Revenue
2009
2010
2011
2012
2013
2014
2015
2016
2017
2018
2019
2020
2021
2022
2023
2024
2025
| 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1999 | 1998 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | $88.0M | $18.5M | $7.5M | $94.6M | $70.4M | $55.8M | $26.9M | $31.5M | $13.4M | $106.4M | $28.7M | $46.9M | $30.6M | $7.6M | $4.0M | $2.6M | $81.5M | — | — | — | — | — | — | — | — | — | — | — |
| Research & development | $416.0M | $339.4M | $330.1M | $240.8M | $159.9M | $97.0M | $86.1M | $89.1M | $90.3M | $59.9M | $46.4M | $44.4M | $49.5M | $35.6M | $37.2M | $38.0M | $39.8M | — | — | — | — | — | — | — | — | — | — | — |
| Operating expenses | $700.3M | $554.7M | $503.7M | $418.8M | $256.7M | $149.8M | $125.7M | $120.4M | $126.8M | $87.7M | $66.1M | $61.7M | $64.5M | $48.0M | $52.0M | $52.2M | $55.4M | — | — | — | — | — | — | — | — | — | — | — |
| Operating income | −$612.3M | −$536.2M | −$496.2M | −$324.2M | −$186.3M | −$93.9M | −$98.9M | −$88.9M | −$113.4M | $18.7M | −$37.4M | −$14.8M | −$33.9M | −$40.5M | −$48.0M | −$49.6M | $26.1M | — | — | — | — | — | — | — | — | — | — | — |
| Operating margin | −695.44% | −2,902.72% | −6,589.71% | −342.75% | −264.54% | −168.27% | −367.97% | −282.26% | −848.26% | 17.56% | −130.53% | −31.43% | −110.59% | −535.22% | −1,199.10% | −1,926.08% | 32.00% | — | — | — | — | — | — | — | — | — | — | — |
| EBITDA | −$602.1M | −$526.7M | −$484.3M | −$318.4M | −$184.0M | −$92.1M | −$97.6M | −$87.7M | −$111.5M | $19.4M | −$36.8M | −$14.3M | −$33.5M | −$39.9M | −$46.7M | −$47.7M | $28.1M | — | — | — | — | — | — | — | — | — | — | — |
| EBITDA margin | −683.94% | −2,851.13% | −6,431.78% | −336.61% | −261.31% | −164.99% | −363.16% | −278.33% | −833.90% | 18.26% | −128.47% | −30.39% | −109.18% | −527.40% | −1,166.68% | −1,852.35% | 34.48% | — | — | — | — | — | — | — | — | — | — | — |
| Net income | −$785.0M | −$589.5M | −$526.2M | −$389.0M | −$215.3M | −$127.3M | −$121.7M | −$106.3M | −$127.8M | $16.5M | −$37.5M | −$14.6M | −$33.7M | −$40.4M | −$47.9M | −$49.3M | $24.5M | −$56.4M | −$48.9M | −$57.1M | −$42.3M | −$37.2M | −$32.7M | −$23.1M | −$15.9M | −$13.1M | −$7.3M | −$2.0M |
| Net profit margin | −891.60% | −3,191.11% | −6,988.63% | −411.21% | −305.72% | −228.00% | −452.93% | −337.41% | −955.94% | 15.46% | −130.86% | −31.20% | −110.01% | −534.07% | −1,196.50% | −1,912.57% | 30.10% | — | — | — | — | — | — | — | — | — | — | — |
| Basic EPSper basic share | -$6.54 | -$5.26 | -$5.45 | -$4.33 | -$2.80 | -$1.97 | -$2.11 | -$1.95 | -$2.59 | $0.41 | -$0.97 | -$0.41 | -$1.24 | -$2.30 | -$25.82 | -$27.61 | $15.42 | — | — | — | — | — | — | — | — | — | — | — |
| Diluted EPSper diluted share | -$6.54 | -$5.26 | -$5.45 | -$4.33 | -$2.80 | -$1.97 | -$2.11 | -$1.95 | -$2.59 | $0.39 | -$0.97 | -$0.41 | -$1.24 | -$2.30 | -$25.82 | -$27.61 | $15.06 | — | — | — | — | — | — | — | — | — | — | — |
Reported shareholders
Reported holdings Number of shares
| Holder | Shares held |
|---|---|
BlackRock, Inc. | 20.09M |
T. Rowe Price Investment Management, Inc. | 18.72M |
WELLINGTON MANAGEMENT GROUP LLP | 6.93M |
VANGUARD PORTFOLIO MANAGEMENT LLC | 6.71M |
STATE STREET CORP | 6.49M |
VANGUARD CAPITAL MANAGEMENT LLC | 6.12M |
FMR LLC | 5.03M |
Avoro Capital Advisors LLC | 5M |
BANK OF AMERICA CORP /DE/ | 4.64M |
GEODE CAPITAL MANAGEMENT, LLC | 3.71M |
RTW INVESTMENTS, LP | 2.86M |
Polar Capital Holdings Plc | 2.25M |
PRICE T ROWE ASSOCIATES INC /MD/ | 1.96M |
GOLDMAN SACHS GROUP INC | 1.76M |
Capital Research Global Investors | 1.69M |
NORTHERN TRUST CORP | 1.65M |
WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 1.6M |
Integral Health Asset Management, LLC | 1.6M |
JPMORGAN CHASE & CO | 1.59M |
Point72 Asset Management, L.P. | 1.59M |
Bars compare reported share counts. A matching total for this share class and reporting period is unavailable, so percentages are not shown.
| Transaction | Insider | Type | Shares | Price | Value | Owned after |
|---|---|---|---|---|---|---|
| Jun 29, 2026Form 4 · 10b5-1 | Lee SungEVP, Chief Financial Officer | SellCommon Stock | 3.1K | $85.00 | $266.4K | 63.2K |
| Jun 24, 2026Form 4 · 10b5-1 | Lee SungEVP, Chief Financial Officer | SellCommon Stock | 38.7K | $82.30 | $3.19M | 63.2K |
| Jun 23, 2026Form 4 · 10b5-1 | Malik Fady IbrahamEVP Research & Development | SellCommon Stock | 3.5K | $79.51 | $278.3K | 153.9K |
| Jun 15, 2026Form 4 · 10b5-1 | Blum Robert IPresident & CEO | SellCommon Stock | 7.5K | $70.46 | $528.5K | 385.3K |
| Jun 9, 2026Form 4 · 10b5-1 | Malik Fady IbrahamEVP Research & Development | SellCommon Stock | 3.5K | $67.98 | $237.9K | 153.9K |