Revenue
2018
2022
2023
2024
2025
| 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | $0 | $925,000 | $0 | $0 | — | — | — | $25.0M | — | — | — | — | — | — |
| Research & development | $75.0M | $60.9M | $44.4M | $47.5M | $39.2M | $24.3M | $4.4M | $41.8M | $36.3M | $28.4M | $15.8M | $18.1M | $7.6M | $6.0M |
| Operating expenses | $103.3M | $83.5M | $55.6M | $56.5M | $60.7M | — | $71.0M | $57.6M | $51.1M | $37.6M | $21.3M | $22.4M | $9.4M | $7.7M |
| Operating income | −$103.3M | −$82.6M | −$55.6M | −$56.5M | −$60.7M | −$33.7M | −$71.0M | −$32.6M | −$51.1M | −$37.6M | — | — | — | — |
| Operating margin | — | −8,930.27% | — | — | — | — | — | −130.50% | — | — | — | — | — | — |
| EBITDA | −$100.3M | −$79.4M | −$52.3M | −$53.3M | −$59.4M | −$32.9M | −$70.6M | −$32.3M | −$50.8M | — | — | — | — | — |
| EBITDA margin | — | −8,584.86% | — | — | — | — | — | −129.34% | — | — | — | — | — | — |
| Net income | −$90.4M | −$75.1M | −$36.3M | −$55.2M | −$60.7M | −$33.3M | −$69.4M | −$31.6M | −$50.2M | −$37.0M | −$21.9M | −$24.0M | −$8.7M | −$7.7M |
| Net profit margin | — | −8,123.68% | — | — | — | — | — | −126.34% | — | — | — | — | — | — |
| Basic EPSper basic share | -$4.24 | -$4.28 | -$73.84 | -$20.80 | -$22.00 | -$12.80 | -$51.40 | -$26.80 | -$42.80 | -$39.20 | -$34.60 | -$55.00 | -$990.40 | -$804.60 |
| Diluted EPSper diluted share | -$4.24 | -$4.28 | -$73.84 | -$20.80 | -$22.00 | -$12.80 | -$51.40 | -$26.80 | -$42.80 | -$39.20 | -$34.60 | -$55.00 | -$990.40 | -$804.60 |
Reported shareholders
| Holder | % owned |
|---|---|
AKKARAJU SRINIVAS / Samsara BioCapital, L.P. / Samsara BioCapital GP, LLC | ≈10.85%1.72M shares |
SAMSARA BIOCAPITAL, LLC | 10.85%1.72M shares |
Casdin Capital, LLC | 9.76%1.55M shares |
Redmile Group, LLC | 8.92%1.41M shares |
RTW INVESTMENTS, LP | 8.61%1.36M shares |
McMinn Rachel | ≈8.49%1.34M shares |
EcoR1 Capital, LLC | 8.03%1.27M shares |
BlackRock, Inc. | 6.68%1.06M shares |
BAKER BROS. ADVISORS LP | 6.26%991.69K shares |
Balyasny Asset Management L.P. | 5.17%818.71K shares |
Trails Edge Capital Partners, LP | 4.52%714.89K shares |
TORONTO DOMINION BANK | 4.30%681.34K shares |
VANGUARD CAPITAL MANAGEMENT LLC | 3.39%536.53K shares |
JENNISON ASSOCIATES LLC | 3.28%518.58K shares |
CITADEL ADVISORS LLC | 2.58%408.98K shares |
GREAT POINT PARTNERS LLC | 2.22%352.18K shares |
ArrowMark Colorado Holdings LLC | 2.16%342.45K shares |
FMR LLC | 1.87%295.56K shares |
GEODE CAPITAL MANAGEMENT, LLC | 1.85%293.18K shares |
STATE STREET CORP | 1.42%224.32K shares |
Percentages use 15.83M shares of this listed class outstanding on Jun 30, 2026. ≈ compares the latest reported holding with a share total from a different date; it is not a confirmed current stake.
Reported positions exceed 100% in total, so the circle shows the selected holder only.
| Transaction | Insider | Type | Shares | Price | Value | Owned after |
|---|---|---|---|---|---|---|
| May 6, 2026Form 4 · 10b5-1 | Cvijic Christine MikailPresident and CFO | SellCommon Stock | 4.8K | $32.44 | $155.7K | 93.6K |
| May 6, 2026Form 4 · 10b5-1 | Cvijic Christine MikailPresident and CFO | SellCommon Stock | 4.8K | $30.07 | $144.3K | 98.4K |
| Mar 26, 2026Form 4 · 10b5-1 | Jordan JulieChief Medical Officer | SellCommon Stock | 828 | $21.89 | $18.1K | 12.5K |
| Mar 26, 2026Form 4 · 10b5-1 | McMinn RachelChief Executive Officer | SellCommon Stock | 3.4K | $22.07 | $74.0K | 1.34M |
| Mar 26, 2026Form 4 · 10b5-1 | Cvijic Christine MikailPresident and CFO | SellCommon Stock | 2.6K | $21.62 | $55.3K | 103.2K |