Revenue
2016
2017
2018
2019
2020
2021
2022
2023
2024
2025
| 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | $109.8M | $90.4M | $82.7M | $64.4M | $48.0M | $11.8M | $18,000 | $1.1M | $8.2M | $17.5M | — |
| Gross profit | $97.3M | $81.5M | $73.4M | $56.7M | $42.9M | $10.8M | $18,000 | −$675,000 | $7.6M | $17.5M | — |
| Gross margin | 88.66% | 90.18% | 88.68% | 88.11% | 89.27% | 91.45% | 100.00% | −59.84% | 92.65% | 99.84% | — |
| Research & development | $67.1M | $57.1M | $45.6M | $52.9M | $47.6M | $47.3M | $49.3M | $36.9M | $18.7M | — | — |
| Operating expenses | $222.2M | $178.3M | $138.9M | $135.7M | $135.2M | $137.5M | $109.5M | $76.5M | $27.5M | $16.7M | — |
| Operating income | −$124.9M | −$96.8M | −$65.5M | −$79.0M | −$92.3M | −$126.7M | −$109.5M | −$77.2M | −$19.9M | $798,000 | −$12.4M |
| Operating margin | −113.73% | −107.06% | −79.23% | −122.82% | −192.11% | −1,074.15% | −608,211.11% | −6,842.20% | −244.55% | 4.55% | — |
| EBITDA | −$124.6M | −$96.5M | −$64.7M | −$78.1M | −$91.5M | −$126.3M | −$109.2M | −$76.8M | −$19.8M | $998,000 | −$12.3M |
| EBITDA margin | −113.45% | −106.70% | −78.26% | −121.38% | −190.38% | −1,070.62% | −606,544.44% | −6,806.74% | −242.09% | 5.69% | — |
| Net income | −$153.5M | −$126.9M | −$102.2M | −$109.8M | −$110.8M | −$128.5M | −$105.1M | −$75.7M | −$20.0M | −$1.9M | −$12.7M |
| Net profit margin | −139.81% | −140.35% | −123.61% | −170.58% | −230.67% | −1,088.94% | −584,144.44% | −6,707.18% | −245.16% | −11.07% | — |
| Basic EPSper basic share | -$3.19 | -$2.96 | -$3.55 | -$4.81 | -$4.96 | -$5.90 | -$5.12 | -$4.80 | -$2.14 | -$1.91 | -$5.88 |
| Diluted EPSper diluted share | -$3.19 | -$2.96 | -$3.55 | -$4.79 | -$4.96 | -$5.90 | -$5.12 | -$4.80 | -$2.14 | -$1.91 | -$5.88 |
Reported shareholders
| Holder | % owned |
|---|---|
RTW INVESTMENTS, LP | 9.30%4.54M shares |
BlackRock, Inc. | 6.55%3.2M shares |
MORGAN STANLEY | 5.27%2.58M shares |
Kynam Capital Management, LP | 4.98%2.43M shares |
Jefferies Financial Group Inc. | 4.50%2.2M shares |
SG Americas Securities, LLC | 4.20%2.05M shares |
AMERICAN CENTURY COMPANIES INC | 3.45%1.69M shares |
ACORN CAPITAL ADVISORS, LLC | 3.42%1.67M shares |
Point72 Asset Management, L.P. | 3.12%1.53M shares |
FRONTIER CAPITAL MANAGEMENT CO LLC | 3.09%1.51M shares |
Opaleye Management Inc. | 2.95%1.44M shares |
SILVERARC CAPITAL MANAGEMENT, LLC | 2.66%1.3M shares |
MENORA MIVTACHIM HOLDINGS LTD. | 2.36%1.15M shares |
D. E. Shaw & Co., Inc. | 2.34%1.15M shares |
STATE STREET CORP | 2.05%1M shares |
MPM BIOIMPACT LLC | 1.91%933.42K shares |
Soleus Capital Management, L.P. | 1.70%829.81K shares |
GOLDMAN SACHS GROUP INC | 1.68%819.83K shares |
Migdal Insurance & Financial Holdings Ltd. | 1.58%770.91K shares |
ORBIMED ADVISORS LLC | 1.38%676.19K shares |
Percentages use 48.87M shares of this listed class outstanding on Jun 30, 2026.
Gray completes the 100% scale. Reported positions may overlap; holders have different reporting dates.
| Transaction | Insider | Type | Shares | Price | Value | Owned after |
|---|---|---|---|---|---|---|
| Jun 22, 2026Form 4 · 10b5-1 | Schoenberg MarkChief Medical Officer | SellOrdinary Shares | 10.0K | $35.01 | $350.1K | 129.8K |
| Jun 8, 2026Form 4 | Schoenberg MarkChief Medical Officer | SellOrdinary Shares | 5.2K | $27.30 | $142.6K | 139.8K |
| May 8, 2026Form 4 · 10b5-1 | Schoenberg MarkChief Medical Officer | SellOrdinary Shares | 10.0K | $30.00 | $300.0K | 135.0K |
| Feb 3, 2026Form 4 | Smith Jason DrewGeneral Counsel | SellOrdinary Shares | 3.2K | $19.69 | $63.3K | 55.6K |
| Feb 3, 2026Form 4 | Smith Jason DrewGeneral Counsel | SellOrdinary Shares | 1.6K | $19.69 | $31.7K | 51.3K |