Upstream Bio annual net profit margin
2022
2023
2024
2025
Upstream Bio Net Profit Margin Growth & History (UPB)
Upstream Bio's net profit margin was −5,026.03% for fiscal 2025.
View full Upstream Bio company overviewUpstream Bio annual net profit margin history
| Fiscal year | Period ended | Net profit margin | Change (percentage points) |
|---|---|---|---|
| 2025 | 2025-12-31 | −5,026.03% | −2375.99 pp |
| 2024 | 2024-12-31 | −2,650.04% | −1787.14 pp |
| 2023 | 2023-12-31 | −862.90% | +1106.41 pp |
| 2022 | 2022-12-31 | −1,969.31% | — |
Upstream Bio quarterly net profit margin
Q3.23
Q1.24
Q2.24
Q3.24
Q4.24
Q1.25
Q2.25
Q3.25
Q4.25
Q1.26
Q2.26
| Fiscal quarter | Period ended | Net profit margin | Change (percentage points) |
|---|---|---|---|
| Q2 2026 | 2026-06-30 | −5,136.09% | −870.78 pp |
| Q1 2026 | 2026-03-31 | −3,925.63% | +892.39 pp |
| Q4 2025 | 2025-12-31 | −6,356.14% | −2890.88 pp |
| Q3 2025 | 2025-09-30 | −4,941.14% | −2306.55 pp |
| Q2 2025 | 2025-06-30 | −4,265.31% | −1387.28 pp |
| Q1 2025 | 2025-03-31 | −4,818.02% | −3115.83 pp |
| Q4 2024 | 2024-12-31 | −3,465.25% | — |
| Q3 2024 | 2024-09-30 | −2,634.60% | −2135.08 pp |
| Q2 2024 | 2024-06-30 | −2,878.04% | — |
| Q1 2024 | 2024-03-31 | −1,702.19% | — |
| Q3 2023 | 2023-09-30 | −499.52% | — |
Upstream Bio net profit margin trends
Between the periods ended 2022-12-31 and 2025-12-31, Upstream Bio's net profit margin decreased from −1,969.31% to −5,026.03%, a change of −3056.73 percentage points. The latest reported quarter, Q2 2026, shows −5,136.09%.
About the metric
What net profit margin means
Net profit margin measures the percentage of revenue remaining as net income after operating costs, interest, taxes, and other expenses. It shows how much bottom-line profit or loss a company generates from each dollar of revenue.
Calculation and source
How net profit margin is calculated
TickerStat calculates net profit margin as SEC-reported net income divided by SEC-reported revenue for the same fiscal period. Changes are shown in percentage points. Fiscal periods can differ from calendar years, so exact period-end dates are included.
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