Revenue
2009
2010
2011
2012
2013
2014
2015
2016
2017
2018
2019
2020
2021
2022
2023
2024
2025
| 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | $183.9M | $77.0M | $237,000 | $596,000 | $1.4M | $253,000 | $460,000 | $1.1M | $1.1M | $6.2M | $36.4M | $1.2M | $1.3M | $2.7M | $2.4M | $3.6M | $1.7M |
| Research & development | $71.4M | $103.7M | $125.0M | $95.5M | $85.7M | $51.5M | $52.1M | $13.4M | $11.0M | $18.0M | $17.8M | $20.7M | $23.2M | $51.4M | $69.3M | $61.7M | $57.6M |
| Operating expenses | $252.5M | $250.7M | $194.2M | $139.1M | $115.4M | $77.2M | $73.0M | $32.1M | $30.3M | $36.8M | $36.9M | $37.5M | $40.2M | $74.5M | $98.6M | $114.7M | $72.0M |
| Operating income | −$68.6M | −$173.7M | −$193.9M | −$138.6M | −$114.0M | −$76.9M | −$72.5M | −$31.1M | −$29.3M | −$30.6M | −$559,000 | −$36.3M | −$39.0M | −$71.8M | −$96.1M | −$111.2M | −$70.2M |
| Operating margin | −37.30% | −225.64% | −81,832.91% | −23,246.64% | −8,183.70% | −30,400.40% | −15,761.96% | −2,914.92% | −2,746.95% | −497.34% | −1.54% | −3,149.35% | −3,036.48% | −2,648.87% | −3,942.41% | −3,120.04% | −4,069.18% |
| EBITDA | −$68.1M | −$173.2M | −$193.5M | −$138.3M | −$113.8M | −$76.8M | −$72.4M | −$31.0M | −$29.2M | −$30.6M | −$503,000 | — | — | — | — | — | — |
| EBITDA margin | −37.04% | −224.93% | −81,646.41% | −23,198.32% | −8,168.27% | −30,337.94% | −15,748.04% | −2,909.38% | −2,739.81% | −496.02% | −1.38% | — | — | — | — | — | — |
| Net income | −$83.5M | −$174.6M | −$184.1M | −$141.9M | −$116.1M | −$75.6M | −$68.5M | −$27.0M | −$27.9M | −$29.5M | $46,000 | −$35.7M | −$38.4M | −$68.9M | −$96.9M | −$111.4M | −$70.2M |
| Net profit margin | −45.41% | −226.73% | −77,690.72% | −23,808.89% | −8,335.39% | −29,888.14% | −14,901.74% | −2,534.43% | −2,621.22% | −479.34% | 0.13% | −3,093.67% | −2,991.35% | −2,542.67% | −3,972.64% | −3,125.93% | −4,066.28% |
| Basic EPSper basic share | -$0.13 | -$0.27 | -$0.32 | -$0.37 | -$0.35 | -$0.28 | -$0.36 | -$0.15 | -$0.18 | -$0.19 | $0.00 | -$0.23 | -$0.30 | -$0.54 | -$0.78 | -$1.14 | -$0.80 |
| Diluted EPSper diluted share | -$0.13 | -$0.27 | -$0.32 | -$0.37 | -$0.35 | -$0.28 | -$0.36 | -$0.15 | -$0.18 | -$0.19 | $0.00 | -$0.23 | -$0.30 | -$0.54 | -$0.78 | -$1.14 | -$0.80 |
Reported shareholders
Reported holdings Number of shares
| Holder | Shares held |
|---|---|
BlackRock, Inc. | 49.12M |
RA CAPITAL MANAGEMENT, L.P. | 42.81M |
Soleus Capital Management, L.P. | 42.81M |
STATE STREET CORP | 35.86M |
CITADEL ADVISORS LLC | 29.04M |
VANGUARD CAPITAL MANAGEMENT LLC | 27.25M |
Nantahala Capital Management, LLC | 24.45M |
Clearbridge Investments, LLC | 19.65M |
Eversept Partners, LP | 18.72M |
GOLDMAN SACHS GROUP INC | 16.63M |
GEODE CAPITAL MANAGEMENT, LLC | 14.56M |
MORGAN STANLEY | 12.95M |
VANGUARD PORTFOLIO MANAGEMENT LLC | 10.81M |
Vivo Capital, LLC | 8.67M |
MILLENNIUM MANAGEMENT LLC | 8.11M |
Kynam Capital Management, LP | 6.84M |
Candriam S.C.A. | 5.59M |
FMR LLC | 5.5M |
Pale Fire Capital SE | 5.31M |
NORTHERN TRUST CORP | 5.03M |
Bars compare reported share counts. A matching total for this share class and reporting period is unavailable, so percentages are not shown.
| Transaction | Insider | Type | Shares | Price | Value | Owned after |
|---|---|---|---|---|---|---|
| Feb 18, 2026Form 4 | ROBERTSON MICHELLEEVP, CHIEF FINANCIAL OFFICER | SellCommon Stock | 9.9K | $1.94 | $19.1K | 17.6K |
| May 9, 2025Form 4 | LAWLIS V BRYANDirector | BuyCommon Stock | 13.3K | $1.18 | $15.7K | 13.3K |
| Feb 27, 2025Form 4 | Samuels Scott AlanEVP, Chief Legal Officer | BuyCommon Stock | 15.0K | $1.61 | $24.1K | 26.7K |
| Feb 27, 2025Form 4 | SCARLETT JOHN AChairman, President and CEO | BuyCommon Stock | 12.5K | $1.77 | $22.1K | 12.5K |
| Feb 27, 2025Form 4 | Ziegler JamesEVP, Chief Commercial Officer | BuyCommon Stock | 100.0K | $1.60 | $160.0K | 100.0K |