Revenue
2015
2016
2017
2018
2019
2020
2021
2022
2023
2024
2025
| 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | $40.5M | $32.3M | $78.1M | $19.7M | $25.5M | $90.7M | $20.5M | $31.9M | $13.7M | $6.1M | $1.6M | — |
| Research & development | $90.0M | $199.2M | $177.7M | $175.0M | $142.5M | $158.0M | $96.9M | $90.7M | $83.2M | $57.0M | $18.8M | $5.1M |
| Operating expenses | $200.5M | $283.5M | $247.3M | $245.7M | $218.7M | $225.6M | $161.5M | $145.7M | $133.7M | $103.2M | $36.9M | $12.7M |
| Operating income | −$160.0M | −$251.2M | −$169.2M | −$225.9M | −$193.1M | −$134.8M | −$140.9M | −$113.7M | −$119.9M | −$97.2M | −$35.3M | −$12.7M |
| Operating margin | −394.89% | −777.22% | −216.56% | −1,146.26% | −756.13% | −148.61% | −686.39% | −356.10% | −873.64% | −1,605.62% | −2,167.71% | — |
| EBITDA | −$154.7M | −$245.3M | −$163.1M | −$219.6M | −$188.1M | −$130.9M | −$138.1M | −$110.5M | −$117.3M | −$96.0M | −$34.8M | −$12.6M |
| EBITDA margin | −381.87% | −759.25% | −208.80% | −1,114.11% | −736.35% | −144.25% | −672.60% | −345.91% | −854.09% | −1,585.76% | −2,138.80% | — |
| Net income | −$160.1M | −$237.1M | −$153.2M | −$220.4M | −$192.5M | −$116.0M | −$133.7M | −$110.0M | −$120.3M | −$97.2M | −$72.9M | −$13.7M |
| Net profit margin | −395.01% | −733.72% | −196.13% | −1,118.26% | −753.61% | −127.82% | −651.43% | −344.28% | −876.49% | −1,605.53% | −4,475.14% | — |
| Basic EPSper basic share | -$1.80 | -$2.88 | -$2.02 | -$3.21 | -$2.85 | -$1.98 | -$2.68 | -$2.33 | -$2.98 | -$3.02 | -$28.55 | -$12.46 |
| Diluted EPSper diluted share | -$1.80 | -$2.88 | -$2.02 | -$3.21 | -$2.85 | -$1.98 | -$2.68 | -$2.33 | -$2.98 | -$3.02 | -$28.55 | -$12.46 |
Reported shareholders
| Holder | % owned |
|---|---|
TCG Crossover Management, LLC | 11.35%11.11M shares |
BlackRock, Inc. | 10.82%10.59M shares |
RA CAPITAL MANAGEMENT, L.P. | 9.08%8.89M shares |
Commodore Capital LP | 9.08%8.89M shares |
ADAR1 Capital Management, LLC | 9.08%8.89M shares |
VANGUARD CAPITAL MANAGEMENT LLC | 6.28%6.14M shares |
Paradigm Biocapital Advisors LP | 5.71%5.59M shares |
Opaleye Management Inc. | 3.95%3.86M shares |
VANGUARD PORTFOLIO MANAGEMENT LLC | 3.68%3.6M shares |
Woodline Partners LP | 3.63%3.56M shares |
Vivo Capital, LLC | 3.63%3.56M shares |
GordonMD Global Investments LP | 3.20%3.13M shares |
GOLDMAN SACHS GROUP INC | 2.67%2.61M shares |
GEODE CAPITAL MANAGEMENT, LLC | 2.63%2.57M shares |
RENAISSANCE TECHNOLOGIES LLC | 2.52%2.47M shares |
Logos Global Management LP | 2.27%2.22M shares |
STATE STREET CORP | 2.24%2.19M shares |
MARSHALL WACE, LLP | 2.08%2.04M shares |
D. E. Shaw & Co., Inc. | 1.94%1.9M shares |
JPMORGAN CHASE & CO | 1.90%1.86M shares |
Percentages use 97.87M shares of this listed class outstanding on Jun 30, 2026.
Gray completes the 100% scale. Reported positions may overlap; holders have different reporting dates.
| Transaction | Insider | Type | Shares | Price | Value | Owned after |
|---|---|---|---|---|---|---|
| Jun 3, 2026Form 4 · 10b5-1 | Parison AmySVP, Chief Financial Officer | SellCommon Stock | 464 | $2.70 | $1.3K | 15.0K |
| Jun 3, 2026Form 4 · 10b5-1 | O'Neill Gilmore NeilCEO | SellCommon Stock | 15.4K | $2.70 | $41.5K | 248.3K |
| Jun 3, 2026Form 4 · 10b5-1 | Burkly LindaEVP, CHIEF SCIENTIFIC OFFICER | SellCommon Stock | 731 | $2.70 | $2.0K | 67.3K |
| Mar 3, 2026Form 4 · 10b5-1 | O'Neill Gilmore NeilCEO | SellCommon Stock | 5.4K | $2.02 | $10.9K | 263.7K |
| Mar 3, 2026Form 4 · 10b5-1 | Parison AmySVP, Chief Financial Officer | SellCommon Stock | 474 | $2.02 | $957.48 | 15.4K |