Management, LP | 1.28%1.08M shares |
Percentages use 84.12M shares of this listed class outstanding on Jun 30, 2026. ≈ compares the latest reported holding with a share total from a different date; it is not a confirmed current stake.
Gray completes the 100% scale. Reported positions may overlap; holders have different reporting dates.
| Transaction | Insider | Type | Shares | Price | Value | Owned after |
|---|---|---|---|---|---|---|
| Jun 11, 2026Form 4 | Moore David ScottDirector | BuyCommon Stock | 21.7K | $11.53 | $250.2K | 21.7K |
| May 18, 2026Form 4 | MILLER RICHARD A MDPresident and CEO | BuyCommon Stock · indirect | 1.9K | $12.01 | $23.2K | 1.20M |
| May 18, 2026Form 4 | MILLER RICHARD A MDPresident and CEO | BuyCommon Stock · indirect | 5.0K | $12.05 | $60.3K | 1.19M |
| Jun 27, 2025Form 4 | ORBIMED ADVISORS LLC +1Director,TenPercentOwner | SellCommon Stock · indirect | 1.18M | $4.16 | $4.89M | 7.17M |
| Jun 27, 2025Form 4 | Thompson Peter A.Director,TenPercentOwner | SellCommon Stock · indirect | 1.18M | $4.16 | $4.89M | 7.17M |