Revenue
2012
2013
2014
2015
2016
2017
2019
2020
2021
2022
2023
2024
2025
| 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | $7.5M | $0 | $0 | $9.4M | $18.4M | $32.2M | $6.8M | — | $311,000 | $1.8M | $15.6M | $28.4M | $27.4M | $14.3M |
| Research & development | $300.9M | $210.4M | $167.5M | $105.8M | $75.5M | $50.5M | $38.8M | $23.6M | $25.6M | $19.8M | $15.2M | $11.8M | $12.3M | $10.5M |
| Operating expenses | $380.6M | $279.3M | $214.1M | $138.6M | $97.4M | $63.5M | $49.6M | $38.0M | $32.9M | $26.6M | $24.9M | $17.3M | $17.6M | $17.5M |
| Operating income | −$373.1M | −$279.3M | −$214.1M | −$129.1M | −$79.0M | −$31.3M | −$42.8M | −$38.0M | −$32.6M | −$24.8M | −$9.4M | $11.1M | $9.7M | −$3.2M |
| Operating margin | −4,974.27% | — | — | −1,368.91% | −428.45% | −97.31% | −627.02% | — | −10,474.28% | −1,376.43% | −60.10% | 39.15% | 35.50% | −22.04% |
| EBITDA | −$370.5M | −$276.7M | −$212.0M | −$127.7M | −$78.1M | −$30.7M | −$42.4M | −$37.5M | −$31.9M | −$24.0M | −$8.3M | $11.8M | $10.4M | −$2.4M |
| EBITDA margin | −4,940.36% | — | — | −1,354.02% | −423.53% | −95.31% | −620.74% | — | −10,265.59% | −1,328.51% | −53.43% | 41.75% | 38.08% | −16.54% |
| Net income | −$345.9M | −$234.3M | −$182.4M | −$125.4M | −$78.9M | −$28.8M | −$41.6M | −$34.5M | −$30.7M | −$23.0M | −$15.8M | $13.0M | $12.0M | −$4.3M |
| Net profit margin | −4,612.13% | — | — | −1,328.95% | −427.85% | −89.65% | −609.09% | — | −9,872.67% | −1,275.49% | −101.12% | 45.89% | 43.98% | −30.06% |
| Basic EPSper basic share | -$4.36 | -$3.01 | -$2.73 | -$2.06 | -$1.77 | -$0.81 | -$1.54 | -$1.63 | -$1.71 | -$1.48 | -$1.10 | $4.11 | $2.87 | -$3.24 |
| Diluted EPSper diluted share | -$4.36 | -$3.01 | -$2.73 | -$2.06 | -$1.77 | -$0.81 | -$1.54 | -$1.63 | -$1.72 | -$1.48 | -$1.10 | $3.28 | $1.91 | -$3.24 |
Reported shareholders
| Holder | % owned |
|---|---|
FMR LLC | 9.97%9.65M shares |
BlackRock, Inc. | 7.77%7.52M shares |
Avoro Capital Advisors LLC | 5.97%5.78M shares |
Polar Capital Holdings Plc | 4.72%4.57M shares |
Driehaus Capital Management LLC | 4.57%4.42M shares |
Jupiter Topco LLC | 4.33%4.19M shares |
PRICE T ROWE ASSOCIATES INC /MD/ | 3.36%3.25M shares |
JPMORGAN CHASE & CO | 2.71%2.62M shares |
Capital International Investors | 2.44%2.36M shares |
T. Rowe Price Investment Management, Inc. | 2.24%2.17M shares |
STATE STREET CORP | 2.04%1.97M shares |
TWO SIGMA INVESTMENTS, LP | 1.70%1.64M shares |
DEERFIELD MANAGEMENT COMPANY, L.P. | 1.67%1.62M shares |
Affinity Asset Advisors, LLC | 1.65%1.6M shares |
ALLIANCEBERNSTEIN L.P. | 1.61%1.56M shares |
WESTFIELD CAPITAL MANAGEMENT CO LP | 1.56%1.51M shares |
FRANKLIN RESOURCES INC | 1.49%1.44M shares |
WELLINGTON MANAGEMENT GROUP LLP | 1.47%1.43M shares |
CITADEL ADVISORS LLC | 1.45%1.4M shares |
GEODE CAPITAL MANAGEMENT, LLC | 1.42%1.37M shares |
Percentages use 96.75M shares of this listed class outstanding on Jun 30, 2026.
Gray completes the 100% scale. Reported positions may overlap; holders have different reporting dates.
| Transaction | Insider | Type | Shares | Price | Value | Owned after |
|---|---|---|---|---|---|---|
| Jun 5, 2026Form 4 · 10b5-1 | PATOU GARYDirector | SellCommon Shares | 1.3K | $53.14 | $70.3K | 24.9K |
| Jun 5, 2026Form 4 · 10b5-1 | Cannon GillianDirector | SellCommon Shares | 1.2K | $53.14 | $63.2K | 1.5K |
| Mar 13, 2026Form 4 · 10b5-1 | KENNEY CHRISTOPHER JOHNChief Medical Officer | SellCommon Shares | 1.4K | $55.23 | $77.9K | 7.1K |
| Mar 13, 2026Form 4 · 10b5-1 | DiFabio AndreaChief Legal Officer | SellCommon Shares | 1.3K | $55.23 | $74.1K | 7.3K |
| Mar 13, 2026Form 4 · 10b5-1 | MORTIMER IANPRESIDENT & CEO | SellCommon Shares | 7.3K | $55.23 | $403.6K | 19.9K |
Xenon ($XENE) submitted a US new-drug application for azetukalner to treat focal seizures, supported by its X-TOLE and X-TOLE2 studies and more than 1,500 patient-years of exposure. Submission is an application milestone, not confirmation t ...