Revenue
2009
2010
2011
2012
2013
2014
2015
2016
2017
2018
2019
2020
2021
2022
2023
2024
2025
| 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | $49.8M | $6.0M | $1.1M | $0 | $0 | $23.4M | $32.3M | $26.6M | $15.9M | $0 | $130.0M | $22.9M | $2.2M | $1.1M | $1.8M | $4.9M | $10.7M |
| Gross profit | $49.5M | $5.4M | $1.0M | $0 | $0 | $21.5M | $29.1M | $24.1M | $14.0M | $0 | $130.0M | — | — | — | — | — | — |
| Gross margin | 99.45% | 89.74% | 92.34% | — | — | 91.76% | 90.01% | 90.63% | 88.05% | — | 100.00% | — | — | — | — | — | — |
| Research & development | $61.1M | $84.5M | $58.9M | $52.8M | $55.0M | $153.6M | $91.9M | $100.2M | $152.2M | $164.0M | $95.2M | $89.3M | $89.7M | $82.6M | $91.8M | $78.5M | $81.2M |
| Operating expenses | $98.7M | $202.5M | $173.0M | $100.9M | $87.4M | $204.4M | $180.6M | $166.5M | $222.3M | $206.4M | $128.5M | $123.2M | $104.6M | $109.5M | $115.9M | $100.6M | $100.7M |
| Operating income | −$48.9M | −$197.1M | −$171.8M | −$100.8M | −$87.1M | −$47.8M | $141.4M | −$103.3M | −$130.6M | −$127.2M | $1.5M | −$100.4M | −$102.4M | −$108.4M | −$114.1M | −$95.7M | −$90.0M |
| Operating margin | −98.21% | −3,284.74% | −15,472.97% | — | — | −204.24% | 437.49% | −388.52% | −822.05% | — | 1.13% | −439.16% | −4,607.16% | −9,955.46% | −6,170.63% | −1,950.24% | −840.71% |
| EBITDA | −$48.3M | −$196.6M | −$171.2M | −$100.3M | −$86.8M | −$44.9M | $145.1M | −$99.6M | −$127.2M | −$125.1M | $2.2M | −$98.4M | −$99.5M | −$104.2M | −$109.2M | −$90.3M | −$83.8M |
| EBITDA margin | −96.96% | −3,275.84% | −15,423.06% | — | — | −191.70% | 448.79% | −374.66% | −800.66% | — | 1.69% | −430.73% | −4,478.31% | −9,570.71% | −5,906.33% | −1,840.34% | −783.15% |
| Net income | −$50.3M | −$200.4M | −$177.1M | −$101.9M | −$87.8M | −$58.6M | $130.1M | −$120.5M | −$123.0M | −$131.4M | −$4.7M | −$100.3M | −$104.1M | −$110.2M | −$116.2M | −$101.8M | −$82.8M |
| Net profit margin | −101.08% | −3,339.49% | −15,956.67% | — | — | −250.27% | 402.50% | −453.48% | −774.03% | — | −3.60% | −438.85% | −4,686.14% | −10,120.39% | −6,285.29% | −2,073.66% | −773.64% |
| Basic EPSper basic share | -$0.14 | -$0.63 | -$0.80 | -$0.62 | -$0.60 | -$0.53 | $1.23 | -$1.14 | -$1.17 | -$1.27 | -$0.05 | -$1.31 | -$1.42 | -$0.23 | -$0.34 | -$0.34 | -$0.57 |
| Diluted EPSper diluted share | -$0.14 | -$0.63 | -$0.80 | -$0.62 | -$0.60 | -$0.53 | $1.16 | -$1.14 | -$1.17 | -$1.27 | -$0.05 | -$1.31 | -$1.42 | -$0.23 | -$0.34 | -$0.34 | -$0.57 |
Reported shareholders
| Holder | % owned |
|---|---|
Artal Group S.A. | 39.20%175.16M shares |
Artal Participations S.a r.l. | ≈30.47%136.18M shares |
FMR LLC | 11.59%51.78M shares |
DEBBANE RAYMOND | ≈11.58%51.75M shares |
Siren, L.L.C. | 9.91%44.3M shares |
Sessa Capital IM, L.P. | 4.24%18.96M shares |
BlackRock, Inc. | 3.88%17.35M shares |
VANGUARD CAPITAL MANAGEMENT LLC | 2.22%9.9M shares |
Point72 Asset Management, L.P. | 1.85%8.25M shares |
GEODE CAPITAL MANAGEMENT, LLC | 1.40%6.24M shares |
STATE STREET CORP | 1.10%4.92M shares |
VANGUARD PORTFOLIO MANAGEMENT LLC | 0.53%2.36M shares |
NORTHERN TRUST CORP | 0.44%1.97M shares |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0.44%1.96M shares |
VANGUARD FIDUCIARY TRUST CO | 0.37%1.63M shares |
CITADEL ADVISORS LLC | 0.36%1.6M shares |
Avicenna Life Sci Master GP LLC / Avicenna Life Sci Master Fund LP | ≈0.34%1.54M shares |
Ishara Investments LP | 0.28%1.27M shares |
MILLENNIUM MANAGEMENT LLC | 0.25%1.13M shares |
RENAISSANCE TECHNOLOGIES LLC | 0.25%1.13M shares |
Percentages use 446.87M shares of this listed class outstanding on Jun 30, 2026. ≈ compares the latest reported holding with a share total from a different date; it is not a confirmed current stake.
Reported positions exceed 100% in total, so the circle shows the selected holder only.
| Transaction | Insider | Type | Shares | Price | Value | Owned after |
|---|---|---|---|---|---|---|
| Feb 25, 2026Form 4 | DEBBANE RAYMONDDirector | BuyCommon Stock | 2.0K | $1.49 | $3.0K | 1.91M |
| Feb 23, 2026Form 4 | DEBBANE RAYMONDDirector | BuyCommon Stock | 100.0K | $1.47 | $147.0K | 1.90M |
| Feb 20, 2026Form 4 | DEBBANE RAYMONDDirector | BuyCommon Stock | 100.0K | $1.48 | $148.0K | 1.80M |
| Feb 19, 2026Form 4 | DEBBANE RAYMONDDirector | BuyCommon Stock | 50.0K | $1.44 | $72.0K | 1.70M |
| Feb 18, 2026Form 4 | DEBBANE RAYMONDDirector | BuyCommon Stock | 133.7K | $1.32 | $176.5K | 1.65M |