Revenue
2009
2010
2011
2012
2013
2015
2016
2017
2018
2019
2020
2021
2022
2023
2024
2025
| 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | $606.4M | $363.7M | $305.2M | $245.4M | $188.5M | $164.4M | $136.5M | $9.8M | $0 | $0 | $0 | N/A | $11.5M | $0 | $4.4M | $6.9M | $10.4M |
| Gross profit | $483.5M | $278.0M | $239.6M | $190.2M | $144.3M | $124.5M | $112.3M | $7.4M | $0 | $0 | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
| Gross margin | 79.73% | 76.43% | 78.52% | 77.53% | 76.57% | 75.75% | 82.26% | 75.36% | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
| Research & development | $771.1M | $598.4M | $571.0M | $397.5M | $272.7M | $181.2M | $131.7M | $145.3M | $109.7M | $122.7M | $74.3M | $56.3M | $44.3M | $29.8M | $28.6M | $4.7M | $9.2M |
| Operating expenses | $1.73B | $1.16B | $949.3M | $647.6M | $519.4M | $389.8M | $347.5M | $314.8M | $188.9M | $173.4M | $117.5M | $87.4M | $66.5M | $42.4M | $66.1M | $15.0M | $19.0M |
| Operating income | −$1.25B | −$878.3M | −$709.6M | −$457.3M | −$375.1M | −$265.2M | −$235.2M | −$307.3M | −$188.9M | −$173.4M | −$117.5M | −$87.4M | −$55.0M | −$42.4M | −$61.7M | −$8.1M | −$8.7M |
| Operating margin | −205.59% | −241.47% | −232.51% | −186.39% | −199.03% | −161.32% | −172.38% | −3,124.94% | N/A | N/A | N/A | N/A | −478.39% | N/A | −1,397.31% | −116.92% | −83.62% |
| EBITDA | −$1.23B | −$867.2M | −$704.1M | −$452.0M | −$366.0M | −$256.1M | −$230.0M | −$303.7M | −$186.0M | −$171.0M | −$115.5M | −$86.3M | −$54.3M | −$41.9M | −$61.4M | −$8.0M | −$8.0M |
| EBITDA margin | −202.88% | −238.44% | −230.70% | −184.23% | −194.20% | −155.79% | −168.57% | −3,088.34% | N/A | N/A | N/A | N/A | −472.48% | N/A | −1,389.54% | −116.14% | −76.81% |
| Net income | −$1.28B | −$913.8M | −$749.6M | −$481.5M | −$434.7M | −$294.1M | −$254.3M | −$324.3M | −$192.6M | −$176.3M | −$118.2M | −$79.2M | −$56.1M | −$41.4M | −$59.7M | −$6.4M | $118.3M |
| Net profit margin | −210.54% | −251.24% | −245.59% | −196.26% | −230.63% | −178.87% | −186.37% | −3,297.17% | N/A | N/A | N/A | N/A | −487.59% | N/A | −1,350.78% | −92.96% | 1,140.94% |
| Basic EPSper basic share | -$6.42 | -$5.57 | -$5.34 | -$3.91 | -$3.88 | -$3.01 | -$3.01 | -$4.22 | -$2.89 | -$2.85 | -$2.02 | -$1.84 | -$1.60 | -$1.56 | -$29.50 | -$4.90 | $93.10 |
| Diluted EPSper diluted share | -$6.42 | -$5.57 | -$5.34 | -$3.91 | -$3.88 | -$3.01 | -$3.01 | -$4.22 | -$2.89 | -$2.85 | -$2.02 | -$1.84 | -$1.60 | -$1.56 | -$29.50 | -$4.90 | $93.00 |
Reported shareholders
| Holder | % owned |
|---|---|
FMR LLC | 7.40%16.14M shares |
BlackRock, Inc. | 7.24%15.81M shares |
JPMORGAN CHASE & CO | 4.78%10.43M shares |
VANGUARD PORTFOLIO MANAGEMENT LLC | 4.77%10.41M shares |
VANGUARD CAPITAL MANAGEMENT LLC | 4.49%9.79M shares |
BAKER BROS. ADVISORS LP | 4.03%8.8M shares |
Capital International Investors | 3.77%8.24M shares |
Darwin Global Management, Ltd. | 2.95%6.43M shares |
AMERIPRISE FINANCIAL INC | 2.83%6.18M shares |
Orbis Allan Gray Ltd | 2.78%6.08M shares |
STATE STREET CORP | 2.77%6.05M shares |
D. E. Shaw & Co., Inc. | 2.69%5.88M shares |
Artisan Partners Limited Partnership | 2.49%5.44M shares |
RTW INVESTMENTS, LP | 2.22%4.84M shares |
GEODE CAPITAL MANAGEMENT, LLC | 1.93%4.22M shares |
PRICE T ROWE ASSOCIATES INC /MD/ | 1.56%3.41M shares |
NORGES BANK | 1.55%3.38M shares |
Jupiter Topco LLC | 1.19%2.61M shares |
UBS Group AG | 1.18%2.58M shares |
CITADEL ADVISORS LLC | 1.17%2.56M shares |
Percentages use 218.28M shares of this listed class outstanding on Jun 30, 2026.
Gray completes the 100% scale. Reported positions may overlap; holders have different reporting dates.
| Transaction | Insider | Type | Shares | Price | Value | Owned after |
|---|---|---|---|---|---|---|
| Sep 9, 2026Form 4 | Brennan David RDirector | SellCommon Stock | 25.0K | $124.00 | $3.10M | 39.2K |
| Aug 17, 2026Form 4 | SHAROKY MELVIN MDDirector | SellCommon Stock · indirect | 5.0K | $127.53 | $637.6K | 0 |
| Aug 10, 2026Form 4 | Adsett RogerChief Operating Officer | SellCommon Stock | 239.8K | $133.27 | $31.96M | 98.7K |
| Aug 6, 2026Form 4 · 10b5-1 | Flammer Martina M.D.Chief Medical Officer | SellCommon Stock | 18.3K | $129.40 | $2.37M | 60.5K |
| Aug 6, 2026Form 4 · 10b5-1 | Flammer Martina M.D.Chief Medical Officer | SellCommon Stock | 8.9K | $127.00 | $1.13M | 78.8K |
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