Revenue
2022
2023
2024
2025
Upstream Bio, Inc. (UPB)
Price$6.09Cached quote
Net income
2022
2023
2024
2025
Free cash flow
2022
2023
2024
2025
Total cash / debt
CashTotal debt
2022
2023
2024
2025
Financial statements
| 2025 | 2024 | 2023 | 2022 | |
|---|---|---|---|---|
| Revenue | $2.9M | $2.4M | $2.4M | $1.2M |
| Research & development | $136.8M | $63.0M | $31.8M | $18.7M |
| Operating expenses | $163.2M | $80.1M | $42.5M | $25.1M |
| Operating income | −$160.4M | −$77.8M | −$40.1M | −$23.9M |
| Operating margin | −5,618.82% | −3,281.18% | −1,685.46% | −1,972.69% |
| EBITDA | −$160.2M | −$77.7M | −$40.1M | −$23.9M |
| EBITDA margin | −5,612.23% | −3,277.43% | −1,682.94% | −1,972.11% |
| Net income | −$143.4M | −$62.8M | −$20.5M | −$23.9M |
| Net profit margin | −5,026.03% | −2,650.04% | −862.90% | −1,969.31% |
| Basic EPSper basic share | -$2.66 | -$5.58 | -$12.95 | -$0.66 |
| Diluted EPSper diluted share | -$2.66 | -$5.58 | -$12.95 | -$0.66 |
Owners
Reported shareholders
14.90%of listed shares
FMR LLC8.16M shares · Jun 30, 2026
View holders
| Holder | % owned |
|---|---|
FMR LLC | 14.90%8.16M shares |
ORBIMED ADVISORS LLC | 10.40%5.69M shares |
Chimovits Erez | ≈10.40%5.69M shares |
Access Industries Holdings LLC / Blavatnik Len / AI Upstream LLC / ACCESS INDUSTRIES MANAGEMENT, LLC / AI Biotechnology LLC | ≈10.03%5.49M shares |
NORGES BANK | 6.88%3.77M shares |
BlackRock, Inc. | 6.85%3.75M shares |
Decheng Capital LLC | 4.98%2.72M shares |
ENAVATE SCIENCES GP, LLC | 4.49%2.46M shares |
VANGUARD CAPITAL MANAGEMENT LLC | 3.43%1.88M shares |
MILLENNIUM MANAGEMENT LLC | 2.09%1.14M shares |
D. E. Shaw & Co., Inc. | 1.89%1.04M shares |
JPMORGAN CHASE & CO | 1.85%1.01M shares |
Qube Research & Technologies Ltd | 1.79%978.5K shares |
Parkman Healthcare Partners LLC | 1.71%935.25K shares |
GEODE CAPITAL MANAGEMENT, LLC | 1.70%931.26K shares |
Wellington Biomedical Innovation Master Investors (Cayman) II L.P. | ≈1.63%894.73K shares |
SEB Asset Management AB | 1.60%878.47K shares |
Woodline Partners LP | 1.52%831.48K shares |
STATE STREET CORP | 1.40%766.32K shares |
VANGUARD PORTFOLIO MANAGEMENT LLC | 1.30%712.67K shares |
Percentages use 54.77M shares of this listed class outstanding on Jun 30, 2026. ≈ compares the latest reported holding with a share total from a different date; it is not a confirmed current stake.
Gray completes the 100% scale. Reported positions may overlap; holders have different reporting dates.
Source: SEC Form 13F ↗Updated Sep 29, 2026 · Quarterly data
Insider buys & sells
| Transaction | Insider | Type | Shares | Price | Value | Owned after |
|---|---|---|---|---|---|---|
| Jun 16, 2026Form 4 | GRAY MICHAELCFO and COO | SellCommon Stock | 853 | $6.10 | $5.2K | 28.8K |
| Jun 16, 2026Form 4 | Sutherland Everett RandChief Executive Officer | SellCommon Stock | 2.1K | $6.10 | $12.8K | 70.8K |
| Jun 16, 2026Form 4 | Houghton AdamChief Business Officer | SellCommon Stock | 700 | $6.10 | $4.3K | 23.6K |
| Jun 16, 2026Form 4 | Deykin AaronChief Medical Officer | SellCommon Stock | 895 | $6.10 | $5.5K | 33.2K |
| Jun 16, 2026Form 4 | Ambrose AllisonGeneral Counsel | SellCommon Stock | 477 | $6.10 | $2.9K | 16.0K |