Revenue
2012
2014
2015
2016
2017
2018
2019
2020
2021
2022
2023
2024
2025
| 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | $52.0M | $63.7M | $58.4M | $51.5M | $43.5M | $17.4M | $4.2M | $2.0M | $1.9M | $1.9M | $1.8M | $772,000 | — | $10,000 |
| Gross profit | $45.4M | $58.1M | $53.2M | $47.0M | $39.1M | $15.3M | $1.9M | $1.5M | $1.5M | $1.4M | $1.4M | $681,000 | — | $3,000 |
| Gross margin | 87.35% | 91.17% | 90.96% | 91.18% | 89.88% | 88.03% | 45.00% | 76.63% | 76.24% | 76.52% | 81.77% | 88.21% | — | 30.00% |
| Research & development | $197.1M | $127.6M | $61.1M | $53.5M | $50.1M | $28.7M | $41.1M | $36.9M | $30.9M | $27.1M | $26.6M | $18.9M | $10.5M | $11.5M |
| Operating expenses | $322.0M | $235.5M | $140.8M | $130.1M | $121.6M | $80.3M | $90.0M | $61.1M | $63.8M | $45.2M | $39.9M | $27.9M | $12.9M | $13.7M |
| Operating income | −$270.0M | −$171.8M | −$82.4M | −$78.7M | −$78.0M | −$62.8M | −$85.8M | −$59.1M | −$61.9M | −$43.3M | −$38.2M | −$27.1M | −$12.9M | −$13.7M |
| Operating margin | −519.75% | −269.57% | −140.96% | −152.74% | −179.30% | −361.13% | −2,029.86% | −2,970.75% | −3,220.12% | −2,296.03% | −2,182.69% | −3,509.59% | — | −136,710.00% |
| EBITDA | −$265.7M | −$168.0M | −$79.4M | −$76.5M | −$75.6M | −$60.1M | −$83.3M | −$56.8M | −$60.3M | −$42.4M | −$37.4M | −$26.5M | −$12.5M | −$13.3M |
| EBITDA margin | −511.43% | −263.63% | −135.86% | −148.65% | −173.74% | −345.19% | −1,970.00% | −2,855.88% | −3,135.62% | −2,249.34% | −2,139.60% | −3,438.73% | — | −132,670.00% |
| Net income | −$265.9M | −$193.5M | −$80.7M | −$71.0M | −$6.6M | −$155.6M | −$86.4M | −$60.0M | −$63.4M | −$44.7M | −$39.7M | −$28.6M | −$13.3M | −$14.1M |
| Net profit margin | −511.90% | −303.67% | −138.14% | −137.95% | −15.06% | −894.31% | −2,043.34% | −3,013.97% | −3,296.20% | −2,369.00% | −2,271.31% | −3,710.88% | — | −140,930.00% |
| Basic EPSper basic share | -$1.42 | -$1.22 | -$1.01 | -$0.92 | -$0.09 | -$2.56 | -$1.91 | -$1.57 | -$2.20 | -$1.80 | -$1.71 | -$2.69 | -$5.11 | -$5.60 |
| Diluted EPSper diluted share | -$1.42 | -$1.22 | -$1.02 | -$0.97 | -$0.98 | -$2.56 | -$1.91 | -$1.57 | -$2.20 | -$1.80 | -$1.71 | -$2.69 | -$5.11 | -$5.60 |
Reported shareholders
| Holder | % owned |
|---|---|
FMR LLC | 14.96%32.84M shares |
Deep Track Capital, LP | 8.97%19.69M shares |
BlackRock, Inc. | 8.82%19.38M shares |
Avoro Capital Advisors LLC | 5.71%12.54M shares |
Summer Road LLC | 5.56%12.21M shares |
Venrock Adviser, LLC | 4.71%10.35M shares |
VANGUARD CAPITAL MANAGEMENT LLC | 4.02%8.83M shares |
PRICE T ROWE ASSOCIATES INC /MD/ | 3.47%7.62M shares |
Logos Global Management LP | 2.41%5.3M shares |
STATE STREET CORP | 2.38%5.23M shares |
GEODE CAPITAL MANAGEMENT, LLC | 2.29%5.02M shares |
Point72 Asset Management, L.P. | 1.50%3.29M shares |
Dugel Pravin | ≈1.50%3.29M shares |
DIMENSIONAL FUND ADVISORS LP | 1.27%2.78M shares |
DELTEC ASSET MANAGEMENT LLC | 1.13%2.48M shares |
Balyasny Asset Management L.P. | 1.03%2.27M shares |
Octagon Capital Advisors LP | 0.94%2.08M shares |
VANGUARD PORTFOLIO MANAGEMENT LLC | 0.90%1.97M shares |
NORTHERN TRUST CORP | 0.82%1.8M shares |
GOLDMAN SACHS GROUP INC | 0.80%1.76M shares |
Percentages use 219.59M shares of this listed class outstanding on Jun 30, 2026. ≈ compares the latest reported holding with a share total from a different date; it is not a confirmed current stake.
Gray completes the 100% scale. Reported positions may overlap; holders have different reporting dates.
| Transaction | Insider | Type | Shares | Price | Value | Owned after |
|---|---|---|---|---|---|---|
| Jun 3, 2026Form 4 · 10b5-1 | Waheed NadiaChief Medical Officer | SellCommon Stock | 14.8K | $8.27 | $122.6K | 300.1K |
| May 26, 2026Form 4 · 10b5-1 | Dugel PravinSee Remarks | SellCommon Stock | 21.2K | $8.20 | $173.5K | 2.60M |
| May 26, 2026Form 4 · 10b5-1 | Kaiser PeterChief Development Officer | SellCommon Stock | 3.0K | $8.20 | $24.3K | 266.1K |
| May 26, 2026Form 4 · 10b5-1 | Heier Jeffrey S.Chief Scientific Officer | SellCommon Stock | 3.0K | $8.20 | $24.7K | 320.4K |
| May 26, 2026Form 4 · 10b5-1 | Nayak SanjayChief Strategy Officer | SellCommon Stock | 1.9K | $8.20 | $15.2K | 328.8K |