Ionis Pharmaceuticals annual return on equity
2009
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2011
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2015
2016
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2018
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2020
2021
2022
2023
2024
2025
Ionis Pharmaceuticals Return on Equity (ROE) Growth & History (IONS)
Ionis Pharmaceuticals's return on equity was −70.80% for fiscal 2025.
View full Ionis Pharmaceuticals company overviewIonis Pharmaceuticals annual return on equity history
| Fiscal year | Period ended | Return on equity | Change (percentage points) |
|---|---|---|---|
| 2025 | 2025-12-31 | −70.80% | +22.31 pp |
| 2024 | 2024-12-31 | −93.10% | −16.76 pp |
| 2023 | 2023-12-31 | −76.34% | −36.22 pp |
| 2022 | 2022-12-31 | −40.12% | −36.34 pp |
| 2021 | 2021-12-31 | −3.78% | +36.35 pp |
| 2020 | 2020-12-31 | −40.13% | −62.21 pp |
| 2019 | 2019-12-31 | 22.08% | −19.11 pp |
| 2018 | 2018-12-31 | 41.19% | +41.01 pp |
| 2017 | 2017-12-31 | 0.18% | +40.40 pp |
| 2016 | 2016-12-31 | −40.22% | −1.72 pp |
| 2015 | 2015-12-31 | −38.50% | −26.25 pp |
| 2014 | 2014-12-31 | −12.26% | +9.36 pp |
| 2013 | 2013-12-31 | −21.61% | +15.36 pp |
| 2012 | 2012-12-31 | −36.97% | +3.80 pp |
| 2011 | 2011-12-31 | −40.77% | −17.93 pp |
| 2010 | 2010-12-31 | −22.84% | −93.47 pp |
| 2009 | 2009-12-31 | 70.63% | — |
Ionis Pharmaceuticals quarterly return on equity
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| Fiscal quarter | Period ended | Return on equity | Change (percentage points) |
|---|---|---|---|
| Q2 2026 | 2026-06-30 | −24.62% | −46.94 pp |
| Q1 2026 | 2026-03-31 | −18.87% | +8.74 pp |
| Q4 2025 | 2025-12-31 | −41.44% | −24.76 pp |
| Q3 2025 | 2025-09-30 | −20.58% | +9.75 pp |
| Q2 2025 | 2025-06-30 | 22.31% | +45.97 pp |
| Q1 2025 | 2025-03-31 | −27.62% | +14.19 pp |
| Q4 2024 | 2024-12-31 | −16.68% | −14.05 pp |
| Q3 2024 | 2024-09-30 | −30.34% | +9.30 pp |
| Q2 2024 | 2024-06-30 | −23.66% | −5.01 pp |
| Q1 2024 | 2024-03-31 | −41.80% | −18.33 pp |
| Q4 2023 | 2023-12-31 | −2.64% | +6.35 pp |
| Q3 2023 | 2023-09-30 | −39.64% | −31.93 pp |
| Q2 2023 | 2023-06-30 | −18.65% | −2.89 pp |
| Q1 2023 | 2023-03-31 | −23.47% | −14.67 pp |
| Q4 2022 | 2022-12-31 | −8.98% | −43.48 pp |
| Q3 2022 | 2022-09-30 | −7.71% | +7.11 pp |
| Q2 2022 | 2022-06-30 | −15.76% | −2.95 pp |
| Q1 2022 | 2022-03-31 | −8.80% | +3.83 pp |
| Q4 2021 | 2021-12-31 | 34.50% | +67.84 pp |
| Q3 2021 | 2021-09-30 | −14.82% | −13.04 pp |
| Q2 2021 | 2021-06-30 | −12.80% | −10.93 pp |
| Q1 2021 | 2021-03-31 | −12.62% | −9.82 pp |
| Q4 2020 | 2020-12-31 | −33.35% | −46.48 pp |
| Q3 2020 | 2020-09-30 | −1.77% | −3.78 pp |
| Q2 2020 | 2020-06-30 | −1.87% | −1.80 pp |
| Q1 2020 | 2020-03-31 | −2.80% | −10.29 pp |
| Q4 2019 | 2019-12-31 | 13.14% | −23.26 pp |
| Q3 2019 | 2019-09-30 | 2.01% | +2.66 pp |
| Q2 2019 | 2019-06-30 | −0.07% | +8.02 pp |
| Q1 2019 | 2019-03-31 | 7.49% | +7.97 pp |
| Q4 2018 | 2018-12-31 | 36.40% | +37.39 pp |
| Q3 2018 | 2018-09-30 | −0.65% | +0.35 pp |
| Q2 2018 | 2018-06-30 | −8.09% | −6.61 pp |
| Q1 2018 | 2018-03-31 | −0.49% | −6.44 pp |
| Q4 2017 | 2017-12-31 | −0.99% | −22.62 pp |
| Q3 2017 | 2017-09-30 | −1.00% | −6.86 pp |
| Q2 2017 | 2017-06-30 | −1.48% | +40.73 pp |
| Q1 2017 | 2017-03-31 | 5.95% | +41.00 pp |
| Q4 2016 | 2016-12-31 | 21.63% | +53.64 pp |
| Q3 2016 | 2016-09-30 | 5.86% | +18.97 pp |
| Q2 2016 | 2016-06-30 | −42.21% | −54.59 pp |
| Q1 2016 | 2016-03-31 | −35.06% | −28.79 pp |
| Q4 2015 | 2015-12-31 | −32.02% | −42.33 pp |
| Q3 2015 | 2015-09-30 | −13.11% | −5.61 pp |
| Q2 2015 | 2015-06-30 | 12.37% | +15.64 pp |
| Q1 2015 | 2015-03-31 | −6.27% | +2.05 pp |
| Q4 2014 | 2014-12-31 | 10.31% | +16.53 pp |
| Q3 2014 | 2014-09-30 | −7.50% | −1.37 pp |
| Q2 2014 | 2014-06-30 | −3.26% | +0.10 pp |
| Q1 2014 | 2014-03-31 | −8.31% | −7.44 pp |
| Q4 2013 | 2013-12-31 | −6.23% | — |
| Q3 2013 | 2013-09-30 | −6.12% | — |
| Q2 2013 | 2013-06-30 | −3.36% | — |
| Q1 2013 | 2013-03-31 | −0.87% | — |
| Q2 2011 | 2011-06-30 | −8.13% | +0.95 pp |
| Q1 2011 | 2011-03-31 | −8.47% | — |
| Q4 2010 | 2010-12-31 | −5.61% | — |
| Q3 2010 | 2010-09-30 | −4.83% | — |
| Q2 2010 | 2010-06-30 | −9.08% | — |
Ionis Pharmaceuticals return on equity trends
Over the last five fiscal years, Ionis Pharmaceuticals's return on equity decreased from −40.13% to −70.80%, a change of −30.67 percentage points. The latest reported quarter, Q2 2026, shows −24.62%.
About the metric
What return on equity (ROE) means
Return on equity (ROE) measures how much net income a company generates relative to shareholders’ equity. It can help evaluate how efficiently equity capital is used, but unusually high or negative values may reflect leverage, losses, or a small equity base.
Calculation and source
How return on equity is calculated
TickerStat calculates ROE as SEC-reported net income divided by average stockholders’ equity at the beginning and end of the fiscal period. Periods with missing or non-positive average equity are omitted. Quarterly ROE uses quarterly net income and is not annualized. Fiscal periods can differ from calendar years, so exact period-end dates are included.
Review Ionis Pharmaceuticals source filings ↗