Revenue
2011
2012
2013
2014
2015
2016
2017
2018
2019
2020
2021
2022
2023
2024
2025
| 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | $0 | $22.3M | $25.2M | $2.6M | $244,898 | $310,250 | $1.0M | $1.7M | $2.7M | $4.0M | $5.5M | $4.8M | $503,233 | $195,500 | $1.4M | — | — | — | — | — |
| Research & development | $84.5M | $50.0M | $36.4M | $21.8M | $13.6M | $8.5M | $5.1M | $12.1M | $10.8M | $16.0M | $13.8M | $7.8M | $5.2M | $2.6M | $4.1M | $4.1M | — | — | — | — |
| Operating expenses | $108.1M | $64.8M | $49.3M | $32.2M | $21.2M | $14.0M | $8.7M | $17.0M | $15.5M | $21.0M | $18.1M | $10.8M | $7.4M | $4.0M | $6.3M | $6.3M | — | — | — | — |
| Operating income | −$108.1M | −$42.6M | −$24.1M | −$29.7M | −$20.9M | −$13.7M | −$7.7M | −$15.3M | −$12.9M | −$17.0M | −$12.6M | −$6.0M | −$6.9M | −$2.1M | −$4.9M | −$6.3M | — | — | — | — |
| Operating margin | — | −191.12% | −95.63% | −1,163.93% | −8,549.86% | −4,412.56% | −769.52% | −917.04% | −482.40% | −424.56% | −228.57% | −125.72% | −1,371.71% | −1,074.19% | −361.70% | — | — | — | — | — |
| EBITDA | −$106.3M | −$41.1M | −$23.0M | −$29.2M | −$20.7M | −$13.5M | −$7.6M | −$15.2M | −$12.7M | −$16.9M | −$12.5M | −$6.0M | −$6.9M | −$2.1M | −$4.9M | −$6.3M | — | — | — | — |
| EBITDA margin | — | −184.72% | −91.39% | −1,143.04% | −8,449.54% | −4,366.18% | −752.41% | −907.61% | −476.99% | −421.42% | −226.56% | −124.85% | −1,366.36% | −1,063.79% | −361.14% | — | — | — | — | — |
| Net income | −$105.0M | −$40.5M | −$22.3M | −$29.0M | −$20.0M | −$13.7M | −$7.6M | −$15.2M | $2.4M | −$18.8M | −$12.9M | −$6.2M | −$8.9M | −$2.1M | −$1.1M | −$1.1M | −$148,970 | −$630,859 | −$979,076 | −$1.2M |
| Net profit margin | — | −181.71% | −88.52% | −1,137.37% | −8,175.86% | −4,401.94% | −760.36% | −908.91% | 91.19% | −470.33% | −233.02% | −129.87% | −1,766.96% | −1,059.47% | −84.85% | — | — | — | — | — |
| Basic EPSper basic share | -$2.26 | -$1.15 | -$0.83 | -$1.18 | -$0.87 | -$0.88 | -$2.06 | -$5.17 | $10.00 | -$101.00 | -$81.00 | -$53.00 | -$85.00 | -$21.00 | -$13.00 | -$19.00 | — | — | — | — |
| Diluted EPSper diluted share | -$2.26 | -$1.15 | -$0.83 | -$1.18 | -$0.87 | -$0.88 | -$2.06 | -$52.00 | $9.00 | -$101.00 | -$81.00 | -$53.00 | -$85.00 | -$21.00 | -$13.00 | -$19.00 | — | — | — | — |
Reported shareholders
| Holder | % owned |
|---|---|
Nippon Shinyaku Co Ltd | ≈12.20%7.09M shares |
BlackRock, Inc. | 7.13%4.15M shares |
TANG CAPITAL MANAGEMENT LLC | 7.06%4.1M shares |
MONTANOVA CAPITAL, LLC | 7.04%4.09M shares |
STATE STREET CORP | 5.85%3.4M shares |
VANGUARD CAPITAL MANAGEMENT LLC | 3.95%2.3M shares |
GOLDMAN SACHS GROUP INC | 2.72%1.58M shares |
RA CAPITAL MANAGEMENT, L.P. | 2.59%1.51M shares |
Boxer Capital Management, LLC | 2.40%1.4M shares |
GEODE CAPITAL MANAGEMENT, LLC | 2.36%1.37M shares |
FMR LLC | 1.96%1.14M shares |
CITADEL ADVISORS LLC | 1.40%814.44K shares |
MERCER GLOBAL ADVISORS INC /ADV | 1.38%802.73K shares |
Soleus Capital Management, L.P. | 1.31%761.74K shares |
MORGAN STANLEY | 1.18%684.52K shares |
VANGUARD PORTFOLIO MANAGEMENT LLC | 1.09%636.09K shares |
UBS Group AG | 1.07%619.66K shares |
DG Capital Management, LLC | 1.05%611.6K shares |
Ikarian Capital, LLC | 1.04%604.22K shares |
NORTHERN TRUST CORP | 0.87%503.53K shares |
Percentages use 58.11M shares of this listed class outstanding on Jun 30, 2026. ≈ compares the latest reported holding with a share total from a different date; it is not a confirmed current stake.
Gray completes the 100% scale. Reported positions may overlap; holders have different reporting dates.
| Transaction | Insider | Type | Shares | Price | Value | Owned after |
|---|---|---|---|---|---|---|
| Jun 25, 2026Form 4 | Bergmann AnthonyCHIEF FINANCIAL OFFICER | SellCommon Stock | 24.1K | $30.38 | $732.2K | 11.2K |
| Jun 25, 2026Form 4 | Krasney KarenEVP, GENERAL COUNSEL | SellCommon Stock | 24.1K | $30.38 | $732.2K | 30.5K |
| Jun 24, 2026Form 4 | Bergmann AnthonyCHIEF FINANCIAL OFFICER | SellCommon Stock | 400 | $30.00 | $12.0K | 11.2K |
| Jun 24, 2026Form 4 | Krasney KarenEVP, GENERAL COUNSEL | SellCommon Stock | 400 | $30.00 | $12.0K | 30.5K |
| Jun 22, 2026Form 4 | Bergmann AnthonyCHIEF FINANCIAL OFFICER | SellCommon Stock | 500 | $30.00 | $15.0K | 11.2K |