Revenue
2013
2014
2015
2016
2017
2018
2019
2020
2021
2022
2023
2024
2025
| 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | $76.2M | $138.1M | $101.2M | $53.2M | $37.3M | $68.4M | $26.9M | $59.5M | $71.6M | $12.8M | $7.7M | $5.1M | $888,000 |
| Research & development | $68.7M | $83.4M | $77.7M | $111.6M | $114.2M | $112.9M | $131.6M | $103.9M | $92.3M | $54.8M | $28.4M | $28.3M | $10.9M |
| Operating expenses | $98.6M | $113.1M | $107.7M | $154.5M | $153.4M | $149.0M | $168.4M | $137.4M | $117.9M | $74.6M | $40.9M | $34.8M | $15.8M |
| Operating income | −$22.4M | $25.0M | −$6.5M | −$101.3M | −$116.0M | −$80.5M | −$141.5M | −$77.9M | −$46.3M | −$59.6M | −$33.2M | −$29.8M | −$15.0M |
| Operating margin | −29.35% | 18.10% | −6.41% | −190.61% | −311.00% | −117.70% | −525.92% | −130.88% | −64.59% | −463.88% | −430.54% | −586.27% | −1,684.23% |
| EBITDA | −$21.0M | $26.7M | −$4.3M | −$98.9M | −$113.3M | −$78.0M | −$138.8M | −$76.0M | −$44.6M | −$57.9M | −$32.0M | −$29.0M | −$14.3M |
| EBITDA margin | −27.58% | 19.36% | −4.29% | −186.01% | −303.64% | −113.98% | −516.08% | −127.71% | −62.29% | −450.39% | −414.90% | −570.85% | −1,610.47% |
| Net income | −$17.4M | $31.9M | −$569,000 | −$99.3M | −$115.9M | −$64.8M | −$132.8M | −$84.6M | −$43.1M | −$58.9M | −$35.4M | −$30.3M | −$15.1M |
| Net profit margin | −22.79% | 23.08% | −0.56% | −186.82% | −310.54% | −94.73% | −493.74% | −142.19% | −60.17% | −458.54% | −458.69% | −597.01% | −1,705.29% |
| Basic EPSper basic share | -$0.15 | $0.38 | -$0.01 | -$1.51 | — | — | — | — | -$1.16 | -$1.63 | -$4.90 | -$35.25 | -$24.46 |
| Diluted EPSper diluted share | -$0.15 | $0.38 | -$0.01 | -$1.51 | — | — | — | — | -$1.16 | -$1.63 | -$4.90 | -$35.25 | -$24.46 |
Reported shareholders
Reported holdings Number of shares
| Holder | Shares held |
|---|---|
FMR LLC | 32.71M |
Kynam Capital Management, LP | 21.7M |
BlackRock, Inc. | 17.56M |
BANK OF AMERICA CORP /DE/ | 15.08M |
STATE STREET CORP | 11.75M |
PERCEPTIVE ADVISORS LLC | 10.44M |
VANGUARD CAPITAL MANAGEMENT LLC | 8.53M |
Point72 Asset Management, L.P. | 7.81M |
WELLINGTON MANAGEMENT GROUP LLP | 5.17M |
Venrock Adviser, LLC | 4.98M |
BAKER BROS. ADVISORS LP | 4.98M |
GEODE CAPITAL MANAGEMENT, LLC | 4.68M |
Elmind Capital, LP | 4.55M |
Nextech Invest Ltd. | 4.45M |
TWO SIGMA INVESTMENTS, LP | 4.13M |
Eversept Partners, LP | 3.56M |
UBS Group AG | 3.47M |
Siren, L.L.C. | 3.46M |
ADAR1 Capital Management, LLC | 3.37M |
CITADEL ADVISORS LLC | 3.11M |
Bars compare reported share counts. A matching total for this share class and reporting period is unavailable, so percentages are not shown.
| Transaction | Insider | Type | Shares | Price | Value | Owned after |
|---|---|---|---|---|---|---|
| Jun 15, 2026Form 4 | Ogden ChristopherChief Financial Officer | SellCommon Stock | 1.6K | $3.05 | $5.0K | 295.3K |
| Mar 17, 2026Form 4 | Chu Yu-WayeChief Medical Officer | SellCommon Stock | 21.3K | $6.42 | $136.6K | 189.4K |
| Mar 17, 2026Form 4 · 10b5-1 | McCarthy Sean A.CEO | SellCommon Stock | 119.0K | $6.42 | $763.8K | 1.08M |
| Mar 17, 2026Form 4 | BELVIN MARCIASVP, Chief Scientific Officer | SellCommon Stock | 31.5K | $6.42 | $202.2K | 300.8K |
| Mar 17, 2026Form 4 | Ogden ChristopherChief Financial Officer | SellCommon Stock | 19.3K | $6.42 | $124.1K | 296.9K |