Revenue
2009
2010
2011
2012
2017
2018
2019
2020
2021
2022
2023
2024
2025
| 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | $958.4M | $180.1M | $0 | $0 | $0 | $0 | $0 | $0 | $0 | — | — | — | — | $147,000 | $7.6M | $14.8M | $144.2M |
| Gross profit | $902.3M | $173.9M | $0 | $0 | — | — | — | — | — | — | — | — | — | — | — | — | — |
| Gross margin | 94.14% | 96.54% | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — |
| Research & development | $388.5M | $236.7M | $272.4M | $245.4M | $205.2M | $184.8M | $72.3M | $25.4M | $24.4M | $15.9M | $2.4M | $68.2M | $71.9M | $49.4M | $41.5M | $40.3M | $51.1M |
| Operating expenses | $1.26B | $678.0M | $380.5M | $293.6M | $242.5M | $206.7M | $95.0M | $40.7M | $32.1M | $25.2M | $3.2M | $84.0M | $87.6M | $61.1M | $53.0M | $51.7M | $64.9M |
| Operating income | −$300.1M | −$497.9M | −$380.5M | −$293.6M | −$242.5M | −$206.7M | −$95.0M | −$40.7M | −$32.1M | −$25.2M | −$3.2M | −$84.0M | −$87.6M | −$60.9M | −$45.4M | −$36.9M | $79.3M |
| Operating margin | −31.31% | −276.39% | — | — | — | — | — | — | — | — | — | — | — | −41,456.46% | −599.05% | −249.26% | 54.98% |
| EBITDA | −$298.6M | −$496.8M | −$380.0M | −$293.1M | −$242.1M | −$206.2M | −$94.9M | −$40.6M | −$32.0M | −$25.2M | −$2.6M | −$83.3M | −$87.0M | −$60.2M | −$44.0M | −$35.0M | $81.8M |
| EBITDA margin | −31.16% | −275.78% | — | — | — | — | — | — | — | — | — | — | — | −40,954.42% | −579.75% | −236.20% | 56.69% |
| Net income | −$288.3M | −$465.9M | −$373.6M | −$295.4M | −$241.8M | −$202.2M | −$83.9M | −$32.8M | −$31.2M | −$26.4M | — | — | — | — | — | — | — |
| Net profit margin | −30.08% | −258.64% | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — |
| Basic EPSper basic share | -$12.85 | -$21.90 | -$19.99 | -$17.23 | -$14.63 | -$13.09 | -$5.45 | -$2.22 | -$2.54 | -$5.07 | -$40.03 | -$0.87 | -$1.27 | -$1.06 | -$1.00 | -$0.93 | $2.33 |
| Diluted EPSper diluted share | -$12.85 | -$21.90 | -$19.99 | -$17.23 | -$14.63 | -$13.09 | -$5.45 | -$2.22 | -$2.54 | -$5.07 | -$40.03 | -$0.87 | -$1.27 | -$1.06 | -$1.00 | -$0.93 | $2.32 |
Reported shareholders
| Holder | % owned |
|---|---|
BAKER BROS. ADVISORS LP | 9.28%2.14M shares |
RTW INVESTMENTS, LP | 8.63%1.99M shares |
Jupiter Topco LLC | 8.38%1.94M shares |
Avoro Capital Advisors LLC | 7.94%1.83M shares |
PAULSON & CO. INC. | 5.80%1.34M shares |
BlackRock, Inc. | 5.20%1.2M shares |
Taub Rebecca | ≈4.80%1.11M shares |
VANGUARD CAPITAL MANAGEMENT LLC | 3.62%835.67K shares |
WELLINGTON MANAGEMENT GROUP LLP | 3.58%825.71K shares |
VANGUARD PORTFOLIO MANAGEMENT LLC | 3.38%781.73K shares |
STATE STREET CORP | 2.28%527.06K shares |
CITADEL ADVISORS LLC | 2.20%507.23K shares |
UBS Group AG | 1.74%401.71K shares |
GEODE CAPITAL MANAGEMENT, LLC | 1.62%374.88K shares |
FMR LLC | 1.54%356.2K shares |
WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 1.40%324.12K shares |
Invesco Ltd. | 1.31%301.44K shares |
ARMISTICE CAPITAL, LLC | 1.25%288K shares |
LORD, ABBETT & CO. LLC | 1.22%281.5K shares |
Assenagon Asset Management S.A. | 1.08%248.43K shares |
Percentages use 23.09M shares of this listed class outstanding on Jun 30, 2026. ≈ compares the latest reported holding with a share total from a different date; it is not a confirmed current stake.
Gray completes the 100% scale. Reported positions may overlap; holders have different reporting dates.
| Transaction | Insider | Type | Shares | Price | Value | Owned after |
|---|---|---|---|---|---|---|
| Jun 1, 2026Form 4 · 10b5-1 | Soergel DavidChief Medical Officer | SellCommon Stock | 1.0K | $495.74 | $516.6K | 10.0K |
| May 22, 2026Form 4 · 10b5-1 | Levy Richard SDirector | SellCommon Stock | 80 | $519.98 | $41.6K | 22.0K |
| May 22, 2026Form 4 · 10b5-1 | Levy Richard SDirector | SellCommon Stock | 782 | $518.76 | $405.7K | 22.1K |
| May 22, 2026Form 4 · 10b5-1 | Levy Richard SDirector | SellCommon Stock | 1.5K | $517.59 | $774.8K | 22.9K |
| May 22, 2026Form 4 · 10b5-1 | Levy Richard SDirector | SellCommon Stock | 723 | $516.87 | $373.7K | 24.4K |