Revenue
2013
2014
2015
2016
2017
2018
2019
2020
2021
2022
2023
2024
2025
| 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | $70.8M | $302,000 | $314,000 | $1.8M | $3.0M | $1.1M | $4.5M | $8.4M | $4.0M | $3.5M | $5.7M | $6.5M | $5.5M |
| Gross profit | — | — | — | — | — | — | — | — | — | $929,000 | $3.2M | $3.1M | $2.7M |
| Gross margin | — | — | — | — | — | — | — | — | — | 26.72% | 56.68% | 48.09% | 49.41% |
| Research & development | $338.9M | $238.3M | $159.8M | $100.9M | $56.9M | $28.3M | $34.8M | $30.4M | $19.6M | $13.7M | $1.0M | $347,000 | $225,000 |
| Operating expenses | $434.2M | $299.3M | $254.8M | $136.1M | $82.7M | $111.4M | $46.4M | $41.5M | $30.5M | $20.5M | $13.7M | $11.2M | $4.5M |
| Operating income | −$363.4M | −$299.0M | −$254.4M | −$134.3M | −$79.7M | −$110.4M | −$42.0M | −$33.1M | −$26.5M | −$17.0M | −$11.2M | −$6.9M | −$197,000 |
| Operating margin | −512.91% | −99,018.21% | −81,035.03% | −7,579.23% | −2,690.79% | −10,512.38% | −941.02% | −394.51% | −662.80% | −488.55% | −196.06% | −105.91% | −3.59% |
| EBITDA | −$362.9M | −$298.5M | −$253.9M | −$134.0M | −$79.6M | −$110.1M | −$41.7M | −$32.8M | −$26.2M | −$16.6M | −$11.0M | −$6.7M | −$49,000 |
| EBITDA margin | −512.27% | −98,839.40% | −80,868.79% | −7,564.84% | −2,686.74% | −10,489.62% | −934.57% | −391.16% | −655.11% | −478.75% | −192.83% | −103.69% | −0.89% |
| Net income | −$342.6M | −$269.9M | −$237.7M | −$129.9M | −$79.4M | −$110.7M | −$41.9M | −$32.7M | −$26.5M | −$17.3M | −$11.3M | −$7.9M | −$2.2M |
| Net profit margin | −483.57% | −89,387.09% | −75,711.46% | −7,329.23% | −2,680.16% | −10,544.29% | −938.65% | −389.97% | −662.30% | −496.81% | −198.53% | −121.68% | −39.34% |
| Basic EPSper basic share | -$3.32 | -$3.07 | -$5.31 | -$4.05 | -$6.66 | -$31.13 | -$20.04 | -$16.50 | -$20.70 | -$423.15 | -$315.30 | -$787.50 | -$2,751.75 |
| Diluted EPSper diluted share | -$3.32 | -$3.07 | -$5.31 | -$4.05 | -$6.66 | -$31.13 | -$20.04 | -$16.50 | -$20.70 | -$423.15 | -$315.30 | -$787.50 | -$2,751.75 |
Reported shareholders
| Holder | % owned |
|---|---|
FMR LLC | 14.66%16.6M shares |
BlackRock, Inc. | 7.55%8.55M shares |
Bellevue Group AG | 5.94%6.73M shares |
Paradigm Biocapital Advisors LP | 5.94%6.72M shares |
Kynam Capital Management, LP | 5.70%6.45M shares |
STATE STREET CORP | 5.41%6.12M shares |
PRICE T ROWE ASSOCIATES INC /MD/ | 5.08%5.75M shares |
Fairmount Funds Management LLC | 4.50%5.09M shares |
VANGUARD CAPITAL MANAGEMENT LLC | 4.04%4.58M shares |
Deep Track Capital, LP | 3.17%3.59M shares |
Venrock Adviser, LLC | 2.88%3.26M shares |
WELLINGTON MANAGEMENT GROUP LLP | 2.76%3.13M shares |
VANGUARD PORTFOLIO MANAGEMENT LLC | 2.43%2.75M shares |
GEODE CAPITAL MANAGEMENT, LLC | 2.21%2.5M shares |
Avoro Capital Advisors LLC | 2.21%2.5M shares |
BAKER BROS. ADVISORS LP | 2.10%2.38M shares |
Point72 Asset Management, L.P. | 2.07%2.34M shares |
Caligan Partners LP | 1.94%2.19M shares |
NOVO HOLDINGS A/S | 1.89%2.14M shares |
TANG CAPITAL MANAGEMENT LLC | 1.58%1.79M shares |
Percentages use 113.24M shares of this listed class outstanding on Jun 30, 2026.
Gray completes the 100% scale. Reported positions may overlap; holders have different reporting dates.
| Transaction | Insider | Type | Shares | Price | Value | Owned after |
|---|---|---|---|---|---|---|
| May 11, 2026Form 4 | Fairmount Healthcare Fund II L.P. +2Director,TenPercentOwner | BuyCommon Stock · indirect | 1.18M | $17.00 | $20.00M | 5.09M |
| Dec 31, 2025Form 4 | Tousignant JenniferChief Legal Officer | SellCommon Stock | 2.3K | $31.16 | $70.8K | 0 |
| Oct 23, 2025Form 4 | Fairmount Healthcare Fund II GP LLC +2Director,TenPercentOwner | BuyCommon Stock · indirect | 454.5K | $22.00 | $10.00M | 3.91M |
| Sep 27, 2024Form 4 | Beetham Thomas W.Chief Operating Officer | BuyCommon Stock | 5.0K | $23.41 | $117.0K | 6.0K |
| Sep 27, 2024Form 4 | Mahoney Stephen F.President and CEO | BuyCommon Stock | 21.4K | $23.33 | $499.3K | 21.4K |