Upstream Bio annual operating margin
2022
2023
2024
2025
Upstream Bio Operating Margin Growth & History (UPB)
Upstream Bio's operating margin was −5,618.82% for fiscal 2025.
View full Upstream Bio company overviewUpstream Bio annual operating margin history
| Fiscal year | Period ended | Operating margin | Change (percentage points) |
|---|---|---|---|
| 2025 | 2025-12-31 | −5,618.82% | −2337.63 pp |
| 2024 | 2024-12-31 | −3,281.18% | −1595.72 pp |
| 2023 | 2023-12-31 | −1,685.46% | +287.23 pp |
| 2022 | 2022-12-31 | −1,972.69% | — |
Upstream Bio quarterly operating margin
Q3.23
Q1.24
Q2.24
Q3.24
Q4.24
Q1.25
Q2.25
Q3.25
Q4.25
Q1.26
Q2.26
| Fiscal quarter | Period ended | Operating margin | Change (percentage points) |
|---|---|---|---|
| Q2 2026 | 2026-06-30 | −5,480.98% | −748.11 pp |
| Q1 2026 | 2026-03-31 | −4,218.09% | +1437.92 pp |
| Q4 2025 | 2025-12-31 | −6,911.23% | −2617.92 pp |
| Q3 2025 | 2025-09-30 | −5,539.39% | −2426.86 pp |
| Q2 2025 | 2025-06-30 | −4,732.87% | −1293.66 pp |
| Q1 2025 | 2025-03-31 | −5,656.01% | −3310.23 pp |
| Q4 2024 | 2024-12-31 | −4,293.31% | — |
| Q3 2024 | 2024-09-30 | −3,112.52% | −1601.09 pp |
| Q2 2024 | 2024-06-30 | −3,439.22% | — |
| Q1 2024 | 2024-03-31 | −2,345.78% | — |
| Q3 2023 | 2023-09-30 | −1,511.43% | — |
Upstream Bio operating margin trends
Between the periods ended 2022-12-31 and 2025-12-31, Upstream Bio's operating margin decreased from −1,972.69% to −5,618.82%, a change of −3646.13 percentage points. The latest reported quarter, Q2 2026, shows −5,480.98%.
About the metric
What operating margin means
Operating margin measures the percentage of revenue left after operating costs and expenses. It shows how much operating profit a company generates from each dollar of revenue.
Calculation and source
How operating margin is calculated
TickerStat calculates operating margin as SEC-reported operating income divided by SEC-reported revenue for the same fiscal period. Changes are shown in percentage points. Fiscal periods can differ from calendar years, so exact period-end dates are included.
Review Upstream Bio source filings ↗