Spyre Therapeutics annual operating expenses
2014
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2025
Spyre Therapeutics Operating Expenses Growth & History (SYRE)
Spyre Therapeutics's operating expenses was $209.6M for fiscal 2025.
View full Spyre Therapeutics company overviewSpyre Therapeutics annual operating expenses history
| Fiscal year | Period ended | Operating expenses | Change | Growth |
|---|---|---|---|---|
| 2025 | 2025-12-31 | $209.6M | $996,000 | +0.48% |
| 2024 | 2024-12-31 | $208.6M | −$34.6M | −14.24% |
| 2023 | 2023-12-31 | $243.2M | $156.1M | +179.17% |
| 2022 | 2022-12-31 | $87.1M | $2.7M | +3.23% |
| 2021 | 2021-12-31 | $84.4M | $2.9M | +3.57% |
| 2020 | 2020-12-31 | $81.5M | $1.1M | +1.43% |
| 2019 | 2019-12-31 | $80.3M | $31.0M | +62.78% |
| 2018 | 2018-12-31 | $49.4M | $16.5M | +50.09% |
| 2017 | 2017-12-31 | $32.9M | $6.3M | +23.92% |
| 2016 | 2016-12-31 | $26.5M | $9.1M | +52.49% |
| 2015 | 2015-12-31 | $17.4M | $8.5M | +95.42% |
| 2014 | 2014-12-31 | $8.9M | — | — |
Spyre Therapeutics quarterly operating expenses
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Q2.17
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Q3.18
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Q1.21
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Q3.24
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Q3.25
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Q1.26
Q2.26
| Fiscal quarter | Period ended | Operating expenses | Change | YoY change |
|---|---|---|---|---|
| Q2 2026 | 2026-06-30 | $41.6M | −$296,000 | −0.71% |
| Q1 2026 | 2026-03-31 | $45.6M | −$7.9M | −14.80% |
| Q4 2025 | 2025-12-31 | $57.2M | −$4.1M | −6.66% |
| Q3 2025 | 2025-09-30 | $56.9M | $1.5M | +2.70% |
| Q2 2025 | 2025-06-30 | $41.9M | −$2.2M | −5.01% |
| Q1 2025 | 2025-03-31 | $53.6M | $5.8M | +12.13% |
| Q4 2024 | 2024-12-31 | $61.3M | $15.3M | +33.41% |
| Q3 2024 | 2024-09-30 | $55.4M | $37.1M | +202.08% |
| Q2 2024 | 2024-06-30 | $44.1M | −$115.8M | −72.40% |
| Q1 2024 | 2024-03-31 | $47.8M | $28.8M | +151.39% |
| Q4 2023 | 2023-12-31 | $45.9M | $26.6M | +137.53% |
| Q3 2023 | 2023-09-30 | $18.3M | −$592,000 | −3.13% |
| Q2 2023 | 2023-06-30 | $159.9M | $136.9M | +593.92% |
| Q1 2023 | 2023-03-31 | $19.0M | −$6.8M | −26.35% |
| Q4 2022 | 2022-12-31 | $19.3M | −$4.8M | −19.75% |
| Q3 2022 | 2022-09-30 | $18.9M | −$2.8M | −12.74% |
| Q2 2022 | 2022-06-30 | $23.0M | $2.6M | +12.97% |
| Q1 2022 | 2022-03-31 | $25.8M | $7.6M | +41.70% |
| Q4 2021 | 2021-12-31 | $24.1M | $1.3M | +5.75% |
| Q3 2021 | 2021-09-30 | $21.7M | $3.6M | +19.69% |
| Q2 2021 | 2021-06-30 | $20.4M | −$1.2M | −5.38% |
| Q1 2021 | 2021-03-31 | $18.2M | −$813,000 | −4.27% |
| Q4 2020 | 2020-12-31 | $22.8M | $867,000 | +3.96% |
| Q3 2020 | 2020-09-30 | $18.1M | −$4.0M | −18.17% |
| Q2 2020 | 2020-06-30 | $21.6M | $2.9M | +15.78% |
| Q1 2020 | 2020-03-31 | $19.0M | $1.4M | +7.73% |
| Q4 2019 | 2019-12-31 | $21.9M | $6.6M | +43.15% |
| Q3 2019 | 2019-09-30 | $22.1M | $9.9M | +80.89% |
| Q2 2019 | 2019-06-30 | $18.6M | $6.6M | +54.57% |
| Q1 2019 | 2019-03-31 | $17.7M | $7.9M | +81.00% |
| Q4 2018 | 2018-12-31 | $15.3M | $7.2M | +88.72% |
| Q3 2018 | 2018-09-30 | $12.2M | $3.0M | +32.23% |
| Q2 2018 | 2018-06-30 | $12.0M | $3.8M | +46.94% |
| Q1 2018 | 2018-03-31 | $9.8M | $2.4M | +33.39% |
| Q4 2017 | 2017-12-31 | $8.1M | $1.3M | +19.44% |
| Q3 2017 | 2017-09-30 | $9.3M | $1.8M | +24.28% |
| Q2 2017 | 2017-06-30 | $8.2M | $1.3M | +19.38% |
| Q1 2017 | 2017-03-31 | $7.3M | $1.9M | +34.78% |
| Q4 2016 | 2016-12-31 | $6.8M | $1.2M | +21.64% |
| Q3 2016 | 2016-09-30 | $7.5M | $3.0M | +65.92% |
| Q2 2016 | 2016-06-30 | $6.9M | $2.0M | +41.35% |
| Q1 2016 | 2016-03-31 | $5.4M | $3.0M | +119.77% |
| Q4 2015 | 2015-12-31 | $5.6M | — | — |
| Q3 2015 | 2015-09-30 | $4.5M | — | — |
| Q2 2015 | 2015-06-30 | $4.9M | — | — |
| Q1 2015 | 2015-03-31 | $2.5M | — | — |
Spyre Therapeutics operating expenses trends
Over the last five fiscal years, Spyre Therapeutics's operating expenses increased from $81.5M to $209.6M, a change of $128.1M. The latest reported quarter, Q2 2026, shows $41.6M.
About the metric
What operating expenses mean
Operating expenses are the recurring costs of running a company’s business beyond the direct costs used to calculate gross profit. They commonly include selling, general and administrative expenses, research and development, and other operating costs.
Calculation and source
SEC-reported and calculated operating expenses
TickerStat uses operating expenses reported in company SEC filings when available. When a separate total is unavailable, it calculates operating expenses as aligned gross profit minus operating income for the same fiscal period. Fiscal periods can differ from calendar years, so exact period-end dates are included.
Review Spyre Therapeutics source filings ↗