Revenue
2018
2019
2020
2021
2022
2023
2024
2025
| 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | $457.2M | $397.6M | $266.7M | $212.7M | $144.1M | $49.0M | $13.0M | $129,000 | — | — | — |
| Gross profit | $266.7M | $250.5M | $170.9M | $138.7M | $91.9M | $32.2M | $9.2M | $85,862 | — | — | — |
| Gross margin | 58.33% | 63.00% | 64.08% | 65.20% | 63.75% | 65.82% | 71.13% | 66.56% | — | — | — |
| Research & development | $220.9M | $234.5M | $265.9M | $286.4M | $573.3M | $222.7M | $142.2M | $120.3M | $39.3M | $32.1M | $13.6M |
| Operating expenses | $496.1M | $532.6M | $537.5M | $543.0M | $791.9M | $334.0M | $212.4M | $141.9M | — | — | — |
| Operating income | −$229.4M | −$282.1M | −$366.6M | −$404.4M | −$700.1M | −$301.8M | −$203.2M | −$141.8M | −$51.4M | −$38.5M | −$16.3M |
| Operating margin | −50.18% | −70.95% | −137.44% | −190.13% | −485.80% | −616.45% | −1,564.85% | −109,897.67% | — | — | — |
| EBITDA | −$214.4M | −$270.3M | −$357.5M | −$396.1M | −$693.6M | −$297.2M | −$199.4M | −$140.1M | −$50.8M | −$38.3M | −$16.2M |
| EBITDA margin | −46.90% | −67.97% | −134.05% | −186.26% | −481.30% | −606.97% | −1,535.85% | −108,618.60% | — | — | — |
| Net income | −$175.5M | −$257.1M | −$334.6M | −$443.3M | −$704.5M | −$268.9M | −$195.1M | −$139.1M | −$50.4M | −$37.5M | −$18.0M |
| Net profit margin | −38.40% | −64.66% | −125.46% | −208.44% | −488.86% | −549.26% | −1,502.28% | −107,810.08% | — | — | — |
| Basic EPSper basic share | -$0.16 | -$0.26 | -$0.35 | -$0.46 | -$0.76 | -$0.35 | -$0.30 | -$0.26 | -$0.23 | -$0.40 | -$0.21 |
| Diluted EPSper diluted share | -$0.16 | -$0.26 | -$0.35 | -$0.46 | -$0.76 | -$0.35 | -$0.30 | -$0.26 | -$0.23 | -$0.40 | -$0.21 |
Reported shareholders
Reported holdings Number of shares
| Holder | Shares held |
|---|---|
RTW INVESTMENTS, LP | 6.57M |
TCG Crossover Management, LLC | 6.14M |
RA CAPITAL MANAGEMENT, L.P. | 5.74M |
ADAR1 Capital Management, LLC | 3.37M |
FMR LLC | 2.82M |
GOLDMAN SACHS GROUP INC | 2.32M |
Woodline Partners LP | 2.21M |
Frazier Life Sciences Management, L.P. | 1.9M |
BAMCO INC /NY/ | 1.62M |
TWO SIGMA INVESTMENTS, LP | 1.3M |
CITADEL ADVISORS LLC | 1.28M |
Rock Springs Capital Management LP | 814.71K |
BlackRock, Inc. | 664.46K |
C WorldWide Group Holding A/S | 510K |
JANE STREET GROUP, LLC | 476.54K |
B Group, Inc. | 450.65K |
Nantahala Capital Management, LLC | 400K |
SCHRODER INVESTMENT MANAGEMENT GROUP | 393.17K |
NAN FUNG TRINITY (HK) LTD | 346.47K |
Aberdeen Group plc | 311.29K |
Bars compare reported share counts. A matching total for this share class and reporting period is unavailable, so percentages are not shown.
| Transaction | Insider | Type | Shares | Price | Value | Owned after |
|---|---|---|---|---|---|---|
| Jun 26, 2026Form 4 | Edmondson Frazor Titus IIIChief Legal Officer | SellAmerican Depositary Shares | 4.1K | $17.46 | $71.6K | 30.3K |
| Jun 26, 2026Form 4 | Du YingChairperson & CEO | SellAmerican Depositary Shares | 24.5K | $17.46 | $428.5K | 1.19M |
| Jun 26, 2026Form 4 | Chen YajingChief Financial Officer | SellAmerican Depositary Shares | 2.3K | $17.46 | $39.5K | 35.7K |
| Jun 22, 2026Form 4 · 10b5-1 | Lis WilliamDirector | SellAmerican Depositary Shares | 7.0K | $18.09 | $127.4K | 50.4K |
| May 18, 2026Form 4 · 10b5-1 | Du YingChairperson & CEO | SellAmerican Depositary Shares | 50.0K | $19.00 | $950.0K | 1.12M |