Prime Medicine annual return on equity
2022
2023
2024
2025
Prime Medicine Return on Equity (ROE) Growth & History (PRME)
Prime Medicine's return on equity was −146.81% for fiscal 2025.
View full Prime Medicine company overviewPrime Medicine annual return on equity history
| Fiscal year | Period ended | Return on equity | Change (percentage points) |
|---|---|---|---|
| 2025 | 2025-12-31 | −146.81% | −9.93 pp |
| 2024 | 2024-12-31 | −136.88% | −48.69 pp |
| 2023 | 2023-12-31 | −88.19% | +64.06 pp |
| 2022 | 2022-12-31 | −152.25% | — |
Prime Medicine quarterly return on equity
Q4.22
Q1.23
Q2.23
Q3.23
Q4.23
Q1.24
Q2.24
Q3.24
Q4.24
Q1.25
Q2.25
Q3.25
Q4.25
Q1.26
Q2.26
| Fiscal quarter | Period ended | Return on equity | Change (percentage points) |
|---|---|---|---|
| Q2 2026 | 2026-06-30 | −72.28% | −9.60 pp |
| Q1 2026 | 2026-03-31 | −49.73% | −9.82 pp |
| Q4 2025 | 2025-12-31 | −32.60% | −7.92 pp |
| Q3 2025 | 2025-09-30 | −45.43% | −18.23 pp |
| Q2 2025 | 2025-06-30 | −62.69% | −37.56 pp |
| Q1 2025 | 2025-03-31 | −39.90% | −15.62 pp |
| Q4 2024 | 2024-12-31 | −24.68% | +15.47 pp |
| Q3 2024 | 2024-09-30 | −27.20% | −3.84 pp |
| Q2 2024 | 2024-06-30 | −25.13% | −8.79 pp |
| Q1 2024 | 2024-03-31 | −24.29% | −11.05 pp |
| Q4 2023 | 2023-12-31 | −40.15% | +44.18 pp |
| Q3 2023 | 2023-09-30 | −23.36% | — |
| Q2 2023 | 2023-06-30 | −16.34% | — |
| Q1 2023 | 2023-03-31 | −13.24% | — |
| Q4 2022 | 2022-12-31 | −84.32% | — |
Prime Medicine return on equity trends
Between the periods ended 2022-12-31 and 2025-12-31, Prime Medicine's return on equity increased from −152.25% to −146.81%, a change of +5.44 percentage points. The latest reported quarter, Q2 2026, shows −72.28%.
About the metric
What return on equity (ROE) means
Return on equity (ROE) measures how much net income a company generates relative to shareholders’ equity. It can help evaluate how efficiently equity capital is used, but unusually high or negative values may reflect leverage, losses, or a small equity base.
Calculation and source
How return on equity is calculated
TickerStat calculates ROE as SEC-reported net income divided by average stockholders’ equity at the beginning and end of the fiscal period. Periods with missing or non-positive average equity are omitted. Quarterly ROE uses quarterly net income and is not annualized. Fiscal periods can differ from calendar years, so exact period-end dates are included.
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