Revenue
2009
2010
2011
2012
2013
2014
2015
2016
2017
2018
2019
2020
2021
2022
2023
2024
2025
| 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | $55.2M | $98.4M | $90.1M | $92.1M | $101.9M | $152.9M | $114.6M | $1.19B | $307.7M | $165.4M | $230.8M | $200.7M | $148.9M | $81.2M | $71.5M | $159.0M | $71.9M |
| Gross profit | $55.2M | $67.7M | $56.4M | $70.4M | $77.0M | $133.4M | $93.2M | $1.17B | $277.2M | $135.2M | $196.7M | $172.2M | $110.4M | $50.8M | $49.6M | $133.4M | $41.0M |
| Gross margin | 100.00% | 68.82% | 62.53% | 76.50% | 75.57% | 87.26% | 81.35% | 97.95% | 90.07% | 81.74% | 85.22% | 85.78% | 74.14% | 62.52% | 69.37% | 83.86% | 56.98% |
| Research & development | $117.3M | $120.9M | $114.2M | $218.3M | $400.3M | $408.7M | $434.6M | $399.5M | $268.5M | $203.8M | $182.8M | $147.7M | $190.0M | $148.7M | $126.8M | $108.1M | $95.1M |
| Operating expenses | $195.3M | $203.6M | $353.8M | $468.2M | $548.0M | $578.0M | $554.7M | $505.4M | $367.4M | $278.3M | $260.2M | $217.2M | $269.1M | $222.4M | $195.4M | $187.3M | $167.1M |
| Operating income | −$140.1M | −$105.2M | −$263.7M | −$376.2M | −$446.1M | −$425.1M | −$440.0M | $687.9M | −$59.6M | −$112.9M | −$29.4M | −$16.5M | −$120.1M | −$141.2M | −$123.9M | −$28.3M | −$95.1M |
| Operating margin | −253.66% | −106.88% | −292.59% | −408.63% | −437.76% | −278.00% | −383.92% | 57.65% | −19.38% | −68.22% | −12.73% | −8.21% | −80.67% | −173.91% | −173.39% | −17.77% | −132.25% |
| EBITDA | −$139.1M | −$101.1M | −$256.7M | −$364.0M | −$433.1M | −$412.6M | −$429.0M | $696.7M | −$47.0M | −$99.7M | −$18.0M | −$3.6M | −$105.9M | −$126.7M | −$109.0M | −$11.7M | −$80.3M |
| EBITDA margin | −251.80% | −102.71% | −284.82% | −395.38% | −425.00% | −269.83% | −374.32% | 58.39% | −15.29% | −60.24% | −7.79% | −1.77% | −71.08% | −156.04% | −152.47% | −7.36% | −111.57% |
| Net income | −$164.1M | −$119.0M | −$276.1M | −$368.2M | −$523.8M | −$444.4M | −$440.7M | $681.3M | −$96.7M | −$153.5M | −$81.2M | −$53.9M | −$162.0M | −$171.9M | −$134.0M | −$37.9M | −$102.5M |
| Net profit margin | −297.07% | −120.86% | −306.31% | −399.98% | −514.03% | −290.65% | −384.47% | 57.09% | −31.42% | −92.80% | −35.17% | −26.86% | −108.79% | −211.67% | −187.43% | −23.85% | −142.52% |
| Basic EPSper basic share | -$9.73 | -$8.68 | -$310.71 | -$422.14 | -$612.86 | -$533.57 | -$540.00 | $861.43 | -$132.86 | -$235.71 | -$130.71 | -$90.00 | -$300.00 | -$321.43 | -$255.00 | -$85.71 | -$237.86 |
| Diluted EPSper diluted share | -$9.73 | -$8.68 | -$310.71 | -$422.14 | -$612.86 | -$533.57 | -$540.00 | $810.00 | -$132.86 | -$235.71 | -$130.71 | -$90.00 | -$300.00 | -$321.43 | -$255.00 | -$85.71 | -$237.86 |
Reported shareholders
| Holder | % owned |
|---|---|
FMR LLC | 24.87%5.07M shares |
Two Seas Capital LP | 15.17%3.09M shares |
BlackRock, Inc. | 14.44%2.94M shares |
BVF INC/IL | 11.73%2.39M shares |
VANGUARD CAPITAL MANAGEMENT LLC | 7.35%1.5M shares |
TWO SIGMA INVESTMENTS, LP | 5.90%1.2M shares |
Vestal Point Capital, LP | 4.91%1M shares |
MORGAN STANLEY | 4.60%936.56K shares |
STATE STREET CORP | 4.46%909.68K shares |
GEODE CAPITAL MANAGEMENT, LLC | 4.32%881.31K shares |
Prosight Management, LP | 3.97%810K shares |
ARMISTICE CAPITAL, LLC | 3.55%724K shares |
GILDER GAGNON HOWE & CO LLC | 2.95%600.87K shares |
MILLENNIUM MANAGEMENT LLC | 2.35%478.12K shares |
BRAIDWELL LP | 2.32%473.62K shares |
Sofinnova Investments, Inc. | 2.31%471.76K shares |
Woodline Partners LP | 2.31%470.88K shares |
ORBIMED ADVISORS LLC | 2.28%465.35K shares |
UBS Group AG | 2.10%428.4K shares |
EMERALD ADVISERS, LLC | 1.91%390.16K shares |
Percentages use 20.38M shares of this listed class outstanding on Jun 30, 2026.
Reported positions exceed 100% in total, so the circle shows the selected holder only.
| Transaction | Insider | Type | Shares | Price | Value | Owned after |
|---|---|---|---|---|---|---|
| Jun 17, 2026Form 4 · 10b5-1 | ROBIN HOWARD WPresident & CEO | SellCommon Stock | 4.5K | $61.65 | $277.4K | 55.0K |
| Jun 17, 2026Form 4 · 10b5-1 | ROBIN HOWARD WPresident & CEO | SellCommon Stock | 5.5K | $60.81 | $334.5K | 59.5K |
| Jun 16, 2026Form 4 · 10b5-1 | ROBIN HOWARD WPresident & CEO | SellCommon Stock | 4.7K | $60.71 | $285.2K | 65.0K |
| Jun 16, 2026Form 4 · 10b5-1 | ROBIN HOWARD WPresident & CEO | SellCommon Stock | 5.3K | $59.97 | $318.0K | 69.7K |
| Jun 15, 2026Form 4 · 10b5-1 | Zalevsky JonathanChief R&D Officer | SellCommon Stock | 5.5K | $60.71 | $336.2K | 15.4K |