Revenue
2011
2012
2013
2014
2015
2016
2022
2023
2024
2025
| 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 · Dec 31 | 2015 · Apr 30 | 2014 | 2013 | 2012 | 2011 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | $0 | $0 | $0 | $0 | — | — | — | — | — | $0 | — | $49,286 | $158,926 | $1.2M | $363,781 | $103,167 |
| Gross profit | — | — | — | — | — | — | — | — | — | $0 | — | $0 | −$104,069 | $49,572 | $49,266 | $103,167 |
| Gross margin | — | — | — | — | — | — | — | — | — | — | — | 0.00% | −65.48% | 4.16% | 13.54% | 100.00% |
| Research & development | $32.7M | $12.7M | $3.2M | $5.4M | $25.1M | $4.6M | $3.5M | $1.2M | $3.5M | $13.1M | $6.5M | $6.7M | $3.0M | $2.5M | $2.5M | $2.7M |
| Operating expenses | $56.4M | $19.5M | $8.2M | $11.1M | $32.7M | $9.9M | $8.6M | $6.9M | $9.2M | $52.7M | $10.4M | $14.9M | $16.8M | $6.4M | $8.6M | $10.7M |
| Operating income | −$56.4M | −$19.5M | −$8.2M | $11.1M | −$32.7M | $9.9M | −$8.6M | −$6.9M | −$9.2M | −$52.7M | −$10.4M | −$14.8M | −$16.6M | −$5.2M | −$8.2M | $10.6M |
| Operating margin | — | — | — | — | — | — | — | — | — | — | — | −30,062.78% | −10,452.11% | −435.71% | −2,259.66% | 10,238.43% |
| EBITDA | −$52.6M | −$19.5M | −$8.2M | $11.1M | −$32.7M | $9.9M | −$8.6M | −$6.9M | −$9.2M | −$52.6M | −$10.4M | −$14.7M | −$16.5M | −$5.0M | −$8.0M | $10.9M |
| EBITDA margin | — | — | — | — | — | — | — | — | — | — | — | −29,762.21% | −10,357.42% | −423.22% | −2,202.84% | 10,539.90% |
| Net income | −$52.6M | −$17.6M | −$7.7M | $11.0M | −$32.5M | −$9.9M | −$8.4M | −$14.1M | −$8.8M | −$43.9M | −$10.1M | −$14.1M | −$19.5M | −$9.4M | −$15.7M | $10.4M |
| Net profit margin | — | — | — | — | — | — | — | — | — | — | — | −28,571.63% | −12,296.19% | −790.63% | −4,319.19% | 10,127.56% |
| Basic EPSper basic share | -$1.34 | -$1.15 | -$31.04 | -$600.71 | -$2,528.00 | -$1,520.00 | -$2,160.00 | -$14,464.00 | -$10,032.00 | -$49,984.00 | -$11,520.00 | -$16,000.00 | -$86,720.00 | -$201,280.00 | -$387,840.00 | -$288,000.00 |
| Diluted EPSper diluted share | -$1.34 | -$1.15 | -$31.04 | -$600.71 | -$2,528.00 | -$1,520.00 | -$2,160.00 | -$14,464.00 | -$10,032.00 | -$49,984.00 | -$11,520.00 | -$16,000.00 | -$86,720.00 | -$213,760.00 | -$450,240.00 | -$288,000.00 |
Reported shareholders
| Holder | % owned |
|---|---|
FMR LLC | 12.34%3.94M shares |
Vivo Capital, LLC | 7.82%2.5M shares |
BlackRock, Inc. | 5.41%1.73M shares |
PERCEPTIVE ADVISORS LLC | 5.32%1.7M shares |
VANGUARD CAPITAL MANAGEMENT LLC | 3.59%1.15M shares |
MILLENNIUM MANAGEMENT LLC | 2.74%876.23K shares |
Ikarian Capital, LLC | 2.47%787.6K shares |
Candriam S.C.A. | 2.35%749.59K shares |
CITADEL ADVISORS LLC | 2.28%728.56K shares |
RTW INVESTMENTS, LP | 2.18%696.57K shares |
Stonepine Capital Management, LLC | 2.07%660K shares |
GEODE CAPITAL MANAGEMENT, LLC | 2.00%639.54K shares |
PRICE T ROWE ASSOCIATES INC /MD/ | 1.90%607.66K shares |
MARSHALL WACE, LLP | 1.83%585.58K shares |
BRAIDWELL LP | 1.83%584.41K shares |
Point72 Asset Management, L.P. | 1.74%556.76K shares |
Velan Capital Investment Management LP | 1.72%549.99K shares |
ADAGE CAPITAL PARTNERS GP, L.L.C. | 1.69%540.13K shares |
Woodline Partners LP | 1.66%531.25K shares |
STATE STREET CORP | 1.60%510.81K shares |
Percentages use 31.95M shares of this listed class outstanding on Jun 30, 2026.
Gray completes the 100% scale. Reported positions may overlap; holders have different reporting dates.
| Transaction | Insider | Type | Shares | Price | Value | Owned after |
|---|---|---|---|---|---|---|
| Dec 9, 2025Form 4 | Rich StuartChief Medical Officer | BuyCommon Stock | 2.5K | $10.22 | $25.6K | 5.3K |
| Dec 8, 2025Form 4 | Rich StuartChief Medical Officer | BuyCommon Stock · indirect | 2.5K | $10.10 | $25.3K | 5.0K |
| Dec 4, 2025Form 4 | Rich StuartChief Medical Officer | BuyCommon Stock · indirect | 2.5K | $9.20 | $23.0K | 2.5K |
| Dec 3, 2025Form 4 | Rich StuartChief Medical Officer | BuyCommon Stock | 1.5K | $9.08 | $13.6K | 2.8K |
| Dec 2, 2025Form 4 | Rich StuartChief Medical Officer | BuyCommon Stock | 1.0K | $9.01 | $9.0K | 1.3K |