Revenue
2011
2012
2013
2014
2015
2016
2017
2018
2019
2020
2021
2022
2023
2024
2025
| 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | $1.73B | $806.8M | $937.8M | $698.8M | $538.6M | $380.8M | $307.0M | $264.7M | $194.4M | $82.7M | $36.8M | $25.2M | $34.7M | $33.9M | $105.4M |
| Gross profit | $1.68B | $749.4M | $872.3M | $654.1M | N/A | N/A | $294.8M | $252.1M | $189.8M | $82.7M | $36.8M | N/A | N/A | N/A | N/A |
| Gross margin | 97.28% | 92.89% | 93.02% | 93.61% | N/A | N/A | 96.05% | 95.21% | 97.65% | 100.00% | 100.00% | N/A | N/A | N/A | N/A |
| Research & development | $455.2M | $534.5M | $666.6M | $651.5M | $540.7M | $477.6M | $257.5M | $172.0M | $117.5M | $117.6M | $121.8M | $79.8M | $54.9M | $46.1M | $58.7M |
| Operating expenses | $863.7M | $1.11B | $1.38B | $1.15B | $913.0M | $812.5M | $548.1M | $380.4M | $258.7M | $214.8M | $203.9M | $124.7M | $80.1M | $60.8M | $74.8M |
| Operating income | $866.9M | −$302.6M | −$439.5M | −$447.4M | −$374.4M | −$431.8M | −$241.2M | −$115.7M | −$64.3M | −$132.1M | −$167.1M | −$99.4M | −$45.4M | −$26.8M | $30.6M |
| Operating margin | 50.09% | −37.50% | −46.86% | −64.03% | −69.52% | −113.39% | −78.56% | −43.70% | −33.07% | −159.67% | −454.58% | −393.79% | −130.85% | −78.97% | 29.01% |
| EBITDA | $905.8M | −$226.9M | −$202.9M | −$318.6M | −$310.3M | −$388.3M | −$209.0M | −$89.6M | −$46.6M | −$128.8M | −$164.3M | −$97.2M | −$43.0M | −$24.1M | $33.5M |
| EBITDA margin | 52.34% | −28.13% | −21.64% | −45.59% | −57.61% | −101.97% | −68.08% | −33.84% | −23.98% | −155.70% | −446.76% | −384.94% | −123.94% | −71.01% | 31.74% |
| Net income | $682.6M | −$363.3M | −$626.6M | −$559.0M | −$523.9M | −$438.2M | −$251.6M | −$128.1M | −$79.0M | −$142.1M | −$170.4M | −$93.8M | −$51.6M | −$26.2M | $30.9M |
| Net profit margin | 39.44% | −45.03% | −66.81% | −80.00% | −97.27% | −115.07% | −81.95% | −48.38% | −40.64% | −171.83% | −463.60% | −371.37% | −148.65% | −77.28% | 29.32% |
| Basic EPSper basic share | $8.58 | -$4.73 | -$8.37 | -$7.79 | -$7.43 | -$6.64 | -$4.27 | -$2.75 | -$2.02 | -$4.17 | -$5.07 | -$2.97 | -$5.18 | $219.76 | $23.95 |
| Diluted EPSper diluted share | $7.78 | -$4.73 | -$8.37 | -$7.79 | -$7.43 | -$6.64 | -$4.27 | -$2.75 | -$2.02 | -$4.17 | -$5.07 | -$2.97 | -$5.18 | $42.50 | $4.55 |
Reported shareholders
| Holder | % owned |
|---|---|
BlackRock, Inc. | 16.76%13.96M shares |
RTW INVESTMENTS, LP | 9.30%7.75M shares |
Jupiter Topco LLC | 8.68%7.24M shares |
VANGUARD PORTFOLIO MANAGEMENT LLC | 5.91%4.93M shares |
STATE STREET CORP | 5.52%4.6M shares |
WELLINGTON MANAGEMENT GROUP LLP | 4.95%4.13M shares |
VANGUARD CAPITAL MANAGEMENT LLC | 4.49%3.74M shares |
SCHMERTZLER MICHAEL | ≈3.31%2.76M shares |
GEODE CAPITAL MANAGEMENT, LLC | 2.65%2.21M shares |
TORONTO DOMINION BANK | 2.60%2.17M shares |
WESTFIELD CAPITAL MANAGEMENT CO LP | 2.35%1.96M shares |
Hood River Capital Management LLC | 2.09%1.74M shares |
WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 2.07%1.72M shares |
D. E. Shaw & Co., Inc. | 1.86%1.55M shares |
TANG CAPITAL MANAGEMENT LLC | 1.80%1.5M shares |
BANK OF AMERICA CORP /DE/ | 1.74%1.45M shares |
Driehaus Capital Management LLC | 1.73%1.44M shares |
FMR LLC | 1.68%1.4M shares |
Jefferies Financial Group Inc. | 1.63%1.36M shares |
FULLER & THALER ASSET MANAGEMENT, INC. | 1.39%1.16M shares |
Percentages use 83.33M shares of this listed class outstanding on Jun 30, 2026. ≈ compares the latest reported holding with a share total from a different date; it is not a confirmed current stake.
Gray completes the 100% scale. Reported positions may overlap; holders have different reporting dates.
| Transaction | Insider | Type | Shares | Price | Value | Owned after |
|---|---|---|---|---|---|---|
| Sep 17, 2026Form 4 · 10b5-1 | SCHMERTZLER MICHAELDirector | SellCommon Stock · indirect | 376 | $68.45 | $25.7K | 1.30M |
| Sep 17, 2026Form 4 · 10b5-1 | SCHMERTZLER MICHAELDirector | SellCommon Stock · indirect | 9.6K | $67.83 | $652.8K | 1.30M |
| Sep 16, 2026Form 4 · 10b5-1 | SCHMERTZLER MICHAELDirector | SellCommon Stock · indirect | 7.0K | $67.35 | $471.9K | 1.31M |
| Sep 16, 2026Form 4 · 10b5-1 | SCHMERTZLER MICHAELDirector | SellCommon Stock · indirect | 3.0K | $66.58 | $199.3K | 1.31M |
| Sep 10, 2026Form 4 · 10b5-1 | SCHMERTZLER MICHAELDirector | SellCommon Stock · indirect | 10.0K | $67.34 | $673.4K | 1.32M |
PTC Therapeutics ($PTCT) raised its full-year 2026 revenue expectation to $1.29–$1.32 billion and increased product-sales guidance to $960–$990 million from $850–$950 million. Third-quarter 2026 product and royalty revenue reached $357.6 mi ...