Revenue
2014
2015
2016
2017
2018
2019
2020
2021
2022
2023
2024
2025
| 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | $16.1M | $27.1M | $15.8M | $106.5M | $524.0M | $37.5M | $7.3M | $11.3M | $13.1M | $25.1M | $10.6M | $6.1M |
| Gross profit | $14.4M | $25.9M | $15.8M | $105.2M | $499.0M | $34.6M | $5.6M | $10.1M | $12.3M | $23.8M | — | — |
| Gross margin | 89.53% | 95.33% | 99.59% | 98.82% | 95.23% | 92.27% | 77.28% | 89.35% | 93.77% | 94.63% | — | — |
| Research & development | $140.7M | $143.8M | $214.9M | $197.6M | $143.5M | $122.4M | $94.7M | $74.8M | $72.2M | $72.5M | $59.1M | $43.8M |
| Operating expenses | $199.8M | $210.1M | $289.5M | $252.7M | $199.8M | $165.0M | $128.3M | $100.1M | $96.8M | $98.5M | $82.5M | $60.8M |
| Operating income | −$185.3M | −$184.3M | −$282.9M | −$143.2M | $310.6M | −$125.4M | −$121.1M | −$88.2M | −$71.3M | −$71.9M | −$71.2M | −$53.7M |
| Operating margin | −1,151.38% | −679.58% | −1,785.46% | −134.44% | 59.28% | −334.34% | −1,663.78% | −781.92% | −544.31% | −286.66% | −672.63% | −874.16% |
| EBITDA | −$170.6M | −$171.7M | −$271.0M | −$134.6M | $317.9M | −$114.8M | −$114.5M | −$75.8M | −$63.8M | −$66.4M | −$66.8M | −$51.7M |
| EBITDA margin | −1,059.70% | −632.96% | −1,710.35% | −126.43% | 60.67% | −305.96% | −1,572.19% | −671.90% | −486.76% | −264.75% | −631.04% | −841.59% |
| Net income | −$199.0M | −$239.6M | −$308.5M | −$126.8M | $329.6M | −$125.0M | −$124.2M | −$83.3M | −$79.3M | −$73.4M | −$82.1M | — |
| Net profit margin | −1,236.00% | −883.35% | −1,947.09% | −119.07% | 62.90% | −333.27% | −1,705.82% | −738.25% | −604.72% | −292.35% | −775.98% | — |
| Basic EPSper basic share | -$3.46 | -$4.92 | -$6.47 | -$2.71 | $7.17 | -$2.81 | -$3.11 | -$2.34 | -$2.94 | -$2.93 | -$3.72 | -$2.91 |
| Diluted EPSper diluted share | -$3.46 | -$4.92 | -$6.47 | -$2.71 | $7.04 | -$2.81 | -$3.11 | -$2.34 | -$2.94 | -$2.93 | -$3.72 | -$2.91 |
Reported shareholders
| Holder | % owned |
|---|---|
Avoro Capital Advisors LLC | 9.70%6.73M shares |
JPMORGAN CHASE & CO | 7.02%4.87M shares |
RTW INVESTMENTS, LP | 5.68%3.94M shares |
STATE STREET CORP | 4.19%2.9M shares |
Aberdeen Group plc | 4.11%2.85M shares |
BlackRock, Inc. | 2.71%1.88M shares |
ORBIMED ADVISORS LLC | 2.61%1.81M shares |
JANE STREET GROUP, LLC | 2.32%1.61M shares |
JENNISON ASSOCIATES LLC | 2.25%1.56M shares |
Boxer Capital Management, LLC | 2.17%1.5M shares |
GOLDMAN SACHS GROUP INC | 2.13%1.48M shares |
TWO SIGMA INVESTMENTS, LP | 2.11%1.46M shares |
Two Seas Capital LP | 2.08%1.44M shares |
FMR LLC | 1.83%1.27M shares |
MAK CAPITAL ONE LLC | 1.78%1.23M shares |
MPM BIOIMPACT LLC | 1.77%1.23M shares |
MORGAN STANLEY | 1.54%1.07M shares |
Assenagon Asset Management S.A. | 1.48%1.03M shares |
Vestal Point Capital, LP | 1.35%935K shares |
MAVERICK CAPITAL LTD | 1.33%925.38K shares |
Percentages use 69.33M shares of this listed class outstanding on Jun 30, 2026.
Gray completes the 100% scale. Reported positions may overlap; holders have different reporting dates.
| Transaction | Insider | Type | Shares | Price | Value | Owned after |
|---|---|---|---|---|---|---|
| Jun 26, 2026Form 4 | Abi-Saab WalidChief Medical Officer | SellOrdinary Shares | 1.4K | $46.86 | $67.2K | 168.2K |
| Jun 25, 2026Form 4 · 10b5-1 | Kapusta Matthew CCEO, Managing Director | SellOrdinary Shares | 28.7K | $50.02 | $1.44M | 519.2K |
| Jun 24, 2026Form 4 · 10b5-1 | Kapusta Matthew CCEO, Managing Director | SellOrdinary Shares | 6.7K | $50.00 | $334.8K | 519.2K |
| Jun 18, 2026Form 4 · 10b5-1 | Kapusta Matthew CCEO, Managing Director | SellOrdinary Shares | 37.0K | $50.00 | $1.85M | 521.8K |
| Jun 18, 2026Form 4 · 10b5-1 | Kapusta Matthew CCEO, Managing Director | SellOrdinary Shares | 4.7K | $50.00 | $232.8K | 558.8K |
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