Revenue
2014
2015
2016
2017
2018
2019
2020
2021
2022
2023
2025
| 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | $0 | — | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | — | — | — | — | — | — | — | — | — | — |
| Research & development | $100.6M | $75.1M | $1.0M | $4.7M | $13.8M | $5.0M | $1.8M | $4.2M | $14.1M | $12.3M | $7.1M | $5.6M | $2.9M | $1.1M | $2.3M | $3.1M | — | — | — | — | — | — |
| Operating expenses | $122.1M | $88.1M | $7.3M | $10.6M | $19.3M | $9.8M | $5.8M | $8.1M | $18.7M | $16.6M | $11.5M | $9.7M | $6.9M | $4.3M | $7.4M | $9.2M | — | — | — | — | — | — |
| Operating income | −$122.1M | −$88.1M | −$7.3M | −$10.6M | −$19.3M | −$9.8M | −$5.8M | −$8.1M | −$18.7M | −$16.6M | −$11.5M | −$9.7M | −$6.9M | −$4.3M | −$7.4M | −$9.2M | — | — | — | — | — | — |
| EBITDA | −$122.0M | −$88.1M | −$7.3M | −$10.6M | −$19.3M | −$9.8M | −$5.8M | −$8.1M | −$18.7M | −$16.6M | −$11.4M | −$9.7M | −$6.9M | −$4.3M | −$6.8M | −$8.8M | — | — | — | — | — | — |
| Net income | −$105.4M | −$83.7M | −$5.3M | −$9.9M | −$19.3M | −$9.7M | −$5.5M | −$7.9M | −$18.5M | −$16.4M | −$11.4M | −$9.7M | −$6.9M | −$4.3M | −$5.4M | −$8.4M | −$9.1M | −$19.4M | −$14.0M | −$5.2M | −$1.5M | −$511,000 |
| Basic EPSper basic share | -$1.85 | -$3.87 | -$0.37 | -$0.69 | -$1.39 | -$2.07 | -$4.15 | -$10.31 | -$31.86 | -$32.58 | -$32.76 | -$59.58 | -$131.04 | -$244.44 | -$404.46 | -$748.44 | — | — | — | — | — | — |
| Diluted EPSper diluted share | -$1.85 | -$3.87 | -$0.37 | -$0.69 | -$1.39 | -$2.07 | -$4.15 | -$10.31 | -$31.86 | -$32.58 | -$32.76 | -$59.58 | -$131.04 | -$244.44 | -$404.46 | -$748.44 | — | — | — | — | — | — |
Reported shareholders
| Holder | % owned |
|---|---|
FMR LLC | 14.83%9.06M shares |
BlackRock, Inc. | 8.17%4.99M shares |
VHCP Management III, LLC / Venrock Healthcare Capital Partners III, L.P. / VHCP Management EG, LLC / VHCP Co-Investment Holdings III, LLC / Koh Bong Y / Shah Nimish P / Venrock Healthcare Capital Partners EG, L.P. | ≈6.79%4.15M shares |
Venrock Adviser, LLC | 6.79%4.15M shares |
Fairmount Funds Management LLC | 6.07%3.71M shares |
Capital World Investors | 5.57%3.4M shares |
RTW INVESTMENTS, LP | 5.14%3.14M shares |
STATE STREET CORP | 4.38%2.67M shares |
VANGUARD CAPITAL MANAGEMENT LLC | 3.87%2.36M shares |
Paradigm Biocapital Advisors LP | 3.51%2.14M shares |
Janus Henderson Biotech Innovation Master Fund Ltd / JANUS HENDERSON GROUP PLC | ≈3.47%2.12M shares |
Deep Track Capital, LP | 3.15%1.93M shares |
Bellevue Group AG | 2.71%1.66M shares |
FRANKLIN RESOURCES INC | 2.66%1.62M shares |
Remedium Capital Partners, LLC | 2.56%1.57M shares |
RA CAPITAL MANAGEMENT, L.P. | 2.55%1.55M shares |
VIKING GLOBAL INVESTORS LP | 2.46%1.5M shares |
GEODE CAPITAL MANAGEMENT, LLC | 2.34%1.43M shares |
Jupiter Topco LLC | 2.25%1.38M shares |
PERCEPTIVE ADVISORS LLC | 2.20%1.35M shares |
Percentages use 61.07M shares of this listed class outstanding on Jun 30, 2026. ≈ compares the latest reported holding with a share total from a different date; it is not a confirmed current stake.
Gray completes the 100% scale. Reported positions may overlap; holders have different reporting dates.
| Transaction | Insider | Type | Shares | Price | Value | Owned after |
|---|---|---|---|---|---|---|
| Jun 22, 2026Form 4 · 10b5-1 | Agarwal ArjunSenior Vice President, Finance | SellCommon Stock | 699 | $82.15 | $57.4K | 15.3K |
| Jun 22, 2026Form 4 · 10b5-1 | Agarwal ArjunSenior Vice President, Finance | SellCommon Stock | 888 | $80.01 | $71.0K | 16.0K |
| Jun 15, 2026Form 4 · 10b5-1 | Agarwal ArjunSenior Vice President, Finance | SellCommon Stock | 395 | $69.69 | $27.5K | 16.9K |
| Jun 15, 2026Form 4 · 10b5-1 | Goncalves JoanaChief Medical Officer | SellCommon Stock | 947 | $69.69 | $66.0K | 32.7K |
| Jun 15, 2026Form 4 · 10b5-1 | Goncalves JoanaChief Medical Officer | SellCommon Stock | 300 | $70.62 | $21.2K | 33.7K |