Revenue
2013
2014
2015
2016
2017
2018
2019
2020
2021
2022
2023
2024
2025
| 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | $170.4M | $83.3M | $90.2M | $112.7M | $470.3M | $154.6M | $35.2M | $218.5M | $10.4M | $4.6M | $7.6M | $6.1M | $6.1M |
| Gross profit | $150.1M | $49.8M | $53.0M | $58.2M | $418.5M | $118.9M | $27.0M | $208.9M | $8.7M | $4.5M | $7.5M | $6.0M | $5.9M |
| Gross margin | 88.09% | 59.72% | 58.76% | 51.61% | 88.98% | 76.89% | 76.61% | 95.59% | 83.56% | 97.86% | 98.71% | 98.01% | 97.16% |
| Research & development | $228.3M | $208.5M | $232.3M | $242.5M | $181.4M | $166.3M | $124.2M | $83.9M | $57.2M | $45.5M | $17.3M | $5.0M | $5.1M |
| Operating expenses | $331.6M | $316.7M | $358.4M | $375.6M | $310.4M | $273.8M | $184.2M | $130.4M | $86.3M | $69.9M | $30.7M | $9.8M | $10.9M |
| Operating income | −$161.2M | −$233.3M | −$268.1M | −$262.9M | $160.0M | −$119.2M | −$149.0M | $88.1M | −$75.9M | −$65.3M | −$23.1M | −$3.7M | −$4.8M |
| Operating margin | −94.58% | −280.03% | −297.12% | −233.20% | 34.01% | −77.14% | −422.89% | 40.32% | −730.15% | −1,423.84% | −304.92% | −60.16% | −78.46% |
| EBITDA | −$145.6M | −$217.1M | −$250.8M | −$250.0M | $169.5M | −$110.8M | −$141.8M | $92.1M | −$73.2M | −$64.8M | −$23.1M | −$3.7M | −$4.8M |
| EBITDA margin | −85.42% | −260.57% | −277.93% | −221.75% | 36.05% | −71.70% | −402.59% | 42.14% | −704.31% | −1,411.99% | −303.86% | −60.16% | −78.46% |
| Net income | −$193.9M | −$227.1M | −$263.5M | −$280.3M | $127.8M | −$111.3M | −$94.7M | $99.9M | −$73.2M | −$63.0M | −$22.8M | −$4.0M | −$5.4M |
| Net profit margin | −113.75% | −272.54% | −291.99% | −248.68% | 27.18% | −71.98% | −268.88% | 45.74% | −704.02% | −1,372.13% | −300.62% | −65.41% | −88.50% |
| Basic EPSper basic share | -$3.76 | -$4.59 | -$6.02 | -$6.50 | $3.01 | -$2.98 | -$2.58 | $2.99 | -$2.45 | -$2.38 | -$2.59 | -$1.82 | -$2.50 |
| Diluted EPSper diluted share | -$3.76 | -$4.59 | -$6.02 | -$6.50 | $2.91 | -$2.98 | -$2.58 | $2.73 | -$2.45 | -$2.38 | -$2.59 | -$1.82 | -$2.50 |
Reported shareholders
| Holder | % owned |
|---|---|
BlackRock, Inc. | 11.81%6.4M shares |
Redmile Group, LLC | 8.07%4.37M shares |
STATE STREET CORP | 5.49%2.97M shares |
Fox Allan M. | ≈5.38%2.91M shares |
JPMORGAN CHASE & CO | 4.09%2.21M shares |
VANGUARD CAPITAL MANAGEMENT LLC | 3.89%2.11M shares |
MORGAN STANLEY | 3.61%1.95M shares |
GOLDMAN SACHS GROUP INC | 2.62%1.42M shares |
AQR CAPITAL MANAGEMENT LLC | 2.54%1.38M shares |
VANGUARD PORTFOLIO MANAGEMENT LLC | 2.50%1.36M shares |
MARSHALL WACE, LLP | 2.37%1.28M shares |
GEODE CAPITAL MANAGEMENT, LLC | 2.29%1.24M shares |
Integral Health Asset Management, LLC | 1.48%800K shares |
Nuveen, LLC | 1.37%740.03K shares |
DIMENSIONAL FUND ADVISORS LP | 1.35%731.59K shares |
D. E. Shaw & Co., Inc. | 1.32%712.81K shares |
TWO SIGMA INVESTMENTS, LP | 1.24%669.81K shares |
CITADEL ADVISORS LLC | 1.24%669.02K shares |
STIFEL FINANCIAL CORP | 1.04%560.73K shares |
BANK OF AMERICA CORP /DE/ | 0.96%518.55K shares |
Percentages use 54.16M shares of this listed class outstanding on Jun 30, 2026. ≈ compares the latest reported holding with a share total from a different date; it is not a confirmed current stake.
Gray completes the 100% scale. Reported positions may overlap; holders have different reporting dates.
| Transaction | Insider | Type | Shares | Price | Value | Owned after |
|---|---|---|---|---|---|---|
| May 11, 2026Form 4 · 10b5-1 | PAKOLA STEVEChief Medical Officer | SellCommon Stock | 15.3K | $11.02 | $168.7K | 232.6K |
| Mar 10, 2026Form 4 · 10b5-1 | PAKOLA STEVEChief Medical Officer | SellCommon Stock | 5.1K | $10.35 | $53.0K | 247.9K |
| Oct 9, 2025Form 4 · 10b5-1 | Simpson CurranChief Executive Officer | SellCommon Stock | 20.8K | $12.62 | $262.6K | 216.2K |
| Sep 29, 2025Form 4 · 10b5-1 | Simpson CurranChief Executive Officer | SellCommon Stock | 7.6K | $10.03 | $76.5K | 237.0K |
| Sep 10, 2025Form 4 · 10b5-1 | Simpson CurranChief Executive Officer | SellCommon Stock | 7.7K | $10.02 | $77.5K | 244.6K |
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