Revenue
2009
2010
2011
2012
2013
2014
2015
2016
2017
2018
2019
2020
2021
2022
2023
2024
2025
| 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | $1.07B | $957.8M | $726.4M | $517.2M | $484.1M | $441.8M | $339.1M | $223.8M | $124.9M | $17.3M | $61,000 | $120,000 | $1.1M | $4.9M | $2.1M | $42.1M | $6.4M |
| Gross profit | $982.5M | $876.0M | $684.8M | $507.1M | $473.3M | $431.5M | $327.7M | $211.4M | $115.8M | $14.3M | — | — | — | — | — | — | — |
| Gross margin | 91.69% | 91.46% | 94.27% | 98.03% | 97.76% | 97.69% | 96.65% | 94.47% | 92.73% | 82.23% | — | — | — | — | — | — | — |
| Research & development | $328.8M | $303.2M | $351.6M | $361.6M | $239.4M | $319.1M | $240.4M | $187.2M | $149.2M | $99.3M | $73.9M | $60.6M | $26.7M | $18.8M | $17.3M | $20.6M | $41.6M |
| Operating expenses | $966.7M | $727.0M | $799.8M | $740.8M | $654.6M | $728.3M | $585.6M | $471.3M | $417.3M | $290.1M | $164.7M | $93.3M | $39.4M | $25.8M | $24.9M | $27.0M | $51.9M |
| Operating income | $104.8M | $230.8M | −$73.4M | −$223.6M | −$170.4M | −$286.6M | −$246.5M | −$247.4M | −$292.4M | −$272.8M | −$164.6M | −$93.2M | −$38.3M | −$20.9M | −$22.9M | $15.1M | −$45.5M |
| Operating margin | 9.78% | 24.10% | −10.10% | −43.23% | −35.20% | −64.87% | −72.71% | −110.56% | −234.11% | −1,574.14% | −269,855.74% | −77,691.67% | −3,344.72% | −425.64% | −1,105.56% | 35.82% | −710.55% |
| EBITDA | $116.6M | $246.7M | −$67.8M | −$221.6M | −$167.1M | −$283.7M | −$243.8M | −$244.4M | −$289.7M | −$271.0M | −$164.0M | −$93.0M | −$38.2M | −$20.8M | −$22.6M | $15.7M | −$44.4M |
| EBITDA margin | 10.88% | 25.75% | −9.34% | −42.84% | −34.51% | −64.21% | −71.90% | −109.22% | −231.94% | −1,563.60% | −268,795.08% | −77,520.00% | −3,337.82% | −423.42% | −1,091.78% | 37.26% | −693.19% |
| Net income | $391.0M | $226.5M | −$61.3M | −$216.0M | −$167.9M | −$281.6M | −$235.3M | −$245.2M | −$289.4M | −$271.4M | −$164.4M | −$92.5M | −$37.9M | −$20.8M | −$22.8M | $15.1M | −$45.1M |
| Net profit margin | 36.49% | 23.64% | −8.44% | −41.76% | −34.67% | −63.74% | −69.38% | −109.56% | −231.71% | −1,565.94% | −269,578.69% | −77,062.50% | −3,314.24% | −424.88% | −1,101.35% | 35.93% | −705.50% |
| Basic EPSper basic share | $2.32 | $1.37 | -$0.37 | -$1.34 | -$1.05 | -$1.79 | -$1.60 | -$1.94 | -$2.36 | -$2.34 | -$1.63 | -$0.95 | -$0.44 | -$0.38 | -$0.44 | $0.39 | -$1.20 |
| Diluted EPSper diluted share | $2.30 | $1.36 | -$0.37 | -$1.34 | -$1.05 | -$1.79 | -$1.60 | -$1.94 | -$2.36 | -$2.34 | -$1.63 | -$0.95 | -$0.44 | -$0.38 | -$0.44 | $0.39 | -$1.20 |
Reported shareholders
| Holder | % owned |
|---|---|
BAKER BROS. ADVISORS LP | 24.93%42.91M shares |
BlackRock, Inc. | 13.08%22.52M shares |
STATE STREET CORP | 5.27%9.08M shares |
VANGUARD PORTFOLIO MANAGEMENT LLC | 5.13%8.84M shares |
RTW INVESTMENTS, LP | 4.15%7.14M shares |
VANGUARD CAPITAL MANAGEMENT LLC | 3.35%5.76M shares |
DIMENSIONAL FUND ADVISORS LP | 2.15%3.69M shares |
GEODE CAPITAL MANAGEMENT, LLC | 1.95%3.36M shares |
Palo Alto Investors LP | 1.66%2.86M shares |
GOLDMAN SACHS GROUP INC | 1.50%2.58M shares |
Qube Research & Technologies Ltd | 1.42%2.45M shares |
Point72 Asset Management, L.P. | 1.41%2.43M shares |
CITADEL ADVISORS LLC | 1.27%2.18M shares |
Pictet Asset Management Holding SA | 1.15%1.98M shares |
ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 1.14%1.97M shares |
MARSHALL WACE, LLP | 1.03%1.76M shares |
D. E. Shaw & Co., Inc. | 0.99%1.7M shares |
BRAIDWELL LP | 0.96%1.65M shares |
NORGES BANK | 0.94%1.62M shares |
Frazier Life Sciences Management, L.P. | 0.84%1.44M shares |
Percentages use 172.13M shares of this listed class outstanding on Jun 30, 2026.
Gray completes the 100% scale. Reported positions may overlap; holders have different reporting dates.
| Transaction | Insider | Type | Shares | Price | Value | Owned after |
|---|---|---|---|---|---|---|
| Jun 26, 2026Form 4 · 10b5-1 | Kihara JamesPRINCIPAL ACCOUNTING OFFICER | SellCommon Stock | 11.4K | $26.08 | $297.9K | 13.1K |
| May 26, 2026Form 4 | Kihara JamesPRINCIPAL ACCOUNTING OFFICER | SellCommon Stock | 5.4K | $21.18 | $114.4K | 24.5K |
| May 4, 2026Form 4 | Schneyer Mark C.EVP, CHIEF FINANCIAL OFFICER | SellCommon Stock | 3.5K | $21.79 | $76.4K | 66.1K |
| May 4, 2026Form 4 | Kihara JamesPRINCIPAL ACCOUNTING OFFICER | SellCommon Stock | 1.3K | $21.79 | $29.0K | 29.1K |
| Apr 7, 2026Form 4 | Schneyer Mark C.EVP, CHIEF FINANCIAL OFFICER | SellCommon Stock | 2.7K | $22.20 | $60.1K | 62.8K |