Revenue
2009
2010
2011
2012
2013
2014
2015
2016
2017
2018
2019
2020
2021
2022
2023
2024
2025
| 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | $70.4M | $59.3M | $70.1M | $138.6M | $104.8M | $69.1M | $68.5M | $60.6M | $50.0M | $48.8M | $41.8M | $35.3M | $31.9M | $88.3M | $123.9M | $107.1M | $82.9M |
| Gross profit | $61.0M | $43.1M | $57.3M | $100.6M | $82.5M | $55.3M | $52.8M | $48.0M | $35.7M | $39.1M | $35.2M | $25.6M | $17.4M | $57.7M | $82.1M | $79.1M | $66.2M |
| Gross margin | 86.73% | 72.55% | 81.74% | 72.56% | 78.80% | 80.10% | 77.17% | 79.17% | 71.36% | 80.03% | 84.25% | 72.45% | 54.41% | 65.29% | 66.27% | 73.87% | 79.88% |
| Research & development | $52.3M | $46.3M | $58.9M | $80.1M | $55.9M | $44.2M | $33.9M | $30.0M | $29.7M | $22.2M | $20.7M | $22.8M | $31.6M | $56.8M | $61.0M | $52.4M | $54.7M |
| Operating expenses | $112.1M | $117.9M | $138.2M | $173.5M | $127.5M | $93.0M | $81.0M | $71.9M | $73.0M | $57.4M | $49.6M | $54.4M | $73.1M | $118.8M | $139.8M | $114.2M | $101.3M |
| Operating income | −$41.7M | −$58.5M | −$68.1M | −$34.9M | −$22.7M | −$23.9M | −$12.5M | −$11.3M | −$23.0M | −$8.6M | −$7.8M | −$19.1M | −$41.1M | −$30.5M | −$15.9M | −$7.1M | −$18.4M |
| Operating margin | −59.30% | −98.61% | −97.04% | −25.17% | −21.67% | −34.64% | −18.33% | −18.64% | −45.92% | −17.54% | −18.59% | −54.13% | −128.90% | −34.56% | −12.84% | −6.65% | −22.15% |
| EBITDA | −$36.5M | −$53.6M | −$62.6M | −$29.5M | −$19.5M | −$21.8M | −$10.8M | −$10.1M | −$21.9M | −$4.0M | — | — | — | — | — | — | — |
| EBITDA margin | −51.84% | −90.27% | −89.18% | −21.27% | −18.59% | −31.59% | −15.72% | −16.75% | −43.83% | −8.23% | — | — | — | — | — | — | — |
| Net income | −$44.0M | −$65.3M | −$76.2M | −$33.6M | −$21.3M | −$24.0M | −$11.9M | −$10.9M | −$23.0M | −$8.6M | −$7.6M | −$19.1M | −$41.3M | −$30.9M | −$16.6M | −$8.5M | −$20.3M |
| Net profit margin | −62.47% | −109.99% | −108.69% | −24.24% | −20.31% | −34.77% | −17.43% | −17.95% | −45.97% | −17.52% | −18.13% | −54.01% | −129.39% | −34.95% | −13.36% | −7.97% | −24.47% |
| Basic EPSper basic share | -$0.50 | -$0.89 | -$1.12 | -$0.51 | -$0.33 | -$0.40 | -$0.21 | -$0.21 | -$0.50 | -$0.21 | -$0.19 | -$0.50 | -$1.08 | -$0.84 | -$0.46 | -$0.35 | -$7.74 |
| Diluted EPSper diluted share | -$0.50 | -$0.89 | -$1.12 | -$0.51 | -$0.33 | -$0.40 | -$0.21 | -$0.21 | -$0.50 | -$0.21 | -$0.19 | -$0.50 | -$1.08 | -$0.84 | -$0.46 | -$0.35 | -$7.74 |
Reported shareholders
| Holder | % owned |
|---|---|
BlackRock, Inc. | 7.97%7.28M shares |
Nantahala Capital Management, LLC | 7.93%7.25M shares |
Opaleye Management Inc. | 7.42%6.79M shares |
Aberdeen Group plc | 7.41%6.77M shares |
MILLENNIUM MANAGEMENT LLC | 6.07%5.55M shares |
Telemark Asset Management, LLC | 4.21%3.85M shares |
AMERIPRISE FINANCIAL INC | 4.17%3.81M shares |
VANGUARD CAPITAL MANAGEMENT LLC | 3.96%3.62M shares |
Assenagon Asset Management S.A. | 2.80%2.56M shares |
GEODE CAPITAL MANAGEMENT, LLC | 2.37%2.16M shares |
STATE STREET CORP | 1.92%1.76M shares |
D. E. Shaw & Co., Inc. | 1.47%1.34M shares |
JACOBS LEVY EQUITY MANAGEMENT, INC | 1.46%1.33M shares |
VANGUARD PORTFOLIO MANAGEMENT LLC | 1.43%1.31M shares |
AQR CAPITAL MANAGEMENT LLC | 0.93%845.43K shares |
DILLY STEPHEN GEORGE | ≈0.80%727.05K shares |
TWO SIGMA INVESTMENTS, LP | 0.76%696.6K shares |
NORTHERN TRUST CORP | 0.75%682.94K shares |
FRANKLIN RESOURCES INC | 0.74%678.64K shares |
MORGAN STANLEY | 0.71%649.17K shares |
Percentages use 91.39M shares of this listed class outstanding on Jun 30, 2026. ≈ compares the latest reported holding with a share total from a different date; it is not a confirmed current stake.
Gray completes the 100% scale. Reported positions may overlap; holders have different reporting dates.
| Transaction | Insider | Type | Shares | Price | Value | Owned after |
|---|---|---|---|---|---|---|
| Jun 11, 2026Form 4 | De Vre RaymondDirector | SellCommon Stock | 2.6K | $2.37 | $6.2K | 84.8K |
| Feb 24, 2026Form 4 | Lutz StefanChief Scientific Officer | SellCommon Stock | 5.9K | $1.13 | $6.6K | 130.4K |
| Feb 6, 2026Form 4 | Lutz StefanChief Scientific Officer | SellCommon Stock | 2.5K | $1.31 | $3.3K | 136.3K |
| Feb 6, 2026Form 4 | Erbez GeorgiaSee Remarks | SellCommon Stock | 3.8K | $1.31 | $5.0K | 66.8K |
| Feb 6, 2026Form 4 | MOORE ALISONPresident and CEO | SellCommon Stock | 3.8K | $1.31 | $5.0K | 250.5K |