Revenue
2022
2023
2024
2025
| 2025 | 2024 | 2023 | 2022 | 2021 | 2019 | 2018 | 2017 | |
|---|---|---|---|---|---|---|---|---|
| Revenue | $3.72B | $3.12B | $2.39B | $2.09B | — | — | — | — |
| Gross profit | $3.48B | $2.98B | $2.36B | — | — | — | — | — |
| Gross margin | 93.60% | 95.42% | 98.62% | — | — | — | — | — |
| Research & development | $1.61B | $1.41B | $1.11B | — | — | — | — | — |
| Operating expenses | $2.65B | $2.15B | $1.62B | — | — | — | — | — |
| Operating income | $1.06B | $972.0M | $772.0M | $902.0M | — | — | — | — |
| Operating margin | 28.63% | 31.14% | 32.30% | 43.21% | — | — | — | — |
| EBITDA | $1.34B | $1.40B | $870.0M | $1.06B | — | — | — | — |
| EBITDA margin | 35.91% | 44.99% | 36.40% | 50.64% | — | — | — | — |
| Net income | $963.0M | $1.13B | $631.0M | $784.7M | $450.2M | — | — | — |
| Net profit margin | 25.89% | 36.30% | 26.40% | 37.59% | — | — | — | — |
| Basic EPSper basic share | $15.50 | $17.66 | $9.67 | $1.22 | — | — | — | — |
| Diluted EPSper diluted share | $15.37 | $17.53 | $9.58 | $1.20 | — | — | — | — |
Reported shareholders
Reported holdings Number of shares
| Holder | Shares held |
|---|---|
Paradigm Biocapital Advisors LP | 13.13M |
Orbis Allan Gray Ltd | 11.37M |
ALLIANCEBERNSTEIN L.P. | 8.64M |
DEERFIELD MANAGEMENT COMPANY, L.P. | 6.87M |
Deep Track Capital, LP | 5.65M |
ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 4.98M |
BlackRock, Inc. | 4.67M |
Sofinnova Investments, Inc. | 4.05M |
RENAISSANCE TECHNOLOGIES LLC | 3.52M |
TWO SIGMA INVESTMENTS, LP | 3.51M |
Harding Loevner LP | 3.09M |
FIRST TRUST ADVISORS LP | 2.76M |
CITADEL ADVISORS LLC | 2.48M |
Qube Research & Technologies Ltd | 1.69M |
MORGAN STANLEY | 1.63M |
FEDERATED HERMES, INC. | 1.45M |
GOLDMAN SACHS GROUP INC | 1.28M |
FRANKLIN RESOURCES INC | 1.2M |
Pictet Asset Management Holding SA | 1.07M |
UBS Group AG | 961.05K |
Bars compare reported share counts. A matching total for this share class and reporting period is unavailable, so percentages are not shown.