Revenue
2012
2013
2014
2015
2016
2020
2021
2022
2023
2025
| 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | $10.8M | — | $10,000 | $75,000 | $1.2M | $10.2M | — | — | — | $18,500 | $20.1M | $15.0M | $4.0M | $15.3M |
| Research & development | $138.1M | $14.3M | $20.1M | $28.4M | $47.5M | $44.9M | $47.0M | $40.1M | $24.1M | $23.3M | $25.1M | $19.6M | $11.7M | $9.4M |
| Operating expenses | $163.5M | $40.0M | $39.3M | $47.5M | $64.6M | $61.7M | $61.4M | $51.5M | $33.9M | $31.9M | $32.9M | $26.2M | $14.6M | $11.6M |
| Operating income | −$152.6M | −$40.0M | −$39.3M | −$47.4M | −$63.4M | −$51.5M | −$61.4M | −$51.5M | −$33.9M | −$31.9M | −$12.8M | −$11.1M | −$10.6M | $3.6M |
| Operating margin | −1,407.52% | — | −392,752.93% | −63,204.43% | −5,470.69% | −506.84% | — | — | — | −172,505.32% | −63.70% | −74.13% | −265.65% | 23.82% |
| EBITDA | −$152.5M | −$40.0M | −$39.1M | −$47.2M | −$63.2M | −$51.2M | −$61.1M | −$51.2M | −$33.7M | −$31.7M | −$12.6M | −$11.0M | −$10.5M | $3.7M |
| EBITDA margin | −1,406.75% | — | −391,219.92% | −62,928.24% | −5,447.87% | −504.17% | — | — | — | −171,475.38% | −62.74% | −73.08% | −262.32% | 24.48% |
| Net income | −$153.9M | −$37.9M | −$36.9M | −$46.7M | −$63.4M | −$51.0M | −$57.9M | −$48.3M | −$33.3M | −$31.8M | −$12.8M | −$11.1M | −$10.6M | $3.7M |
| Net profit margin | −1,419.61% | — | −368,994.20% | −62,251.74% | −5,468.98% | −502.09% | — | — | — | −171,945.07% | −63.62% | −74.01% | −265.63% | 23.96% |
| Basic EPSper basic share | -$12.81 | -$3,717.00 | -$3,654.00 | -$5,607.00 | -$7,749.00 | -$7,056.00 | -$8,442.00 | -$7,434.00 | -$7,119.00 | -$9,450.00 | -$4,221.00 | -$3,780.00 | -$55,881.00 | $24,759.00 |
| Diluted EPSper diluted share | -$12.81 | -$3,717.00 | -$3,654.00 | -$5,607.00 | -$7,749.00 | -$7,056.00 | -$8,442.00 | -$7,434.00 | -$7,119.00 | -$9,450.00 | -$4,221.00 | -$3,780.00 | -$55,881.00 | $2,079.00 |
Reported shareholders
Reported holdings Number of shares
| Holder | Shares held |
|---|---|
Siren, L.L.C. / DEBBANE RAYMOND / Invus Public Equities Advisors, LLC / Invus Global Management, LLC / Invus Public Equities, L.P. | 6.32M |
FMR LLC | 4.13M |
BVF INC/IL | 2.75M |
Fairmount Funds Management LLC | 2.75M |
Venrock Adviser, LLC | 2.13M |
Logos Global Management LP | 1.9M |
FCPM III SERVICES B.V. | 1.68M |
Balyasny Asset Management L.P. | 1.66M |
Vestal Point Capital, LP | 1.63M |
Opaleye Management Inc. | 1.32M |
BlackRock, Inc. | 1.27M |
TANG CAPITAL MANAGEMENT LLC | 1.16M |
VANGUARD CAPITAL MANAGEMENT LLC | 767.76K |
MILLENNIUM MANAGEMENT LLC | 403.86K |
GEODE CAPITAL MANAGEMENT, LLC | 384.58K |
JENNISON ASSOCIATES LLC | 378.51K |
RTW INVESTMENTS, LP | 372.86K |
NEXTBio Capital Management LP | 372.86K |
Remedium Capital Partners, LLC | 361.25K |
STATE STREET CORP | 315.59K |
Bars compare reported share counts. A matching total for this share class and reporting period is unavailable, so percentages are not shown.
| Transaction | Insider | Type | Shares | Price | Value | Owned after |
|---|---|---|---|---|---|---|
| Jun 22, 2026Form 4 · 10b5-1 | Lynch RyanSee Remarks | SellOrdinary Shares | 465 | $17.99 | $8.4K | 13.9K |
| Jun 22, 2026Form 4 · 10b5-1 | Pinkas JanChief Scientific Officer | SellOrdinary Shares | 1.3K | $17.99 | $23.2K | 22.2K |
| Jun 22, 2026Form 4 · 10b5-1 | Scalzo Richard WilliamChief Financial Officer | SellOrdinary Shares | 1.1K | $17.99 | $20.0K | 20.3K |
| Jun 22, 2026Form 4 · 10b5-1 | Bispham Barbara HarlinSee Remarks | SellOrdinary Shares | 1.2K | $17.99 | $21.9K | 19.3K |
| Jun 22, 2026Form 4 · 10b5-1 | Im Ellie EunkyungChief Medical Officer | SellOrdinary Shares | 1.2K | $17.99 | $21.9K | 22.1K |