Revenue
2011
2012
2013
2014
2015
2016
2017
2018
2019
2020
2021
2022
2023
2024
2025
| 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | $2.8M | $226,000 | $226,000 | $226,000 | $226,000 | $231,000 | $2.2M | $1.2M | $787,000 | $5.5M | $11.5M | $800,000 | $4.8M | $46.2M | $1.5M |
| Research & development | $12.1M | $12.8M | $11.4M | $11.4M | $7.3M | $16.9M | $15.5M | $16.9M | $19.1M | $20.1M | $25.9M | $49.4M | $50.2M | $52.8M | $22.6M |
| Operating expenses | $20.7M | $142.6M | $20.5M | $19.9M | $16.7M | $25.2M | $23.9M | $24.5M | $26.5M | $29.2M | $35.4M | $64.5M | $67.0M | $68.5M | $29.1M |
| Operating income | −$17.9M | −$142.4M | −$20.3M | −$19.6M | −$16.5M | −$25.0M | −$21.7M | −$23.3M | −$25.7M | −$23.7M | −$24.0M | −$63.7M | −$62.2M | −$22.3M | −$27.6M |
| Operating margin | −640.68% | −62,997.35% | −8,981.42% | −8,684.51% | −7,299.12% | −10,819.48% | −994.00% | −1,895.93% | −3,270.27% | −427.39% | −209.25% | −7,968.00% | −1,309.11% | −48.23% | −1,854.27% |
| EBITDA | −$17.8M | −$142.4M | −$20.3M | −$19.6M | −$16.5M | −$25.0M | −$21.7M | −$23.2M | −$25.6M | −$23.6M | −$23.8M | −$63.3M | −$61.8M | −$22.0M | −$27.3M |
| EBITDA margin | −638.49% | −62,992.04% | −8,974.34% | −8,678.32% | −7,292.92% | −10,813.85% | −993.36% | −1,891.45% | −3,259.09% | −425.66% | −207.94% | −7,913.75% | −1,299.73% | −47.54% | −1,833.02% |
| Net income | $9.2M | −$166.5M | −$18.9M | −$19.0M | −$16.2M | −$25.2M | −$21.5M | −$20.6M | −$24.1M | −$19.7M | −$24.0M | −$63.7M | −$62.5M | −$29.9M | −$26.3M |
| Net profit margin | 328.67% | −73,682.74% | −8,384.07% | −8,391.15% | −7,151.77% | −10,890.48% | −985.02% | −1,675.33% | −3,061.25% | −354.62% | −209.31% | −7,960.25% | −1,315.86% | −64.76% | −1,768.26% |
| Basic EPSper basic share | $0.83 | -$35.21 | -$22.57 | -$22.75 | -$24.00 | -$54.25 | -$8,339.55 | -$27,929.10 | -$224,720.15 | -$5,560,819.50 | -$13,200,684.13 | -$36,821,642.64 | -$76,649,133.66 | -$192,249,052.57 | -$177,595,541.73 |
| Diluted EPSper diluted share | $0.82 | -$35.21 | -$22.57 | -$22.75 | -$24.00 | -$54.25 | -$8,339.55 | -$27,929.10 | -$224,720.15 | -$5,560,819.50 | -$13,200,684.13 | -$36,821,642.64 | -$76,649,133.66 | -$192,249,052.57 | -$177,595,541.73 |
Reported shareholders
| Holder | % owned |
|---|---|
ORBIMED ADVISORS LLC | 7.88%1.2M shares |
Ally Bridge Group (NY) LLC | 5.15%786.24K shares |
ADAGE CAPITAL PARTNERS GP, L.L.C. | 4.78%730K shares |
ADAR1 Capital Management, LLC | 3.92%597.73K shares |
Lynx1 Capital Management LP | 3.67%559.47K shares |
Ikarian Capital, LLC | 3.13%478.14K shares |
SPHERA FUNDS MANAGEMENT LTD. | 2.61%398.49K shares |
VANGUARD CAPITAL MANAGEMENT LLC | 2.16%330.05K shares |
JANE STREET GROUP, LLC | 1.42%216.01K shares |
Dukes Iain D. | ≈1.12%171.13K shares |
Alyeska Investment Group, L.P. | 1.08%164.38K shares |
Savchuk Nikolay | ≈0.99%150.61K shares |
BOOTHBAY FUND MANAGEMENT, LLC | 0.88%133.94K shares |
Pauza Charles David | ≈0.76%115.97K shares |
Redfield Robert | ≈0.75%113.92K shares |
GEODE CAPITAL MANAGEMENT, LLC | 0.73%111.37K shares |
CAUTREELS WERNER | ≈0.72%109.22K shares |
HRT FINANCIAL LP | 0.60%91.22K shares |
Kynam Capital Management, LP | 0.55%84.4K shares |
Dauntless Investment Group, LLC | 0.53%80.57K shares |
Percentages use 15.26M shares of this listed class outstanding on Jun 30, 2026. ≈ compares the latest reported holding with a share total from a different date; it is not a confirmed current stake.
Gray completes the 100% scale. Reported positions may overlap; holders have different reporting dates.
| Transaction | Insider | Type | Shares | Price | Value | Owned after |
|---|---|---|---|---|---|---|
| Apr 16, 2026Form 4 | OrbiMed Capital GP VIII LLC +1TenPercentOwner | BuyCommon Stock · indirect | 597.7K | $1.67 | $998.2K | 1.20M |
| Apr 16, 2026Form 4 | OrbiMed Capital GP VIII LLC +1TenPercentOwner | BuySeries C Warrants (right to buy) · derivative · indirect | 1.79M | — | — | 1.79M |
| Apr 16, 2026Form 4 | OrbiMed Capital GP VIII LLC +1TenPercentOwner | BuySeries B Warrants (right to buy) · derivative · indirect | 597.7K | — | — | 597.7K |
| Apr 16, 2026Form 4 | OrbiMed Capital GP VIII LLC +1TenPercentOwner | BuySeries A Warrants (right to buy) · derivative · indirect | 597.7K | — | — | 597.7K |
| Dec 29, 2024Form 4 | OrbiMed Capital GP VIII LLC +1TenPercentOwner | BuySeries A Warrant (right to buy) · derivative · indirect | 96.3K | — | — | 96.3K |