Revenue
2014
2022
2023
2024
2025
| 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | $0 | $0 | $0 | $0 | — | — | — | — | — | — | — | $2.9M | — | — |
| Research & development | $42.6M | $31.7M | $25.0M | $16.8M | $21.1M | $12.0M | $3.9M | $11.8M | $21.7M | $18.9M | $12.4M | $6.4M | $4.0M | $5.9M |
| Operating expenses | $64.5M | $49.2M | $43.6M | $67.1M | $47.5M | $34.4M | $7.8M | $21.4M | $30.4M | $28.7M | $20.9M | $10.5M | $7.1M | $8.0M |
| Operating income | −$64.5M | −$49.2M | −$43.6M | −$67.1M | −$47.5M | −$34.4M | −$7.8M | −$21.4M | −$30.4M | −$28.7M | −$20.9M | −$7.6M | −$7.1M | −$8.0M |
| Operating margin | — | — | — | — | — | — | — | — | — | — | — | −257.12% | — | — |
| EBITDA | −$64.2M | −$48.8M | −$43.3M | −$66.8M | −$47.4M | −$34.3M | −$7.8M | −$21.3M | −$30.2M | −$28.6M | −$20.8M | −$7.5M | −$7.1M | −$7.9M |
| EBITDA margin | — | — | — | — | — | — | — | — | — | — | — | −256.11% | — | — |
| Net income | −$57.4M | −$44.6M | −$40.4M | −$66.0M | −$47.3M | −$34.0M | −$7.8M | −$20.7M | −$30.0M | −$28.5M | −$21.4M | −$3.3M | −$7.9M | −$8.0M |
| Net profit margin | — | — | — | — | — | — | — | — | — | — | — | −113.36% | — | — |
| Basic EPSper basic share | -$1.34 | -$2.17 | -$3.57 | -$5.86 | -$4.21 | -$4.70 | -$3.04 | -$45.80 | -$85.20 | -$68.80 | -$52.00 | -$126.40 | -$2,386.40 | -$2,446.40 |
| Diluted EPSper diluted share | -$1.34 | -$2.17 | -$3.57 | -$5.86 | -$4.21 | -$4.70 | -$3.04 | -$45.80 | -$85.20 | -$68.80 | -$52.00 | -$126.40 | -$2,386.40 | -$2,446.40 |
Reported shareholders
| Holder | % owned |
|---|---|
Jupiter Topco LLC | 7.95%4.7M shares |
BlackRock, Inc. | 6.20%3.66M shares |
MILLENNIUM MANAGEMENT LLC | 5.25%3.1M shares |
Velan Capital Investment Management LP | 4.81%2.84M shares |
VANGUARD CAPITAL MANAGEMENT LLC | 3.89%2.3M shares |
Blackstone Inc. | 3.83%2.27M shares |
ORBIMED ADVISORS LLC | 3.76%2.22M shares |
Opaleye Management Inc. | ≈3.37%1.99M shares |
Sio Capital Management, LLC | 3.25%1.92M shares |
ACORN CAPITAL ADVISORS, LLC | 2.97%1.75M shares |
Integral Health Asset Management, LLC | 2.54%1.5M shares |
5AM Venture Management, LLC | 2.32%1.37M shares |
GEODE CAPITAL MANAGEMENT, LLC | 2.24%1.33M shares |
CITADEL ADVISORS LLC | 2.09%1.23M shares |
STATE STREET CORP | 1.81%1.07M shares |
Qube Research & Technologies Ltd | 1.77%1.05M shares |
Balyasny Asset Management L.P. | 1.74%1.03M shares |
Shefferman Jesse | ≈1.73%1.02M shares |
BAKER BROS. ADVISORS LP | 1.64%971.61K shares |
ADAR1 Capital Management, LLC | 1.59%940.51K shares |
Percentages use 59.08M shares of this listed class outstanding on Jun 30, 2026. ≈ compares the latest reported holding with a share total from a different date; it is not a confirmed current stake.
Gray completes the 100% scale. Reported positions may overlap; holders have different reporting dates.
| Transaction | Insider | Type | Shares | Price | Value | Owned after |
|---|---|---|---|---|---|---|
| Apr 8, 2026Form 4 | Zummo JacquelineChief R&D Officer | SellCommon Stock | 1.1K | $5.40 | $6.1K | 94.8K |
| Apr 1, 2026Form 4 | Zummo JacquelineChief R&D Officer | SellCommon Stock | 22.6K | $5.26 | $118.9K | 96.0K |
| May 14, 2025Form 4/A | Levy Richard SDirector | BuyCommon Stock | 20.0K | $3.19 | $63.8K | 51.0K |
| May 14, 2025Form 4 | Levy Richard SDirector | BuyCommon Stock | 20.0K | $3.19 | $63.8K | 51.0K |
| Mar 26, 2025Form 4 · 10b5-1 | Zummo JacquelineChf Scientific Operations Off | SellCommon Stock | 21.2K | $4.53 | $96.1K | 98.9K |