Spyre Therapeutics annual operating income
2014
2015
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2021
2022
2023
2024
2025
Spyre Therapeutics Operating Income Growth & History (SYRE)
Spyre Therapeutics's operating income was −$209.6M for fiscal 2025.
View full Spyre Therapeutics company overviewSpyre Therapeutics annual operating income history
| Fiscal year | Period ended | Operating income | Change | Growth |
|---|---|---|---|---|
| 2025 | 2025-12-31 | −$209.6M | −$996,000 | — |
| 2024 | 2024-12-31 | −$208.6M | $33.7M | — |
| 2023 | 2023-12-31 | −$242.3M | −$157.5M | — |
| 2022 | 2022-12-31 | −$84.8M | −$19.1M | — |
| 2021 | 2021-12-31 | −$65.6M | $15.8M | — |
| 2020 | 2020-12-31 | −$81.5M | −$1.1M | — |
| 2019 | 2019-12-31 | −$80.3M | −$34.9M | — |
| 2018 | 2018-12-31 | −$45.5M | −$17.8M | — |
| 2017 | 2017-12-31 | −$27.7M | −$5.8M | — |
| 2016 | 2016-12-31 | −$21.9M | −$10.6M | — |
| 2015 | 2015-12-31 | −$11.3M | −$2.4M | — |
| 2014 | 2014-12-31 | −$8.9M | — | — |
Spyre Therapeutics quarterly operating income
Q1.15
Q2.15
Q3.15
Q4.15
Q1.16
Q2.16
Q3.16
Q4.16
Q1.17
Q2.17
Q3.17
Q4.17
Q1.18
Q2.18
Q3.18
Q4.18
Q1.19
Q2.19
Q3.19
Q4.19
Q1.20
Q2.20
Q3.20
Q4.20
Q1.21
Q2.21
Q3.21
Q4.21
Q1.22
Q2.22
Q3.22
Q4.22
Q1.23
Q2.23
Q3.23
Q4.23
Q1.24
Q2.24
Q3.24
Q4.24
Q1.25
Q2.25
Q3.25
Q4.25
Q1.26
Q2.26
| Fiscal quarter | Period ended | Operating income | Change | YoY change |
|---|---|---|---|---|
| Q2 2026 | 2026-06-30 | −$41.6M | $296,000 | — |
| Q1 2026 | 2026-03-31 | −$45.6M | $7.9M | — |
| Q4 2025 | 2025-12-31 | −$57.2M | $4.1M | — |
| Q3 2025 | 2025-09-30 | −$56.9M | −$1.5M | — |
| Q2 2025 | 2025-06-30 | −$41.9M | $2.2M | — |
| Q1 2025 | 2025-03-31 | −$53.6M | −$5.8M | — |
| Q4 2024 | 2024-12-31 | −$61.3M | −$15.3M | — |
| Q3 2024 | 2024-09-30 | −$55.4M | −$37.1M | — |
| Q2 2024 | 2024-06-30 | −$44.1M | $115.1M | — |
| Q1 2024 | 2024-03-31 | −$47.8M | −$29.0M | — |
| Q4 2023 | 2023-12-31 | −$45.9M | −$26.8M | — |
| Q3 2023 | 2023-09-30 | −$18.3M | $418,000 | — |
| Q2 2023 | 2023-06-30 | −$159.2M | −$136.8M | — |
| Q1 2023 | 2023-03-31 | −$18.8M | $5.6M | — |
| Q4 2022 | 2022-12-31 | −$19.2M | $1.3M | — |
| Q3 2022 | 2022-09-30 | −$18.8M | $1.5M | — |
| Q2 2022 | 2022-06-30 | −$22.4M | −$15.7M | — |
| Q1 2022 | 2022-03-31 | −$24.4M | −$6.2M | — |
| Q4 2021 | 2021-12-31 | −$20.4M | $2.3M | — |
| Q3 2021 | 2021-09-30 | −$20.3M | −$2.2M | — |
| Q2 2021 | 2021-06-30 | −$6.7M | $14.9M | — |
| Q1 2021 | 2021-03-31 | −$18.2M | $813,000 | — |
| Q4 2020 | 2020-12-31 | −$22.8M | −$867,000 | — |
| Q3 2020 | 2020-09-30 | −$18.1M | $4.0M | — |
| Q2 2020 | 2020-06-30 | −$21.6M | −$2.9M | — |
| Q1 2020 | 2020-03-31 | −$19.0M | −$1.4M | — |
| Q4 2019 | 2019-12-31 | −$21.9M | −$6.6M | — |
| Q3 2019 | 2019-09-30 | −$22.1M | −$9.9M | — |
| Q2 2019 | 2019-06-30 | −$18.6M | −$9.0M | — |
| Q1 2019 | 2019-03-31 | −$17.7M | −$9.4M | — |
| Q4 2018 | 2018-12-31 | −$15.3M | −$8.7M | — |
| Q3 2018 | 2018-09-30 | −$12.2M | −$4.2M | — |
| Q2 2018 | 2018-06-30 | −$9.7M | −$3.0M | — |
| Q1 2018 | 2018-03-31 | −$8.2M | −$1.9M | — |
| Q4 2017 | 2017-12-31 | −$6.6M | −$1.1M | — |
| Q3 2017 | 2017-09-30 | −$8.0M | −$1.7M | — |
| Q2 2017 | 2017-06-30 | −$6.7M | −$1.2M | — |
| Q1 2017 | 2017-03-31 | −$6.3M | −$1.8M | — |
| Q4 2016 | 2016-12-31 | −$5.5M | −$1.5M | — |
| Q3 2016 | 2016-09-30 | −$6.3M | −$2.9M | — |
| Q2 2016 | 2016-06-30 | −$5.5M | −$4.1M | — |
| Q1 2016 | 2016-03-31 | −$4.6M | −$2.1M | — |
| Q4 2015 | 2015-12-31 | −$4.0M | — | — |
| Q3 2015 | 2015-09-30 | −$3.4M | — | — |
| Q2 2015 | 2015-06-30 | −$1.4M | — | — |
| Q1 2015 | 2015-03-31 | −$2.5M | — | — |
Spyre Therapeutics operating income trends
Over the last five fiscal years, Spyre Therapeutics's operating income decreased from −$81.5M to −$209.6M, a change of −$128.1M. The latest reported quarter, Q2 2026, shows −$41.6M.
About the metric
What operating income means
Operating income is the profit or loss a company generates from its core business after cost of revenue and operating expenses, but before non-operating items such as interest and income taxes.
Calculation and source
SEC-reported operating income
TickerStat standardizes operating income reported in company SEC filings for aligned fiscal periods. It is not adjusted EBIT, an analyst estimate, or company guidance. Fiscal periods can differ from calendar years, so exact period-end dates are included.
Review Spyre Therapeutics source filings ↗