Revenue
2021
2022
2023
2024
2025
| 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | |
|---|---|---|---|---|---|---|
| Revenue | $3.5M | $10.7M | $0 | $12.5M | $0 | — |
| Research & development | $29.4M | $21.1M | $27.2M | $37.0M | $40.2M | $25.7M |
| Operating expenses | $45.6M | $36.2M | $45.8M | $56.8M | $54.4M | $32.8M |
| Operating income | −$42.1M | −$25.5M | −$45.8M | −$44.3M | −$54.4M | −$32.8M |
| Operating margin | −1,210.58% | −239.69% | — | −354.71% | — | — |
| EBITDA | −$41.6M | −$24.1M | −$43.9M | −$42.4M | −$52.3M | −$30.9M |
| EBITDA margin | −1,195.14% | −226.16% | — | −339.07% | — | — |
| Net income | −$242.0M | −$63.6M | −$43.0M | −$36.0M | −$54.6M | −$32.7M |
| Net profit margin | −6,960.77% | −596.56% | — | −288.03% | — | — |
| Basic EPSper basic share | -$32.37 | -$21.67 | -$21.33 | -$15.56 | -$33.15 | — |
| Diluted EPSper diluted share | -$32.37 | -$21.67 | -$21.33 | -$15.56 | -$33.15 | — |
Reported shareholders
| Holder | % owned |
|---|---|
Column Group Opportunity III GP, LP / Svennilson Peter / TCG Opportunity III GP, LLC / Column Group Opportunity III, LP / COLUMN GROUP III, LP / COLUMN GROUP III GP, LP / COLUMN GROUP III-A, LP | ≈19.24%2.26M shares |
Kutzkey Tim | ≈19.24%2.26M shares |
TCG Crossover Management, LLC | 12.53%1.47M shares |
Boxer Capital Management, LLC | 9.41%1.11M shares |
Kalehua Capital Management LLC | 6.55%770.36K shares |
MILLENNIUM MANAGEMENT LLC | 5.81%683.08K shares |
Point72 Asset Management, L.P. | 5.65%664.27K shares |
Venrock Adviser, LLC | 5.38%632.93K shares |
STEMPOINT CAPITAL LP | 5.13%602.8K shares |
PERCEPTIVE ADVISORS LLC | 4.29%503.99K shares |
Spruce Street Capital LP | 3.68%432.04K shares |
BlackRock, Inc. | 3.36%394.86K shares |
VANGUARD CAPITAL MANAGEMENT LLC | 3.34%392.55K shares |
BRAIDWELL LP | 3.32%390.75K shares |
Vestal Point Capital, LP | 2.59%304.67K shares |
5AM Venture Management, LLC | 2.31%271.25K shares |
Vivo Capital, LLC | 2.21%260K shares |
Balyasny Asset Management L.P. | 1.74%205.03K shares |
GEODE CAPITAL MANAGEMENT, LLC | 1.72%201.65K shares |
ACUTA CAPITAL PARTNERS, LLC | 1.48%173.4K shares |
Percentages use 11.75M shares of this listed class outstanding on Jun 30, 2026. ≈ compares the latest reported holding with a share total from a different date; it is not a confirmed current stake.
Reported positions exceed 100% in total, so the circle shows the selected holder only.
| Transaction | Insider | Type | Shares | Price | Value | Owned after |
|---|---|---|---|---|---|---|
| May 4, 2026Form 4 | Li YangExec. Vice President, Research | SellCommon Stock | 1.6K | $33.33 | $52.8K | 17.2K |
| May 4, 2026Form 4 | Williams Charles OChief Operating Officer | SellCommon Stock | 2.0K | $33.33 | $67.9K | 16.6K |
| May 4, 2026Form 4 | Parker Craig CChief Executive Officer | SellCommon Stock | 4.5K | $33.33 | $150.8K | 16.6K |
| Mar 24, 2026Form 4 | TCG Crossover Fund II, L.P. +3TenPercentOwner | BuyCommon Stock · indirect | 53.3K | $24.69 | $1.32M | 736.5K |
| Mar 24, 2026Form 4 | TCG Crossover Fund II, L.P. +3TenPercentOwner | BuyCommon Stock · indirect | 53.3K | $24.69 | $1.32M | 736.6K |