Revenue
2010
2011
2012
2013
2014
2015
2016
2017
2018
2018
2019
2020
2021
2022
2023
2024
2025
| 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 · Dec 31 | 2018 · Jun 30 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | $31.4M | $43.3M | $46.0M | $41.4M | $36.9M | $34.4M | $20.4M | $4.6M | $3.0M | $7.5M | $1.6M | $26.6M | $3.5M | $2.1M | $3.5M | $5.0M | $23.1M |
| Research & development | $221.0M | $132.9M | $64.7M | $49.6M | $28.5M | $17.4M | $15.4M | $18.5M | $16.2M | $14.9M | $14.4M | $12.1M | $9.6M | $7.0M | $7.0M | $6.9M | $7.0M |
| Operating expenses | $274.8M | $189.1M | $121.1M | $141.0M | $92.2M | $71.7M | $68.2M | $43.6M | $29.2M | $26.1M | $23.4M | $20.1M | $17.0M | $14.2M | $28.7M | $15.0M | $14.0M |
| Operating income | −$243.4M | −$145.9M | −$75.1M | −$99.6M | −$55.3M | −$37.3M | −$47.9M | −$39.0M | −$26.3M | −$18.6M | −$21.8M | $6.4M | −$13.5M | −$12.0M | −$25.2M | −$10.0M | $9.1M |
| Operating margin | −775.98% | −337.06% | −163.13% | −240.65% | −149.64% | −108.28% | −235.02% | −853.62% | −887.34% | −246.40% | −1,344.07% | 24.17% | −388.42% | −561.41% | −715.00% | −201.47% | 39.44% |
| EBITDA | −$241.1M | −$144.3M | −$74.6M | −$97.2M | −$52.5M | −$34.6M | −$45.3M | −$38.9M | −$25.1M | −$17.8M | −$20.9M | $7.3M | −$12.6M | −$11.0M | −$23.0M | −$6.6M | $12.4M |
| EBITDA margin | −768.62% | −333.50% | −162.12% | −234.74% | −142.14% | −100.59% | −222.23% | −851.50% | −848.56% | −235.59% | −1,288.02% | 27.49% | −362.02% | −515.03% | −651.84% | −133.90% | 53.86% |
| Net income | −$232.0M | −$130.9M | −$70.8M | −$102.3M | −$58.4M | −$45.4M | −$56.8M | −$86.1M | −$53.2M | −$18.5M | −$21.5M | $6.3M | −$13.4M | −$11.9M | −$24.8M | −$8.6M | $8.8M |
| Net profit margin | −739.42% | −302.43% | −153.84% | −246.97% | −158.14% | −131.82% | −278.88% | −1,884.16% | −1,795.71% | −245.19% | −1,330.06% | 23.89% | −384.54% | −555.30% | −704.34% | −173.78% | 37.97% |
| Basic EPSper basic share | -$3.17 | -$2.32 | -$1.82 | -$2.74 | -$2.03 | -$3.54 | -$5.44 | -$12.70 | -$11.50 | -$5.20 | -$6.80 | $2.20 | -$4.90 | -$5.20 | -$11.90 | -$4.40 | $4.80 |
| Diluted EPSper diluted share | -$3.17 | -$2.32 | -$1.82 | -$2.74 | -$2.03 | -$3.54 | -$5.44 | -$12.70 | -$11.50 | -$5.20 | -$6.80 | $2.10 | -$4.90 | -$5.20 | -$11.90 | -$4.40 | $4.60 |
Reported shareholders
| Holder | % owned |
|---|---|
MONTANOVA CAPITAL, LLC | 9.76%8.3M shares |
BlackRock, Inc. | 8.78%7.46M shares |
Cormorant Asset Management, LP | 8.24%7M shares |
FEDERATED HERMES, INC. | 6.69%5.68M shares |
ADAGE CAPITAL PARTNERS GP, L.L.C. | 5.68%4.83M shares |
FRANKLIN RESOURCES INC | 5.66%4.81M shares |
Commodore Capital LP | 5.41%4.6M shares |
Jupiter Topco LLC | 4.44%3.77M shares |
VANGUARD CAPITAL MANAGEMENT LLC | 4.27%3.63M shares |
Paradigm Biocapital Advisors LP | 3.40%2.89M shares |
STATE STREET CORP | 2.77%2.36M shares |
GEODE CAPITAL MANAGEMENT, LLC | 2.43%2.06M shares |
Aberdeen Group plc | 2.36%2.01M shares |
CITADEL ADVISORS LLC | 2.33%1.98M shares |
Balyasny Asset Management L.P. | 2.13%1.81M shares |
Parkman Healthcare Partners LLC | 1.52%1.29M shares |
EVENTIDE ASSET MANAGEMENT, LLC | 1.47%1.25M shares |
TWO SIGMA INVESTMENTS, LP | 1.39%1.18M shares |
Essex Woodlands Management, Inc. | 1.28%1.08M shares |
ORBIMED ADVISORS LLC | 1.26%1.07M shares |
Percentages use 84.98M shares of this listed class outstanding on Jun 30, 2026.
Gray completes the 100% scale. Reported positions may overlap; holders have different reporting dates.
| Transaction | Insider | Type | Shares | Price | Value | Owned after |
|---|---|---|---|---|---|---|
| Apr 17, 2026Form 4 · 10b5-1 | Ribeiro RamiroChief Medical Officer | SellCommon Stock | 2.4K | $15.00 | $36.6K | 0 |
| Mar 16, 2026Form 4 | Duker Jay S.President and CEO | BuyCommon Stock · indirect | 1.5K | $13.15 | $19.7K | 100.7K |
| Mar 4, 2026Form 4 · 10b5-1 | Ribeiro RamiroChief Medical Officer | SellCommon Stock | 2.4K | $17.87 | $43.6K | 0 |
| Feb 17, 2026Form 4 · 10b5-1 | Ribeiro RamiroChief Medical Officer | SellCommon Stock | 2.4K | $15.00 | $36.6K | 0 |
| Jan 5, 2026Form 4 · 10b5-1 | Ribeiro RamiroChief Medical Officer | SellCommon Stock | 42.5K | $17.10 | $727.5K | 0 |