Alnylam Pharmaceuticals annual operating margin
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2025
Alnylam Pharmaceuticals Operating Margin Growth & History (ALNY)
Alnylam Pharmaceuticals's operating margin was 13.51% for fiscal 2025.
View full Alnylam Pharmaceuticals company overviewAlnylam Pharmaceuticals annual operating margin history
| Fiscal year | Period ended | Operating margin | Change (percentage points) |
|---|---|---|---|
| 2025 | 2025-12-31 | 13.51% | +21.37 pp |
| 2024 | 2024-12-31 | −7.87% | +7.57 pp |
| 2023 | 2023-12-31 | −15.43% | +60.24 pp |
| 2022 | 2022-12-31 | −75.68% | +8.26 pp |
| 2021 | 2021-12-31 | −83.93% | +84.16 pp |
| 2020 | 2020-12-31 | −168.09% | +259.41 pp |
| 2019 | 2019-12-31 | −427.50% | +660.06 pp |
| 2018 | 2018-12-31 | −1,087.56% | −531.37 pp |
| 2017 | 2017-12-31 | −556.20% | +344.13 pp |
| 2016 | 2016-12-31 | −900.33% | −856.28 pp |
| 2010 | 2010-12-31 | −44.05% | +3.80 pp |
| 2009 | 2009-12-31 | −47.86% | −18.91 pp |
| 2008 | 2008-12-31 | −28.95% | — |
Alnylam Pharmaceuticals quarterly operating margin
Q2.09
Q3.09
Q1.10
Q2.10
Q3.10
Q4.10
Q1.11
Q2.17
Q3.17
Q1.18
Q2.18
Q3.18
Q4.18
Q1.19
Q2.19
Q3.19
Q4.19
Q1.20
Q2.20
Q3.20
Q4.20
Q1.21
Q2.21
Q3.21
Q4.21
Q1.22
Q2.22
Q3.22
Q4.22
Q1.23
Q2.23
Q3.23
Q4.23
Q1.24
Q2.24
Q3.24
Q4.24
Q1.25
Q2.25
Q3.25
Q4.25
Q2.26
| Fiscal quarter | Period ended | Operating margin | Change (percentage points) |
|---|---|---|---|
| Q2 2026 | 2026-06-30 | 17.93% | +14.89 pp |
| Q4 2025 | 2025-12-31 | 12.01% | +29.74 pp |
| Q3 2025 | 2025-09-30 | 29.46% | +44.81 pp |
| Q2 2025 | 2025-06-30 | −2.09% | −9.46 pp |
| Q1 2025 | 2025-03-31 | 3.04% | +11.83 pp |
| Q4 2024 | 2024-12-31 | −17.73% | +8.74 pp |
| Q3 2024 | 2024-09-30 | −15.35% | −43.85 pp |
| Q2 2024 | 2024-06-30 | 7.37% | +79.47 pp |
| Q1 2024 | 2024-03-31 | −8.79% | +38.13 pp |
| Q4 2023 | 2023-12-31 | −26.47% | +29.82 pp |
| Q3 2023 | 2023-09-30 | 28.50% | +126.12 pp |
| Q2 2023 | 2023-06-30 | −72.10% | +13.16 pp |
| Q1 2023 | 2023-03-31 | −46.92% | +21.89 pp |
| Q4 2022 | 2022-12-31 | −56.30% | +18.96 pp |
| Q3 2022 | 2022-09-30 | −97.63% | −0.80 pp |
| Q2 2022 | 2022-06-30 | −85.26% | −18.99 pp |
| Q1 2022 | 2022-03-31 | −68.80% | +36.09 pp |
| Q4 2021 | 2021-12-31 | −75.26% | +43.49 pp |
| Q3 2021 | 2021-09-30 | −96.83% | +82.11 pp |
| Q2 2021 | 2021-06-30 | −66.27% | +125.01 pp |
| Q1 2021 | 2021-03-31 | −104.89% | +106.37 pp |
| Q4 2020 | 2020-12-31 | −118.75% | +297.09 pp |
| Q3 2020 | 2020-09-30 | −178.94% | +129.79 pp |
| Q2 2020 | 2020-06-30 | −191.28% | +337.12 pp |
| Q1 2020 | 2020-03-31 | −211.27% | +355.77 pp |
| Q4 2019 | 2019-12-31 | −415.83% | +631.84 pp |
| Q3 2019 | 2019-09-30 | −308.73% | +11994.70 pp |
| Q2 2019 | 2019-06-30 | −528.40% | +114.77 pp |
| Q1 2019 | 2019-03-31 | −567.03% | +106.08 pp |
| Q4 2018 | 2018-12-31 | −1,047.67% | −311.82 pp |
| Q3 2018 | 2018-09-30 | −12,303.43% | −11547.26 pp |
| Q2 2018 | 2018-06-30 | −643.17% | −568.16 pp |
| Q1 2018 | 2018-03-31 | −673.11% | −614.55 pp |
| Q3 2017 | 2017-09-30 | −735.84% | −704.30 pp |
| Q2 2017 | 2017-06-30 | −756.18% | −712.50 pp |
| Q1 2011 | 2011-03-31 | −75.02% | −28.99 pp |
| Q4 2010 | 2010-12-31 | −58.56% | −18.76 pp |
| Q3 2010 | 2010-09-30 | −31.55% | +59.56 pp |
| Q2 2010 | 2010-06-30 | −43.68% | — |
| Q1 2010 | 2010-03-31 | −46.03% | — |
| Q3 2009 | 2009-09-30 | −39.80% | — |
| Q2 2009 | 2009-06-30 | −91.10% | — |
Alnylam Pharmaceuticals operating margin trends
Over the last five reported fiscal years, Alnylam Pharmaceuticals's operating margin increased from −168.09% to 13.51%, a change of +181.60 percentage points. The latest reported quarter, Q2 2026, shows 17.93%.
About the metric
What operating margin means
Operating margin measures the percentage of revenue left after operating costs and expenses. It shows how much operating profit a company generates from each dollar of revenue.
Calculation and source
How operating margin is calculated
TickerStat calculates operating margin as SEC-reported operating income divided by SEC-reported revenue for the same fiscal period. Changes are shown in percentage points. Fiscal periods can differ from calendar years, so exact period-end dates are included.
Review Alnylam Pharmaceuticals filings at SEC.gov ↗