Karyopharm Therapeutics annual operating margin
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Karyopharm Therapeutics Operating Margin Growth & History (KPTI)
Karyopharm Therapeutics's operating margin was −62.10% for fiscal 2025.
View full Karyopharm Therapeutics company overviewKaryopharm Therapeutics annual operating margin history
| Fiscal year | Period ended | Operating margin | Change (percentage points) |
|---|---|---|---|
| 2025 | 2025-12-31 | −62.10% | +20.14 pp |
| 2024 | 2024-12-31 | −82.24% | +6.47 pp |
| 2023 | 2023-12-31 | −88.71% | +1.83 pp |
| 2022 | 2022-12-31 | −90.53% | −43.70 pp |
| 2021 | 2021-12-31 | −46.84% | +112.16 pp |
| 2020 | 2020-12-31 | −159.00% | +303.86 pp |
| 2019 | 2019-12-31 | −462.85% | +130.11 pp |
| 2018 | 2018-12-31 | −592.97% | +7540.24 pp |
| 2017 | 2017-12-31 | −8,133.21% | +63770.69 pp |
| 2016 | 2016-12-31 | −71,903.90% | −24273.50 pp |
| 2015 | 2015-12-31 | −47,630.40% | −14509.88 pp |
| 2014 | 2014-12-31 | −33,120.52% | −24347.91 pp |
| 2013 | 2013-12-31 | −8,772.61% | −6266.30 pp |
| 2012 | 2012-12-31 | −2,506.31% | +4277.24 pp |
| 2011 | 2011-12-31 | −6,783.55% | — |
Karyopharm Therapeutics quarterly operating margin
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| Fiscal quarter | Period ended | Operating margin | Change (percentage points) |
|---|---|---|---|
| Q2 2026 | 2026-06-30 | −67.38% | −3.08 pp |
| Q1 2026 | 2026-03-31 | −76.31% | +34.48 pp |
| Q4 2025 | 2025-12-31 | −52.36% | +50.06 pp |
| Q3 2025 | 2025-09-30 | −34.56% | +33.21 pp |
| Q2 2025 | 2025-06-30 | −64.30% | +1.43 pp |
| Q1 2025 | 2025-03-31 | −110.80% | −8.89 pp |
| Q4 2024 | 2024-12-31 | −102.42% | +9.61 pp |
| Q3 2024 | 2024-09-30 | −67.77% | +19.04 pp |
| Q2 2024 | 2024-06-30 | −65.72% | +12.97 pp |
| Q1 2024 | 2024-03-31 | −101.91% | −22.06 pp |
| Q4 2023 | 2023-12-31 | −112.03% | −11.17 pp |
| Q3 2023 | 2023-09-30 | −86.81% | −1.49 pp |
| Q2 2023 | 2023-06-30 | −78.70% | +29.44 pp |
| Q1 2023 | 2023-03-31 | −79.85% | −7.29 pp |
| Q4 2022 | 2022-12-31 | −100.86% | −138.05 pp |
| Q3 2022 | 2022-09-30 | −85.32% | +30.93 pp |
| Q2 2022 | 2022-06-30 | −108.14% | +108.88 pp |
| Q1 2022 | 2022-03-31 | −72.55% | +152.61 pp |
| Q4 2021 | 2021-12-31 | 37.19% | +142.79 pp |
| Q3 2021 | 2021-09-30 | −116.25% | +104.58 pp |
| Q2 2021 | 2021-06-30 | −217.02% | −96.71 pp |
| Q1 2021 | 2021-03-31 | −225.16% | +35.92 pp |
| Q4 2020 | 2020-12-31 | −105.60% | +133.49 pp |
| Q3 2020 | 2020-09-30 | −220.83% | +78.82 pp |
| Q2 2020 | 2020-06-30 | −120.30% | +318.82 pp |
| Q1 2020 | 2020-03-31 | −261.09% | +41624.07 pp |
| Q4 2019 | 2019-12-31 | −239.09% | +27651.69 pp |
| Q3 2019 | 2019-09-30 | −299.65% | +20266.88 pp |
| Q2 2019 | 2019-06-30 | −439.12% | −266.52 pp |
| Q1 2019 | 2019-03-31 | −41,885.16% | −41495.74 pp |
| Q4 2018 | 2018-12-31 | −27,890.78% | +963842.56 pp |
| Q3 2018 | 2018-09-30 | −20,566.53% | +23961.41 pp |
| Q2 2018 | 2018-06-30 | −172.60% | +53456.57 pp |
| Q1 2018 | 2018-03-31 | −389.42% | +51264.82 pp |
| Q2 2017 | 2017-06-30 | −991,733.33% | −950920.00 pp |
| Q1 2017 | 2017-03-31 | −44,527.94% | −22519.27 pp |
| Q3 2016 | 2016-09-30 | −53,629.17% | +108508.33 pp |
| Q2 2016 | 2016-06-30 | −51,654.24% | +42364.81 pp |
| Q3 2015 | 2015-09-30 | −40,813.33% | +37510.48 pp |
| Q2 2015 | 2015-06-30 | −22,008.67% | −13989.95 pp |
| Q4 2014 | 2014-12-31 | −162,137.50% | −155129.23 pp |
| Q3 2014 | 2014-09-30 | −94,019.05% | −88853.63 pp |
| Q2 2014 | 2014-06-30 | −78,323.81% | −75915.66 pp |
| Q1 2014 | 2014-03-31 | −8,018.71% | +2672.46 pp |
| Q3 2013 | 2013-09-30 | −7,008.27% | — |
| Q2 2013 | 2013-06-30 | −5,165.41% | — |
| Q1 2013 | 2013-03-31 | −2,408.15% | — |
| Q3 2012 | 2012-09-30 | −10,691.18% | — |
Karyopharm Therapeutics operating margin trends
Over the last five reported fiscal years, Karyopharm Therapeutics's operating margin increased from −159.00% to −62.10%, a change of +96.90 percentage points. The latest reported quarter, Q2 2026, shows −67.38%.
About the metric
What operating margin means
Operating margin measures the percentage of revenue left after operating costs and expenses. It shows how much operating profit a company generates from each dollar of revenue.
Calculation and source
How operating margin is calculated
TickerStat calculates operating margin as SEC-reported operating income divided by SEC-reported revenue for the same fiscal period. Changes are shown in percentage points. Fiscal periods can differ from calendar years, so exact period-end dates are included.
Review Karyopharm Therapeutics filings at SEC.gov ↗