Revenue
2011
2012
2013
2014
2015
2016
2017
2018
2019
2020
2021
2022
2023
2024
2025
| 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | $829.4M | $3.6M | $240.7M | $243.2M | $138.3M | $88.0M | $168.8M | $16.1M | $31.4M | $158,333 | $382,000 | $175,000 | $290,266 | $146,875 | $296,139 | — | — | — | — | — | — | — | — |
| Research & development | $607.2M | $505.9M | $353.2M | $297.3M | $206.3M | $128.9M | $81.0M | $53.0M | $50.9M | $62.1M | $47.3M | $23.1M | $8.7M | $5.4M | $3.3M | $529,601 | — | — | — | — | — | — | — |
| Operating expenses | $731.1M | $604.6M | $445.7M | $421.7M | $287.3M | $181.2M | $107.6M | $72.1M | $68.4M | $81.9M | $96.4M | $53.5M | $24.9M | $21.2M | $10.1M | $5.8M | — | — | — | — | — | — | — |
| Operating income | $98.3M | −$601.1M | −$205.0M | −$178.5M | −$149.0M | −$93.2M | $61.2M | −$55.9M | −$37.0M | −$81.7M | −$96.0M | −$53.3M | −$24.6M | −$21.1M | −$9.8M | −$5.8M | — | — | — | — | — | — | — |
| Operating margin | 11.86% | −16,927.06% | −85.16% | −73.39% | −107.77% | −105.87% | 36.25% | −346.52% | −117.79% | −51,627.09% | −25,124.08% | −30,443.59% | −8,471.29% | −14,358.61% | −3,319.48% | — | — | — | — | — | — | — | — |
| EBITDA | $120.5M | −$584.2M | −$194.3M | −$169.8M | −$142.4M | −$89.0M | $63.9M | −$52.9M | −$34.0M | −$78.5M | −$93.6M | −$51.9M | −$22.8M | −$19.3M | −$9.6M | −$5.6M | — | — | — | — | — | — | — |
| EBITDA margin | 14.53% | −16,451.14% | −80.71% | −69.81% | −103.00% | −101.10% | 37.85% | −327.94% | −108.27% | −49,568.11% | −24,512.50% | −29,674.65% | −7,867.91% | −13,167.82% | −3,228.99% | — | — | — | — | — | — | — | — |
| Net income | −$1.6M | −$599.5M | −$205.3M | −$176.1M | −$140.8M | −$84.6M | $68.0M | −$54.5M | −$34.4M | −$81.7M | −$91.9M | −$58.6M | −$31.1M | −$21.1M | −$3.1M | −$5.8M | −$19.3M | −$27.2M | −$30.7M | −$20.0M | −$6.7M | −$751,255 | −$95,238 |
| Net profit margin | −0.20% | −16,882.37% | −85.27% | −72.39% | −101.85% | −96.09% | 40.27% | −337.32% | −109.46% | −51,614.64% | −24,068.29% | −33,502.97% | −10,729.22% | −14,383.61% | −1,056.56% | — | — | — | — | — | — | — | — |
| Basic EPSper basic share | -$0.01 | -$5.00 | -$1.92 | -$1.67 | -$1.36 | -$0.84 | $0.72 | -$0.65 | -$0.47 | -$1.34 | -$1.60 | -$1.25 | -$1.30 | -$19.00 | -$4.40 | -$9.00 | — | — | — | — | — | — | — |
| Diluted EPSper diluted share | -$0.01 | -$5.00 | -$1.92 | -$1.67 | -$1.36 | -$0.84 | $0.69 | -$0.65 | -$0.47 | -$1.34 | -$1.60 | -$1.25 | -$1.30 | -$1.90 | -$4.00 | -$9.00 | — | — | — | — | — | — | — |
Reported shareholders
| Holder | % owned |
|---|---|
BlackRock, Inc. | 10.51%14.83M shares |
Avoro Capital Advisors LLC | 8.05%11.36M shares |
FMR LLC | 5.70%8.04M shares |
VANGUARD PORTFOLIO MANAGEMENT LLC | 4.50%6.35M shares |
VANGUARD CAPITAL MANAGEMENT LLC | 4.33%6.11M shares |
STATE STREET CORP | 4.03%5.69M shares |
NORGES BANK | 2.76%3.9M shares |
Invesco Ltd. | 2.75%3.88M shares |
Anzalone Christopher Richard | ≈2.69%3.79M shares |
GEODE CAPITAL MANAGEMENT, LLC | 2.50%3.53M shares |
FRED ALGER MANAGEMENT, LLC | 2.34%3.3M shares |
BAKER BROS. ADVISORS LP | 1.41%1.99M shares |
Siren, L.L.C. | 1.22%1.72M shares |
Vestal Point Capital, LP | 1.12%1.58M shares |
DEERFIELD MANAGEMENT COMPANY, L.P. | 0.98%1.39M shares |
FIRST TRUST ADVISORS LP | 0.96%1.35M shares |
Driehaus Capital Management LLC | 0.96%1.35M shares |
Jupiter Topco LLC | 0.87%1.22M shares |
NORTHERN TRUST CORP | 0.85%1.19M shares |
DIMENSIONAL FUND ADVISORS LP | 0.84%1.18M shares |
Percentages use 141.14M shares of this listed class outstanding on Jun 30, 2026. ≈ compares the latest reported holding with a share total from a different date; it is not a confirmed current stake.
Gray completes the 100% scale. Reported positions may overlap; holders have different reporting dates.
| Transaction | Insider | Type | Shares | Price | Value | Owned after |
|---|---|---|---|---|---|---|
| May 12, 2026Form 4 · 10b5-1 | Lu HongboDirector | SellCommon Stock | 3.0K | $76.88 | $228.3K | 52.0K |
| Apr 23, 2026Form 4 · 10b5-1 | Hamilton James CChief Medical Officer | SellCommon Stock | 10.0K | $75.00 | $750.0K | 227.0K |
| Apr 22, 2026Form 4 · 10b5-1 | Apel Daniel JosephChief Financial Officer | SellCommon Stock | 8.7K | $71.92 | $627.9K | 162.9K |
| Apr 22, 2026Form 4 · 10b5-1 | Apel Daniel JosephChief Financial Officer | SellCommon Stock | 1.2K | $70.45 | $81.5K | 171.6K |
| Apr 22, 2026Form 4 · 10b5-1 | Apel Daniel JosephChief Financial Officer | SellCommon Stock | 3.2K | $70.11 | $224.9K | 172.8K |