Revenue
2012
2013
2014
2015
2016
2017
2018
2019
2020
2021
2022
2023
2024
2025
| 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | $9.7M | $135.2M | $91.4M | $53.9M | $200.6M | $853,000 | $814,000 | $955,000 | $27.5M | $1.1M | $1.6M | $50.9M | $676,000 | $2.7M | — |
| Research & development | $134.9M | $222.5M | $220.6M | $135.6M | $82.3M | $74.9M | $50.8M | $101.2M | $134.5M | $119.5M | $58.4M | $38.5M | $26.1M | $34.1M | $24.2M |
| Operating expenses | $224.3M | $289.7M | $282.4M | $185.5M | $128.6M | $113.6M | $86.5M | $159.8M | $182.8M | $160.6M | $81.5M | $57.5M | $41.1M | $44.1M | $29.8M |
| Operating income | −$214.6M | −$154.6M | −$191.0M | −$131.6M | $72.0M | −$112.7M | −$85.7M | −$158.9M | −$155.3M | −$159.5M | −$79.9M | −$6.6M | −$40.4M | −$41.4M | −$29.2M |
| Operating margin | −2,216.44% | −114.36% | −209.08% | −244.05% | 35.88% | −13,216.18% | −10,527.89% | −16,634.03% | −564.17% | −15,121.80% | −4,974.30% | −13.07% | −5,980.33% | −1,557.94% | — |
| EBITDA | −$213.7M | −$153.7M | −$190.1M | −$130.8M | $73.1M | −$111.2M | −$84.1M | −$155.6M | −$152.2M | −$157.1M | −$79.1M | −$5.9M | −$39.8M | −$40.9M | −$28.9M |
| EBITDA margin | −2,207.20% | −113.70% | −208.06% | −242.67% | 36.44% | −13,038.69% | −10,335.75% | −16,297.28% | −553.03% | −14,891.75% | −4,924.14% | −11.61% | −5,882.69% | −1,540.33% | — |
| Net income | −$244.1M | −$122.3M | −$147.0M | −$116.9M | $67.0M | −$111.1M | −$77.7M | −$155.6M | −$153.2M | −$160.1M | −$80.6M | −$7.2M | −$41.0M | −$41.4M | −$29.7M |
| Net profit margin | −2,520.57% | −90.49% | −160.91% | −216.95% | 33.39% | −13,029.78% | −9,542.63% | −16,297.91% | −556.84% | −15,176.11% | −5,016.30% | −14.06% | −6,064.50% | −1,557.98% | — |
| Basic EPSper basic share | -$4.53 | -$2.27 | -$2.76 | -$2.47 | $1.51 | -$2.78 | -$1.95 | -$3.93 | -$4.07 | -$4.66 | -$2.66 | -$0.29 | -$2.20 | -$2.84 | -$2.05 |
| Diluted EPSper diluted share | -$4.53 | -$2.27 | -$2.76 | -$2.47 | $1.38 | -$2.78 | -$1.95 | -$3.93 | -$4.07 | -$4.66 | -$2.66 | -$0.29 | -$2.20 | -$2.84 | -$2.05 |
Reported shareholders
Reported holdings Number of shares
| Holder | Shares held |
|---|---|
EcoR1 Capital, LLC | 5.3M |
SCULLY WILLIAM P | 888K |
Kinney Gene G. | 152.79K |
Smith Brandon S. | 130K |
Nguyen Tran | 97.21K |
Zago Wagner M. | 85K |
Swanson Chad J. | 85K |
Malecek Michael J | 80K |
Kingston Anne Evans | 66.94K |
Isaacs Michael John | 48.83K |
Walker Karin L | 25K |
Bars compare reported share counts. A matching total for this share class and reporting period is unavailable, so percentages are not shown.
| Transaction | Insider | Type | Shares | Price | Value | Owned after |
|---|---|---|---|---|---|---|
| Jun 16, 2026Form 4 | SCULLY WILLIAM PTenPercentOwner | BuyOrdinary Shares, par value $0.01 per share | 20.0K | $7.90 | $158.0K | 756.0K |
| Jun 11, 2026Form 4 | SCULLY WILLIAM PTenPercentOwner | BuyOrdinary Shares, par value $0.01 per share | 125.0K | $8.17 | $1.02M | 1.06M |
| Jun 4, 2026Form 4 | SCULLY WILLIAM PTenPercentOwner | BuyOrdinary Shares, par value $0.01 per share | 50.0K | $9.31 | $465.5K | 936.0K |
| Jun 2, 2026Form 4 | SCULLY WILLIAM PTenPercentOwner | BuyOrdinary Shares, par value $0.01 per share | 50.0K | $9.43 | $471.5K | 886.0K |
| May 22, 2026Form 4 | SCULLY WILLIAM PTenPercentOwner | BuyOrdinary Shares, par value $0.01 per share | 100.0K | $9.81 | $981.0K | 836.0K |