Revenue
2010
2011
2012
2013
2014
2015
2016
2017
2018
2019
2020
2021
2022
2023
2024
2025
| 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1999 | 1998 | 1997 | 1996 | 1995 | 1994 · Dec 31 | 1994 · Feb 28 | 1993 | 1992 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | $349.0M | $285.5M | $199.0M | $99.8M | $75.4M | $65.1M | $63.0M | $27.9M | $11.7M | $174.8M | $0 | $0 | $0 | $35,000 | $50,000 | $93,000 | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — |
| Gross profit | $322.2M | $268.1M | $178.1M | $83.8M | $58.6M | $50.1M | $43.0M | $8.5M | −$5.5M | $157.6M | −$64.7M | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — |
| Gross margin | 92.32% | 93.90% | 89.51% | 83.96% | 77.69% | 76.85% | 68.15% | 30.39% | −46.68% | 90.20% | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — |
| Research & development | $66.3M | $45.9M | $31.3M | $19.7M | $12.3M | $6.2M | $6.9M | $8.7M | $14.1M | $14.9M | $29.7M | $100.2M | $109.7M | $101.5M | $100.0M | $112.3M | $156.3M | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — |
| Operating expenses | $310.2M | $212.9M | $190.3M | $163.9M | $122.5M | $113.1M | $107.6M | $104.5M | $119.9M | $107.5M | $344.7M | $179.6M | $169.4M | $147.0M | $140.6M | $152.6M | $209.8M | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — |
| Operating income | $38.8M | $72.6M | $8.7M | −$64.1M | −$47.0M | −$47.9M | −$44.6M | −$76.6M | −$108.2M | $67.3M | −$344.7M | −$179.6M | −$169.4M | −$147.0M | −$140.5M | −$152.5M | −$209.8M | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — |
| Operating margin | 11.12% | 25.42% | 4.36% | −64.26% | −62.33% | −73.55% | −70.75% | −274.94% | −921.15% | 38.49% | — | — | — | −419,885.71% | −281,078.00% | −163,976.34% | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — |
| EBITDA | $51.1M | $80.0M | $13.2M | −$60.8M | −$45.0M | −$45.8M | −$43.6M | −$73.7M | −$106.4M | $69.7M | −$333.7M | −$169.8M | −$157.9M | −$134.0M | −$125.9M | −$136.0M | −$191.1M | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — |
| EBITDA margin | 14.64% | 28.01% | 6.64% | −60.93% | −59.70% | −70.25% | −69.20% | −264.68% | −905.82% | 39.86% | — | — | — | −382,742.86% | −251,878.00% | −146,234.41% | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — |
| Net income | $5.9M | $27.6M | −$11.9M | −$87.4M | −$80.9M | −$57.2M | −$51.9M | −$87.0M | −$117.3M | $125.7M | −$368.4M | −$198.4M | −$191.5M | −$169.4M | −$160.8M | −$170.6M | −$220.1M | −$303.0M | −$293.2M | −$230.5M | −$114.3M | −$76.0M | −$65.9M | −$206.3M | −$48.2M | −$24.7M | −$5.7M | −$3.3M | −$2.3M | −$2.6M | −$2.8M | −$2.0M | −$1.2M | −$1.2M | −$911,000 |
| Net profit margin | 1.68% | 9.66% | −6.00% | −87.60% | −107.27% | −87.87% | −82.34% | −312.20% | −999.00% | 71.91% | — | — | — | −483,902.86% | −321,608.00% | −183,397.85% | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — |
| Basic EPSper basic share | $0.02 | $0.10 | -$0.04 | -$0.34 | -$0.32 | -$0.26 | -$0.27 | -$0.60 | -$1.13 | $1.37 | -$4.54 | -$2.57 | -$3.20 | -$4.70 | -$6.60 | -$7.50 | -$10.35 | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — |
| Diluted EPSper diluted share | $0.02 | $0.10 | -$0.04 | -$0.34 | -$0.32 | -$0.26 | -$0.27 | -$0.60 | -$1.13 | $1.36 | -$4.54 | -$2.57 | -$3.20 | -$4.70 | -$6.60 | -$7.50 | -$10.35 | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — | — |
Reported shareholders
| Holder | % owned |
|---|---|
BlackRock, Inc. | 10.37%32.13M shares |
Rubric Capital Management LP | 5.81%18M shares |
STATE STREET CORP | 5.22%16.17M shares |
VANGUARD CAPITAL MANAGEMENT LLC | 4.25%13.17M shares |
GEODE CAPITAL MANAGEMENT, LLC | 2.56%7.95M shares |
WELLINGTON MANAGEMENT GROUP LLP | 2.53%7.84M shares |
Frazier Life Sciences Management, L.P. | 2.13%6.6M shares |
Deep Track Capital, LP | 1.94%6M shares |
180 WEALTH ADVISORS, LLC | 1.60%4.96M shares |
FMR LLC | 1.32%4.1M shares |
TSP Capital Management Group, LLC | 1.28%3.97M shares |
AQR CAPITAL MANAGEMENT LLC | 1.23%3.81M shares |
MORGAN STANLEY | 1.12%3.47M shares |
BRAIDWELL LP | 1.12%3.46M shares |
VANGUARD PORTFOLIO MANAGEMENT LLC | 0.97%3M shares |
NORTHERN TRUST CORP | 0.93%2.89M shares |
UBS Group AG | 0.93%2.89M shares |
TWO SIGMA INVESTMENTS, LP | 0.87%2.69M shares |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0.84%2.6M shares |
Castagna Michael | ≈0.79%2.44M shares |
Percentages use 309.91M shares of this listed class outstanding on Jun 30, 2026. ≈ compares the latest reported holding with a share total from a different date; it is not a confirmed current stake.
Gray completes the 100% scale. Reported positions may overlap; holders have different reporting dates.
| Transaction | Insider | Type | Shares | Price | Value | Owned after |
|---|---|---|---|---|---|---|
| May 12, 2026Form 4 · 10b5-1 | Binder Steven B.Director | SellCommon Stock, $0.01 Par Value | 16.9K | $3.29 | $55.7K | 808.0K |
| May 12, 2026Form 4 · 10b5-1 | Thomson DavidEVP Genl Counsel & Secretary | SellCommon Stock, $0.01 Par Value | 3.0K | $3.29 | $10.0K | 826.3K |
| Mar 10, 2026Form 4 | Castagna MichaelChief Executive Officer | BuyCommon Stock, $0.01 Par Value | 100.0K | $2.59 | $259.0K | 2.58M |
| Jan 8, 2026Form 4 · 10b5-1 | Tross Stuart AChief People & Workpl Officer | SellCommon Stock, $0.01 Par Value | 47.0K | $6.33 | $297.5K | 985.0K |
| Dec 17, 2025Form 4 · 10b5-1 | Castagna MichaelChief Executive Officer | SellCommon Stock, $0.01 Par Value | 65.8K | $6.01 | $395.5K | 2.50M |