Revenue
2020
2021
2022
2023
2024
2025
| 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | $7.3M | $566,000 | $392,000 | $1.5M | $208.4M | $12.6M | — | — | — | — | — |
| Research & development | $25.6M | $36.8M | $28.6M | $24.6M | $46.9M | $63.4M | $42.2M | $33.8M | $50.0M | $9.6M | $6.6M |
| Operating expenses | $49.7M | $62.5M | $59.7M | $57.1M | $84.2M | $94.0M | $61.4M | $52.9M | $65.0M | $22.5M | $13.2M |
| Operating income | −$42.4M | −$61.9M | −$59.3M | −$55.5M | $124.2M | −$81.4M | −$61.4M | −$52.9M | −$65.0M | −$22.5M | −$13.2M |
| Operating margin | −585.20% | −10,933.75% | −15,122.70% | −3,696.44% | 59.61% | −645.40% | — | — | — | — | — |
| EBITDA | −$42.2M | −$61.3M | −$58.7M | −$55.0M | $124.4M | −$81.1M | −$61.2M | −$52.8M | −$64.9M | −$22.5M | −$13.2M |
| EBITDA margin | −581.44% | −10,825.44% | −14,977.81% | −3,662.33% | 59.72% | −642.96% | — | — | — | — | — |
| Net income | −$17.4M | −$26.4M | −$52.3M | −$54.2M | $122.8M | −$81.0M | −$60.5M | −$52.0M | −$64.8M | −$22.4M | −$13.2M |
| Net profit margin | −240.13% | −4,670.14% | −13,351.79% | −3,604.66% | 58.95% | −642.26% | — | — | — | — | — |
| Basic EPSper basic share | -$0.23 | -$0.37 | -$0.74 | -$0.77 | $1.78 | -$1.39 | — | -$2.11 | -$3.35 | -$2.28 | -$1.36 |
| Diluted EPSper diluted share | -$0.23 | -$0.37 | -$0.74 | -$0.77 | $1.76 | -$1.39 | — | -$2.11 | -$3.35 | -$2.28 | -$1.36 |
Reported shareholders
| Holder | % owned |
|---|---|
Jupiter Topco LLC | 11.23%20.74M shares |
EVENTIDE ASSET MANAGEMENT, LLC | 6.39%11.81M shares |
BlackRock, Inc. | 5.86%10.82M shares |
RA CAPITAL MANAGEMENT, L.P. | 5.68%10.5M shares |
Affinity Asset Advisors, LLC | 5.49%10.14M shares |
Takeda Pharmaceuticals U.S.A., Inc. / TAKEDA PHARMACEUTICAL CO LTD | ≈4.75%8.78M shares |
STATE STREET CORP | 4.28%7.9M shares |
VANGUARD CAPITAL MANAGEMENT LLC | 4.20%7.76M shares |
ADAR1 Capital Management, LLC | 4.01%7.42M shares |
Balyasny Asset Management L.P. | 3.64%6.72M shares |
ADAGE CAPITAL PARTNERS GP, L.L.C. | 3.34%6.16M shares |
FEDERATED HERMES, INC. | 3.22%5.95M shares |
BRAIDWELL LP | 3.20%5.92M shares |
GEODE CAPITAL MANAGEMENT, LLC | 2.20%4.07M shares |
LEVIN JEREMY M | ≈2.04%3.77M shares |
SILVERARC CAPITAL MANAGEMENT, LLC | 1.68%3.1M shares |
STEMPOINT CAPITAL LP | 1.31%2.42M shares |
Ikarian Capital, LLC | 1.23%2.27M shares |
Point72 Asset Management, L.P. | 1.05%1.95M shares |
SPHERA FUNDS MANAGEMENT LTD. | 0.73%1.35M shares |
Percentages use 184.76M shares of this listed class outstanding on Jun 30, 2026. ≈ compares the latest reported holding with a share total from a different date; it is not a confirmed current stake.
Gray completes the 100% scale. Reported positions may overlap; holders have different reporting dates.
| Transaction | Insider | Type | Shares | Price | Value | Owned after |
|---|---|---|---|---|---|---|
| Feb 23, 2026Form 4 | ALEXANDER MARGARET A.President and CEO | SellCommon Stock | 11.7K | $1.45 | $16.9K | 61.8K |
| Feb 23, 2026Form 4 | Rona Jeffrey ACBFO | SellCommon Stock | 8.5K | $1.45 | $12.4K | 88.2K |
| Dec 11, 2025Form 4 | LEVIN JEREMY MCEO | BuySeries B Warrant (right to buy) · derivative | 35.5K | — | — | 35.5K |
| Dec 11, 2025Form 4 | LEVIN JEREMY MCEO | BuySeries A Warrant (right to buy) · derivative | 47.3K | — | — | 47.3K |
| Dec 11, 2025Form 4 | LEVIN JEREMY MCEO | BuySeries B Convertible Preferred Stock · derivative | 71 | — | — | 71 |